Tribulus effects on T: 2008

WillBrink · 01-24-2008, 07:23 AM

Although this study did find pos effects on T, note the extract was administered intravenously, and I remain skeptical about the effects found in this study, but, it's interesting reading anyway:

Phytomedicine. 2008 Jan;15(1-2):44-54.Links

The hormonal effects of Tribulus terrestris and its role in the management of male erectile dysfunction - an evaluation using primates, rabbit and rat.

Gauthaman K, Ganesan AP.

Department of Obstetrics & Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, 5 Lower Kent Ridge Road, 119074 Singapore.

Hormonal effects of Tribulus terrestris (TT) were evaluated in primates, rabbit and rat to identify its usefulness in the management of erectile dysfunction (ED). TT extract was administered intravenously, as a bolus dose of 7.5, 15 and 30mg/kg, in primates for acute study. Rabbits and normal rats were treated with 2.5, 5 and 10mg/kg of TT extract orally for 8 weeks, for chronic study. In addition, castrated rats were treated either with testosterone cypionate (10mg/kg, subcutaneously; biweekly for 8 weeks) or TT orally (5mg/kg daily for 8 weeks). Blood samples were analyzed for testosterone (T), dihydrotestosterone (DHT) and dehydroepiandrosterone sulphate (DHEAS) levels using radioimmunoassay.

In primates, the increases in T (52%), DHT (31%) and DHEAS (29%) at 7.5mg/kg were statistically significant. In rabbits, both T and DHT were increased compared to control, however, only the increases in DHT (by 30% and 32% at 5 and 10mg/kg) were statistically significant. In castrated rats, increases in T levels by 51% and 25% were observed with T and TT extract respectively that were statistically significant. TT increases some of the sex hormones, possibly due to the presence of protodioscin in the extract. TT may be useful in mild to moderate cases of ED.

**Prince** · 01-24-2008, 07:43 AM

can you provide the entire study or a link?

WillBrink · 01-24-2008, 08:05 AM

Quote:

Originally Posted by Prince

can you provide the entire study or a link?

That one was an abstract on pubmed. You would have to track down the journal listed and see if they ave a web page with free or paid downloads of the full paper.

**nni** · 01-24-2008, 09:27 AM

yeah chuck D was posting this around. something to consider certainly.

WillBrink · 01-24-2008, 11:05 AM

Quote:

Originally Posted by nni

yeah chuck D was posting this around. something to consider certainly.

Much of it really makes no sense, so I am putting no real weight on it personally.

01-24-2008, 07:23 AM	#1
WillBrink Registered User Join Date: Mar 2005 Location: MA Posts: 656	Tribulus effects on T: 2008 Although this study did find pos effects on T, note the extract was administered intravenously, and I remain skeptical about the effects found in this study, but, it's interesting reading anyway: Phytomedicine. 2008 Jan;15(1-2):44-54.Links The hormonal effects of Tribulus terrestris and its role in the management of male erectile dysfunction - an evaluation using primates, rabbit and rat. Gauthaman K, Ganesan AP. Department of Obstetrics & Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, 5 Lower Kent Ridge Road, 119074 Singapore. Hormonal effects of Tribulus terrestris (TT) were evaluated in primates, rabbit and rat to identify its usefulness in the management of erectile dysfunction (ED). TT extract was administered intravenously, as a bolus dose of 7.5, 15 and 30mg/kg, in primates for acute study. Rabbits and normal rats were treated with 2.5, 5 and 10mg/kg of TT extract orally for 8 weeks, for chronic study. In addition, castrated rats were treated either with testosterone cypionate (10mg/kg, subcutaneously; biweekly for 8 weeks) or TT orally (5mg/kg daily for 8 weeks). Blood samples were analyzed for testosterone (T), dihydrotestosterone (DHT) and dehydroepiandrosterone sulphate (DHEAS) levels using radioimmunoassay. In primates, the increases in T (52%), DHT (31%) and DHEAS (29%) at 7.5mg/kg were statistically significant. In rabbits, both T and DHT were increased compared to control, however, only the increases in DHT (by 30% and 32% at 5 and 10mg/kg) were statistically significant. In castrated rats, increases in T levels by 51% and 25% were observed with T and TT extract respectively that were statistically significant. TT increases some of the sex hormones, possibly due to the presence of protodioscin in the extract. TT may be useful in mild to moderate cases of ED.
	Will @ WWW.BRINKZONE.COM WWW.OptimalSWAT.com

01-24-2008, 07:43 AM	#2
Prince the one & only Administrator Join Date: Nov 2000 Location: Colorado Posts: 33,520 Blog Entries: 25 Photos: 313	can you provide the entire study or a link?
	SBMuscle.com - Discount Supplement Superstore AlltheWhey.com - Bulk Protein Powders CEM Products - Research Chemicals & Supplements MusclePharm - Complete Nutritional Arsenal BigBackGrips - If you lift weights you've got to try these grips!

01-24-2008, 09:27 AM	#4
nni Designer Supplements Moderator Join Date: Oct 2006 Posts: 1,227 Blog Entries: 1	yeah chuck D was posting this around. something to consider certainly.
	www.DesignerSupps.com Adrenalean now available.

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