Thread: Creatine

I rarely ever post in the suplement forum. But, here is a creatine study that is really recent (mar. 31, 2006)


CREATINE SUPPLEMENTATION AUGMENTS THE INCREASE IN SATELLITE CELL AND MYONUCLEI NUMBER IN HUMAN SKELETAL MUSCLE INDUCED BY STRENGTH TRAINING.

J Physiol. 2006 Mar 31; [Epub ahead of print] Related Articles,
Links, P. Aagaard


The present study investigated the influence of creatine and protein
supplementation on satellite cell frequency and myonuclei number in
human skeletal muscle during 16 wks of heavy-resistance training. In
a double-blinded design thirty-two healthy, male subjects (19-26
years) were assigned to strength training (STR) while receiving a
timed intake of creatine (STR-CRE) (n==9), protein (STR-PRO) (n==8),
placebo (STR-CON) (n==8) or serving as a non-training control group
(CON) (n==7). Supplementation was given daily (STR-CRE : 6-24 g
creatine monohydrate, STR-PRO: 20 g protein, STR-CON: placebo).
Furthermore, timed protein/placebo intake were administered at all
training sessions. Muscle biopsies were obtained at wks 0, 4, 8 (wk 8
not CON) and 16 of resistance training (3 days/wk). Satellite cells
were identified by immunohistochemistry. Muscle mean fibre (MFA) area
was determined after histochemical analysis. All training regimes
were found to increase the proportion of satellite cells, however,
significantly greater enhancements were observed with creatine
supplementation at wk 4 (compared to STR-CON) and at wk 8 (compared
to STR-PRO and STR-CON) (p<0.01-0.05). At wk 16, satellite cell
number was no longer elevated in STR-CRE, while it remained elevated
in STR-PRO and STR-CON.

Furthermore, creatine supplementation resulted in an increased number
of myonuclei per fibre and increases of 14-17% in MFA at wks 4, 8 and
16 (p<0.01). In contrast, STR-PRO showed increase in MFA only in the
later (16 wks, +8%) and STR-CON only in the early (wk 4, +14%) phases
of training, respectively (p<0.05). In STR-CRE a positive
relationship was found between the percentage increases in MFA and
myonuclei from baseline to week 16, respectively (r==0.67, p<0.05). No
changes were observed in the control group (CON). In conclusion, the
present study demonstrate for the first time that creatine
supplementation in combination with strength training amplifies the
training-induced increase in satellite cell number and myonuclei
concentration in human skeletal muscle fibres, thereby allowing an
enhanced muscle fibre growth in response to strength training.

Originally Posted by dontsurfonmytur

makes me feel even better for my first CEE batch i just got

Yummy!