GH Peptides from IBE

musclepump · 01-22-2005, 03:05 PM

Anyone have any thoughts/info on this new stuff from IBE...

http://www.ibenutrition.com/LABS/peptides.htm

Tha Don · 01-22-2005, 03:29 PM

GH peptides

interesting

redspy · 01-22-2005, 04:27 PM

Interesting stuff. Hopefully there will be be some logs appearing to see how effective this stuff is.

biggmike777 · 01-22-2005, 04:34 PM

GH Peptide do work, unlike most over the counter GH supps. I pulled a study on GHRP-2 and 6.

The effects of GH-releasing peptide-6 (GHRP-6) and GHRP-2 on intracellular adenosine 3',5'-monophosphate (cAMP) levels and GH secretion in ovine and rat somatotrophs
D Wu, C Chen, J Zhang, C Y Bowers(1) and I J Clarke
Prince Henry's Institute of Medical Research, PO Box 5152, Clayton, Victoria 3168, Australia and (1) Department of Medicine, Tulane University Medical Center, New Orleans, Louisiana 70112, USA

(Requests for offprints should be addressed to C Chen)
Abstract

The mechanism of action of GH-releasing peptide-6 (GHRP-6) and GHRP-2 on GH release was investigated in ovine and rat pituitary cells in vitro. In partially purified sheep somatotrophs, GHRP-2 and GH-releasing factor (GRF) increased intracellular cyclic AMP (cAMP) concentrations and caused GH release in a dose- dependent manner; GHRP-6 did not increase cAMP levels. An additive effect of maximal doses of GRF and GHRP-2 was observed in both cAMP and GH levels whereas combined GHRP-6 and GHRP-2 at maximal doses produced an additive effect on GH release only. Pretreatment of the cells with MDL 12,330A, an adenylyl cyclase inhibitor, prevented cAMP accumulation and the subsequent release of GH that was caused by either GHRP-2 or GRF. The cAMP antagonist, Rp-cAMP also blocked GH release in response to GHRP-2 and GRF. The cAMP antagonist did not prevent the effect of GHRP-6 on GH secretion whereas MDL 12,330A partially reduced the effect. An antagonist for the GRF receptor, [Ac- Tyr(1) ,d- rg(2) ]-GRF 1-29, significantly diminished the effect of GHRP-2 and GRF on cAMP accumulation and GH release, but did not affect GH release induced by GHRP-6. Somatostatin prevented cAMP accumulation and GH release responses to GHRP-2, GRF and GHRP-6. Ca(2+) channel blockade did not affect the cAMP increase in response to GHRP-2 or GRF but totally prevented GH release in response to GHRP-2, GRF and GHRP-6. These results indicated that GHRP-2 acts on ovine pituitary somatotrophs to increase cAMP concentration in a manner similar to that of GRF; this occurs even during the blockade of Ca(2+) influx. GHRP-6 caused GH release without an increase in intracellular cAMP levels. GHrelease in response to all three secretagogues was reduced by somatostatin and was dependent upon the influx of extracellular Ca(2+) . The additive effect of GHRP-2 and GRF or GHRP-6 suggested that the three peptides may act on different receptors. In rat pituitary cell cultures, GHRP-6 had no effect on cAMP levels, but potentiated the effect of GRF on cAMP accumulation. The synergistic effect of GRF and GHRP-6 on cAMP accumulation did not occur in sheep somatotrophs. Whereas GHRP-2 caused cAMP accumulation in sheep somatotrophs, it did not do so in rat pituitary cells. These data indicate species differences in the response of pituitary somatotrophs to the GHRPs and this is probably due to different subtypes of GHRP receptor in rat or sheep.

The only problem with the peptides is dosing them properly.
GHRP-6, for reference, produces maximal results at 2mcg/kg Intravenously. Intranasally, GHRP-6 requires a 20mcg/kg dose, and orally it is dosed anywhere from 20-40 mg per dose. The only cost effective way of dosing appears to be intravenously.

musclepump · 01-22-2005, 06:15 PM

Thanks Mike

**Pirate!** · 01-22-2005, 08:44 PM

Looks good on paper, but could be the next myostatin blocker for all anyone knows at this point.

01-22-2005, 03:05 PM	#1
musclepump Celebrity PersonalTrainer Join Date: Nov 2004 Posts: 6,663 Photos: 128	GH Peptides from IBE BODYBUILDING SUPPLEMENTS High Quality Supplements For Bodybuilders and Athletes. www.ironmaglabs.com Anyone have any thoughts/info on this new stuff from IBE... http://www.ibenutrition.com/LABS/peptides.htm
	Let's all join together and SPEAK ENGLISH IN AMERICA.

