Thread: Chrysin Reexamined

Chrysin Reexamined
by Anthony Roberts

Despite numerous studies showing that Chrysin does nothing in humans, a number of supplement companies still include it in their formulas, some of which are best-sellers on Bodybuilding.com (MHP’s T-Bomb II comes to mind). To be honest, these formulas are all pretty mediocre and based on outdated research that hasn’t worked out in humans. Or so I thought. A 2011 study (on rats) examined the effects of Chrysin on the little critters’ testosterone, and found that it elevated testosterone as well as other reproductive parameters of the rodents.

Interestingly, although numerous studies (100% of them, actually) show that Chrysin does nothing in human males, the researchers who performed this latest rodent study have concluded that Chrysin can be used for the treatment of male infertility. Even more interesting to note is that the lead researcher on this study, ostensibly one who came to the conclusion that Chrysin can be used to treat infertility, is the same researcher who penned the article showing that it does nothing for testosterone levels in human males.

Beneficial effects of chrysin on the reproductive system of adult male rats.

Ciftci O, Ozdemir I, Aydin M, Beytur A.

Department of Pharmaceutical Toxicology, Faculty of Pharmacy, University of Inonu, Malatya, Turkey  Department of Biochemistry, Faculty of Science and Arts, University of Inonu, Malatya, Turkey  Department of Obstetric and Gynecology, Faculty of Veterinary Medicine, University of Firat, Elazığ, Turkey  Department of Urology, Faculty of Medicine, University of Inonu, Malatya, Turkey.
Abstract

In this study, the beneficial effect of chrysin, a natural flavonoid currently under investigation due to its important biological activities, on reproductive system of rats was investigated. Rats (n = 16) were divided randomly into two equal groups. Rats in control group were given corn oil as carrier. Chrysin was orally administered at the dose of 50 mg kg(-1) per day by gavages, and it was dissolved in corn oil for 60 days. Tissue thiobarbituric acid reactive substances (TBARS) and glutathione (GSH) levels, antioxidant enzyme activity (CAT, SOD and GSH-Px), sperm parameters (motility, concentration and abnormal sperm rate), reproductive organ weight (testes, epididymis, vesicula seminalis, prostate) and serum testosterone levels were determined in the rats. Our results indicated that chrysin significantly increased GSH, CAT, GSH-Px and CuZn-SOD levels, but did not change the formation of TBARS significantly. In addition, sperm motility, sperm concentration and serum testosterone levels significantly increased, whereas abnormal sperm rate significantly decreased with chrysin treatment. In conclusion, it is suggested that treatment with chrysin can positively affect the reproductive system in rats, and it can be used for the treatment of male infertility.

© 2011 Blackwell Verlag GmbH.
PMID: 21486424 [PubMed - as supplied by publisher]

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hmmm I wonder how this will play out... lots of evidence against it, now some for? Should be interesting to see what more studies can show!

|Z|


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