Thread: Ephedrine 25mgx48/Caffeine 200mgx90/Synephrine 10mgx180 $15?!

Wow....I am all over that.

Is that sarcasm? I cant tell, in any case, thats a sick deal, so is their "never get fat stack", basically a regular price capped sesamin with a $5 180 count CLA, man, they are makin some good deals lately

http://www.bulknutrition.com/?products_id=2190 if I had 2 nickels to rub together, id be gettin me some o dat.

did i miss something? I thought ephadrine was banned in the US?

Price looks good, but what's the real deal on Synephrine?

Founds this:

Synephrine is the "active" compound found in the fruit plant called Citrus Auranbium. It is chemically similar to ephedrine and pseudo-ephedrine based products. In theory, synephrine increases the metabolic rate, augments calorie expenditure, improves energy and speeds up fat loss. It has been shown to reduce appetite while increasing feeling of energy. Synephrine works by stimulating specific adrenal receptors rather than all of them like its cousin, ephedrine. It is said to produce all the positive effects associated with ephedrine while avoiding all of the negative ones.

While synephrine sounds like the perfect solution to your fat loss goals be vary wary of its claims. Many of them are not backed by any scientific proof nor have any long-term studies been done on its effects.

But the real question is does it work? And how does it compare to regular EC stack, or ECA?

Dude, just toss it in with your ECA stack. ANd maybe even buy some Yohimbine HCL, supposed to be a lot better than actual Yohimbe bark, but, who knows.

"Dude," I'm not going to just toss it in with my ECA stack, especially if I don't know what it is. And I have read that Yohimbine HCL does not go well with ECA. I think it may be the aspirin part, as I know people do ECY. Anyone have any real input on Synephrine instead of "just toss it in?" Today is the last day of the sale.

there's synephrine in lipo6, if memory serves, and lipo6 has yohimbine and caffeine in it.....

I take a stack of ephedrine 25mg, 2 lipo-6 caps, and a 325mg tab of apsirin and it works fantastically for me, and sorry if you dont like the "Dude", that just happens to be how I speak when Im online, its not as if this is some sort of essay. Though I couldnt tell you exactly what receptors it stimulates, or crap like that, I can tell you that it certainly does no harm, Ive lost a considerable amount of bodyfat, somewhere in the neighborhood of 10 lbs, while still putting on muscle. Granted, its mostly diet and cardio that does the job, but the supps help you get there faster, and with greater results.

And BTW, dont be a jerk when somebody is trying to help you. :P

Bulk Nutrition article, "Synephrine Science"

"Synephrine is a biogenic amine derived from the Citrus aurantium fruit, which is used for a variety of reasons in Traditional Chinese Medicine. It can be used both to aid in fat loss and as an appetite suppressant and animal models indicate that it may aid in alleviating depression.

The mechanism of action of synephrine is relatively unique among weight loss aids. Synephrine is an agonist of the alpha(1) adrenoreceptor [1-2], which is involved in many physiological processes. This adrenoreceptor plays a variety of roles in adipose tissue, such as modulating intracellular Ca2+ and protein kinase C levels and glycogenolysis and lactate production [3]. Correspondingly, alpha(1) agonists increase lipolysis in a variety of experimental paradigms [3-6], including an in vivo increase in lipolysis in human white adipose tissue [4]. This effect is potentiated by beta receptor stimulation, adenosine antagonism, and elevated cAMP levels [5-7], so ephedrine, caffeine, and forskolin may all be synergistic with synephrine. The appetite suppression caused by some agents is also known to be due to alpha(1) agonism [8], so synephrine can also be expected to aid in a fat loss plan in this regard.

The dosage of synephrine typically used is 10-20 mg daily, although some use as much as 50 mg daily. It is recommended to start with a low dose and work up, and exercise caution when combining synephrine with stimulants. Synephrine should not be taken if one is taking an MAO inhibitor or blood pressure medication."

