Methyl 1-Test: The True Story

flexster · 12-10-2003, 07:07 AM

Any thoughts on this article:

Methyl 1-Test: The True Story

Q: What is Methyl 1-test? Is it potent? Is it legally sold as a supplement or what? I'm so confused!

A: First, Methyl 1-Test isn’t even proper nomenclature. As for it being potent, Counsell, et al., found that C-17 alkylation of 17B-hydroxy-5a-androst-1-en-3-one (also incorrectly referred to as 1-Testosterone) decreased anabolic and androgenic activity in bioassays. It had about one-fourth the anabolic potency of Testosterone propionate and about half the androgenic activity.

The androgen found in MAG-10, 5a-androst-1-ene (1-Testosterone), was shown to be as androgenic as Testosterone propionate but had twice the anabolic activity. So, in reality, with this so-called methyl-1-Testosterone, you're getting the potential liver toxicity while getting much less benefit.

I think people were excited when they first heard of it as they thought, "Oh, okay, well alkylating 1-Testosterone will solve the problem of oral bioavailability and thus we'll have one kick-ass compound." In reality, adding that methyl group creates not just a methylated version of the androgen, but an entirely different molecule, period!

People need to understand that adding a methyl group or a double bond (or really any number of functional groups and atoms) creates an entirely different androgen. For instance, methandrostenolone (D-bol) only differs from Testosterone by a methyl group at the C-17 and an additional double bond between the C-1 and C-2. But can you honestly say D-bol and Testosterone impart the same effects? Even disregarding bioassays, which have demonstrated substantial differences between the two androgens, it’s still obvious to anyone who’s used them.

Alterations such as these and others in a steroid ring system can easily change the shape or the way in which the steroid molecule interacts with a given receptor, thus we get drastically different effects. Once and for all, will people please understand that a methyl group at the C-17 creates an entirely new androgen and is different from 17 beta-esterifcation as those esters are generally cleaved prior to systemic circulation, whereas the methyl group can’t be cleaved via the esterase enzyme!

As for its legality, I wouldn’t think it would be legal. As far as I’ve always been told, C-17 alkylation isn't something our laws allow in terms of a legal steroid supplement. When I visited the various sites selling this product, it became clear that it likely isn’t legal. Every disclaimer stated that the product was for "research purposes only" and intended for animals, not humans.

They stated in no uncertain terms that if you buy and use the product they aren't liable as they're assuming you’re a licensed researcher using the compound on animals. I’m guessing people think that by claiming this "for research purposes only" they’ll evade the law. Well, unless the people who are buying this product have a DEA license to possess such materials, it's technically illegal. You can claim you’re a "researcher" all you want but without a DEA license, or a very close friend who has one, you don’t have much of a case.

I can’t see this stuff being around for long. Even if it is legal, this is most certainly not something our government agencies would look too highly upon, and in general it makes everyone else in the industry look bad.

The worst part is that it’s actually less potent than the parent steroid molecule! So, let’s see, you get all of these drawbacks and less benefit as compared to the parent molecule. Doesn’t make much sense to me. It’s lowlifes who bring out products like this that give the entire supplement industry a bad name. (15)

**dg806** · 12-10-2003, 07:42 AM

Where did this come from??

**IainDaniel** · 12-10-2003, 07:43 AM

Quote:

Originally posted by flexster
The androgen found in MAG-10, 5a-androst-1-ene (1-Testosterone), was shown to be as androgenic as Testosterone propionate but had twice the anabolic activity. So, in reality, with this so-called methyl-1-Testosterone, you're getting the potential liver toxicity while getting much less benefit.

I don't know alot about PH's but this statement right here would make me think that this is an compaign trying to promote an alternate product "MAG-10"

gopro · 12-10-2003, 08:58 AM

Quote:

Originally posted by dg806
Where did this come from??

From Flex and its crap.

flexster · 12-10-2003, 09:09 AM

Sounded like BS, just thought it was interesting.

topolo · 12-10-2003, 09:17 AM

so gp, you disagree with this?

gopro · 12-10-2003, 11:23 AM

Twisting science to serve an agenda.

