As efficiently as you can diet. I can lose 1/4" off my waist for the first few days on T3 @ 60mcg daily, coupled with a keto style diet.
Clen is more dangerous IMO, be carefull with it. Alot of people swear off of it after using it only once.
I'm half guessing you are 16 years old, and this is not a supplement, its a thyroid drug/medication.