01-22-2005, 04:27 PM	#3
redspy Member Join Date: May 2004 Posts: 3,040	Interesting stuff. Hopefully there will be be some logs appearing to see how effective this stuff is.
redspy Member Join Date: May 2004 Posts: 3,040

01-22-2005, 06:15 PM	#5
musclepump Celebrity PersonalTrainer Join Date: Nov 2004 Posts: 6,663 Photos: 128	Thanks Mike
	Let's all join together and SPEAK ENGLISH IN AMERICA.

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01-22-2005, 03:29 PM	#2
Tha Don Registered User Join Date: Aug 2003 Location: Nottingham, England Posts: 3,826 Photos: 33	GH peptides interesting

01-22-2005, 04:34 PM	#4
biggmike777 Registered User Join Date: Feb 2004 Posts: 52 Photos: 5	GH Peptide do work, unlike most over the counter GH supps. I pulled a study on GHRP-2 and 6. The effects of GH-releasing peptide-6 (GHRP-6) and GHRP-2 on intracellular adenosine 3',5'-monophosphate (cAMP) levels and GH secretion in ovine and rat somatotrophs D Wu, C Chen, J Zhang, C Y Bowers(1) and I J Clarke Prince Henry's Institute of Medical Research, PO Box 5152, Clayton, Victoria 3168, Australia and (1) Department of Medicine, Tulane University Medical Center, New Orleans, Louisiana 70112, USA (Requests for offprints should be addressed to C Chen) Abstract The mechanism of action of GH-releasing peptide-6 (GHRP-6) and GHRP-2 on GH release was investigated in ovine and rat pituitary cells in vitro. In partially purified sheep somatotrophs, GHRP-2 and GH-releasing factor (GRF) increased intracellular cyclic AMP (cAMP) concentrations and caused GH release in a dose- dependent manner; GHRP-6 did not increase cAMP levels. An additive effect of maximal doses of GRF and GHRP-2 was observed in both cAMP and GH levels whereas combined GHRP-6 and GHRP-2 at maximal doses produced an additive effect on GH release only. Pretreatment of the cells with MDL 12,330A, an adenylyl cyclase inhibitor, prevented cAMP accumulation and the subsequent release of GH that was caused by either GHRP-2 or GRF. The cAMP antagonist, Rp-cAMP also blocked GH release in response to GHRP-2 and GRF. The cAMP antagonist did not prevent the effect of GHRP-6 on GH secretion whereas MDL 12,330A partially reduced the effect. An antagonist for the GRF receptor, [Ac- Tyr(1) ,d- rg(2) ]-GRF 1-29, significantly diminished the effect of GHRP-2 and GRF on cAMP accumulation and GH release, but did not affect GH release induced by GHRP-6. Somatostatin prevented cAMP accumulation and GH release responses to GHRP-2, GRF and GHRP-6. Ca(2+) channel blockade did not affect the cAMP increase in response to GHRP-2 or GRF but totally prevented GH release in response to GHRP-2, GRF and GHRP-6. These results indicated that GHRP-2 acts on ovine pituitary somatotrophs to increase cAMP concentration in a manner similar to that of GRF; this occurs even during the blockade of Ca(2+) influx. GHRP-6 caused GH release without an increase in intracellular cAMP levels. GHrelease in response to all three secretagogues was reduced by somatostatin and was dependent upon the influx of extracellular Ca(2+) . The additive effect of GHRP-2 and GRF or GHRP-6 suggested that the three peptides may act on different receptors. In rat pituitary cell cultures, GHRP-6 had no effect on cAMP levels, but potentiated the effect of GRF on cAMP accumulation. The synergistic effect of GRF and GHRP-6 on cAMP accumulation did not occur in sheep somatotrophs. Whereas GHRP-2 caused cAMP accumulation in sheep somatotrophs, it did not do so in rat pituitary cells. These data indicate species differences in the response of pituitary somatotrophs to the GHRPs and this is probably due to different subtypes of GHRP receptor in rat or sheep. The only problem with the peptides is dosing them properly. GHRP-6, for reference, produces maximal results at 2mcg/kg Intravenously. Intranasally, GHRP-6 requires a 20mcg/kg dose, and orally it is dosed anywhere from 20-40 mg per dose. The only cost effective way of dosing appears to be intravenously.