Methyl 1-test is undoubtedly the closest thing to illegal anabolic steroids on the market right now. Soon, it will go from being able to be bought over the counter and onto your local black market steroid dealer's list of products.

**dg806** · 12-10-2003, 11:46 AM

Quote:

Originally posted by gopro
From Flex and its crap.

I figured that much, that's why I wanted to know.

**Dale Mabry** · 12-10-2003, 12:18 PM

This is from T-mag by Cy Wilson, I can't believe you guys haven't seen this yet, it is from 2 weeks ago.

**Mudge** · 12-10-2003, 12:37 PM

Quote:

Originally posted by gopro
Methyl 1-test is undoubtedly the closest thing to illegal anabolic steroids on the market right now. Soon, it will go from being able to be bought over the counter and onto your local black market steroid dealer's list of products.

Sounds about right, I have never tried it but everyone is raving about it.

**Mudge** · 12-10-2003, 12:38 PM

Quote:

Originally posted by Dale Mabry
This is from T-mag by Cy Wilson, I can't believe you guys haven't seen this yet, it is from 2 weeks ago.

Uh oh, Cy "Low IQ" Wilson, gotcha.

**dg806** · 12-10-2003, 12:44 PM

I don't read t-mag~

gopro · 12-10-2003, 12:55 PM

Quote:

Originally posted by dg806
I don't read t-mag~

Ooops, meant t-mag. I actually like Testosterone magazine, but this is just a way for Biotest to try and hurt M 1-T sales, especially now that VPX sells it.

Power Rabbit · 12-10-2003, 02:52 PM

Ya i saw that article...From the sheer amount of posts I see praiseing M1t, Im sure that that the guy writein the article is an idiot or a lier. He needs to do the shit before he comments on it.... random chemistry scientifical stuff doesnt impress me...peoples reports on gains impress me.....gopro's, and dale's reports on M1t were informative and gave me info that made sense. I definately respect them alot more then the t-mag guy.

**Dale Mabry** · 12-10-2003, 03:05 PM

He has since rescinded his statements stating that you cannot take a levator ani assay as proof that smoething won't work in real life.

12-10-2003, 07:07 AM	#1
flexster Registered User Join Date: Oct 2003 Posts: 287	Methyl 1-Test: The True Story Any thoughts on this article: Methyl 1-Test: The True Story Q: What is Methyl 1-test? Is it potent? Is it legally sold as a supplement or what? I'm so confused! A: First, Methyl 1-Test isn’t even proper nomenclature. As for it being potent, Counsell, et al., found that C-17 alkylation of 17B-hydroxy-5a-androst-1-en-3-one (also incorrectly referred to as 1-Testosterone) decreased anabolic and androgenic activity in bioassays. It had about one-fourth the anabolic potency of Testosterone propionate and about half the androgenic activity. The androgen found in MAG-10, 5a-androst-1-ene (1-Testosterone), was shown to be as androgenic as Testosterone propionate but had twice the anabolic activity. So, in reality, with this so-called methyl-1-Testosterone, you're getting the potential liver toxicity while getting much less benefit. I think people were excited when they first heard of it as they thought, "Oh, okay, well alkylating 1-Testosterone will solve the problem of oral bioavailability and thus we'll have one kick-ass compound." In reality, adding that methyl group creates not just a methylated version of the androgen, but an entirely different molecule, period! People need to understand that adding a methyl group or a double bond (or really any number of functional groups and atoms) creates an entirely different androgen. For instance, methandrostenolone (D-bol) only differs from Testosterone by a methyl group at the C-17 and an additional double bond between the C-1 and C-2. But can you honestly say D-bol and Testosterone impart the same effects? Even disregarding bioassays, which have demonstrated substantial differences between the two androgens, it’s still obvious to anyone who’s used them. Alterations such as these and others in a steroid ring system can easily change the shape or the way in which the steroid molecule interacts with a given receptor, thus we get drastically different effects. Once and for all, will people please understand that a methyl group at the C-17 creates an entirely new androgen and is different from 17 beta-esterifcation as those esters are generally cleaved prior to systemic circulation, whereas the methyl group can’t be cleaved via the esterase enzyme! As for its legality, I wouldn’t think it would be legal. As far as I’ve always been told, C-17 alkylation isn't something our laws allow in terms of a legal steroid supplement. When I visited the various sites selling this product, it became clear that it likely isn’t legal. Every disclaimer stated that the product was for "research purposes only" and intended for animals, not humans. They stated in no uncertain terms that if you buy and use the product they aren't liable as they're assuming you’re a licensed researcher using the compound on animals. I’m guessing people think that by claiming this "for research purposes only" they’ll evade the law. Well, unless the people who are buying this product have a DEA license to possess such materials, it's technically illegal. You can claim you’re a "researcher" all you want but without a DEA license, or a very close friend who has one, you don’t have much of a case. I can’t see this stuff being around for long. Even if it is legal, this is most certainly not something our government agencies would look too highly upon, and in general it makes everyone else in the industry look bad. The worst part is that it’s actually less potent than the parent steroid molecule! So, let’s see, you get all of these drawbacks and less benefit as compared to the parent molecule. Doesn’t make much sense to me. It’s lowlifes who bring out products like this that give the entire supplement industry a bad name. (15)