. Song DK, Suh HW, Jung JS, Wie MB, Son KH, Kim YH. Antidepressant-like effects of p-synephrine in mouse models of immobility tests. Neurosci Lett. 1996 Aug 23;214(2-3):107-10. [abstract]

2. Brown CM, McGrath JC, Midgley JM, Muir AG, O'Brien JW, Thonoor CM, Williams CM, Wilson VG. Activities of octopamine and synephrine stereoisomers on alpha-adrenoceptors. Br J Pharmacol. 1988 Feb;93(2):417-29. [abstract]

3. Flechtner-Mors M, Jenkinson CP, Alt A, Adler G, Ditschuneit HH. In vivo alpha(1)-adrenergic lipolytic activity in subcutaneous adipose tissue of obese subjects. J Pharmacol Exp Ther. 2002 Apr;301(1):229-33. [abstract]

4. Boschmann M, Krupp G, Luft FC, Klaus S, Jordan J. In vivo response to alpha(1)-adrenoreceptor stimulation in human white adipose tissue. Obes Res. 2002 Jun;10(6):555-8. [abstract]

5. Zhao J, Cannon B, Nedergaard J. alpha1-Adrenergic stimulation potentiates the thermogenic action of beta3-adrenoreceptor-generated cAMP in brown fat cells. J Biol Chem. 1997 Dec 26;272(52):32847-56. [Abstract]

6. Schimmel RJ, Elliott ME, Dehmel VC. Interactions between adenosine and alpha 1-adrenergic agonists in regulation of respiration in hamster brown adipocytes. Mol Pharmacol. 1987 Jul;32(1):26-33. [abstract]

7. Raasmaja A, Larsen PR. Alpha 1- and beta-adrenergic agents cause synergistic stimulation of the iodothyronine deiodinase in rat brown adipocytes. Endocrinology. 1989 Nov;125(5):2502-9. [abstract]

8. Cheng JT, Kuo DY. Both alpha1-adrenergic and D(1)-dopaminergic neurotransmissions are involved in phenylpropanolamine-mediated feeding suppression in mice. Neurosci Lett. 2003 Aug 21;347(2):136-8. [abstract]


I just broke the law, lol... "No part of this article may be reproduced in any form without the permission of David Tolson or Mike McCandless."

Telling someone to just take a supplement blindly without any background knowledge on it is not considered help. I didn't mean to come off as rude, I have no problem with you, I just don't appreciate terrible advice.

Ontop of that, you cannot prove that "it certainly does no harm," especially if the supplement is being described as ephedrine's cousin. Also, thanks for the help, a little late AND also from Bulk Nutrition, which not only did I already see, but I don't consider reliable; I asked for the "real deal," not a company's sales pitch.

Again, sorry if I came off as being a jerk earlier. Take care.

lol, sorry, it was like, midnight when I posted that, yeah "just toss it in" was really crappy advice, lol... In any case, I really dont feel any negative effects, im at 60mg a day.

It's cool, to be honest I wasn't completely sober when I had typed my responses. Yesterday was a game day (Iowa v. UNI) and we kicked their asses.. I mean, everyone was pretty sure we would, but after last weekend with Iowa v. Iowa State (a HUGE upset for a HUGE in-state rivalry), who could be sure.

I'm taking an EC stack right now, planning on tossing in the Aspirin for the last two weeks of the 6-week cycle for my cut.. I'm getting great results on this so far but I will look into Synephrine for perhaps my next cut.. just need to do more research and get more info on it, see if it's really worth taking, especially if EC is doing great for me already.

Are you doing 60mg/day in 3 doses with your EC? Or are you just doing EA with Lipo-6 + the Synephrine? I noticed 1 serving is 1 cap, so does that mean you're taking 2 per time? Out of the three supplements included in this stack deal, the Synephrine is the most expensive.. have you done an EC stack without it previously? If so, how did it compare to current cycle?

No problem-o whatsoever, we all have our days! In any case, Lipo-6 comes with 20mg in every serving (2 caps), So I truly have nothing to compare it to, as all my EC's have used lipo-6, first worked great, im about 2 weeks into my 1+1/2 month one. 25mg E+2 Lipo 6 caps(200mg caffeine, 20mg synephrie, dunno how much guggulsterones, 20mg yohimbe)+1 tab 325mg aspirin, 3x a day, split 4.5 hours apart.