12-10-2003, 07:42 AM	#2
dg806 Guardian of The Homeland Super Moderator Join Date: Jan 2002 Location: Charlotte NC Posts: 18,196	Where did this come from?? 1-Andro Rx Pro-hormone

12-10-2003, 11:23 AM	#7
gopro NGA/IFPA Pro Bodybuilder Elite Member Join Date: Jul 2001 Location: GLOBAL! Posts: 10,893	Twisting science to serve an agenda. Methyl 1-test is undoubtedly the closest thing to illegal anabolic steroids on the market right now. Soon, it will go from being able to be bought over the counter and onto your local black market steroid dealer's list of products. All American EFX Sponsored Pro Bodybuilder/Internet Marketing Manager P/RR/S DVD and E-Book now available! P/RR/S DVD http://www.home-gym.com/erbrporepras.html P/RR/S E-BOOK html www.X-traordinaryWorkouts.com Monthly columnist for Muscular Development and Ironman magazines. www.prrstraining.com Time to GROW Without Plateau! Personal Training Gopro is available for online personal training, dietary guidance, and contest prep coaching. Send me a PM or e-mail if interested. Thank you.

12-10-2003, 12:18 PM	#9
Dale Mabry Moderator Moderator Join Date: May 2003 Location: Elsewhere Posts: 14,335 Photos: 10	This is from T-mag by Cy Wilson, I can't believe you guys haven't seen this yet, it is from 2 weeks ago. If sense were common, everyone would have it. 4/2007-Current 75th Ranked most popular image 1 spot behind Prince's bulge...

12-10-2003, 12:44 PM	#12
dg806 Guardian of The Homeland Super Moderator Join Date: Jan 2002 Location: Charlotte NC Posts: 18,196	I don't read t-mag~ 1-Andro Rx Pro-hormone

12-10-2003, 09:09 AM	#5
flexster Registered User Join Date: Oct 2003 Posts: 287	Sounded like BS, just thought it was interesting.

12-10-2003, 02:52 PM	#14
Power Rabbit The Bunny Is Bulking! Elite Member Join Date: Nov 2003 Location: Virginia Posts: 1,027 Photos: 3	Ya i saw that article...From the sheer amount of posts I see praiseing M1t, Im sure that that the guy writein the article is an idiot or a lier. He needs to do the shit before he comments on it.... random chemistry scientifical stuff doesnt impress me...peoples reports on gains impress me.....gopro's, and dale's reports on M1t were informative and gave me info that made sense. I definately respect them alot more then the t-mag guy.

12-10-2003, 03:05 PM	#15
Dale Mabry Moderator Moderator Join Date: May 2003 Location: Elsewhere Posts: 14,335 Photos: 10	He has since rescinded his statements stating that you cannot take a levator ani assay as proof that smoething won't work in real life. If sense were common, everyone would have it. 4/2007-Current 75th Ranked most popular image 1 spot behind Prince's bulge...

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