Palumbo is not making any secret of his use of Usnic Acid in his products.
Originally Posted by Robert
Inside all the cells of the body, ATP (adenosine triphosphate) is the fuel source that powers all daily activities. The majority of this ATP is produced when fats are oxidized (burnt up) inside the mitochondria (power station) of the muscle cell.
Usnic acid is what’s known in the field of biochemistry as an uncoupling agent. Derived from a simple plant lichen, Usnic acid “uncouples” or disconnects the ATP-producing machinery in the cell and “releases” all the potential energy that was supposed to be used to produce ATP.
Due to the energy and ATP loss (which is dissipated as heat), the muscle cells must dig into stored body fat and oxidize additional fats to ensure that optimal energy levels are maintained within the cells.
The following analogy should help explain how Usnic acid exerts its energy-wasting effect in the human body. Imagine someone putting a hole in the gas tank of your automobile. The car would still perform at maximal capacity however, it would require a significant amount of additional fuel to travel the same distance it had before the punctured tank. Individuals who consume 30-60mg of Usnic acid per day usually notice a slight increase in body temperature. This phenomenon is due to the fact that lost energy escapes from the body as heat. Remember, warmth is a good indicator that the Usnic acid is effectively wasting energy and thus burning fat. From Species Nutrition
Likewise, Usnic acid creates temporary “holes” in the mitochondrial membranes which then result in the loss of valuable “fuel” (ATP) from the “tank” (muscle cell). To combat this energy loss, additional fatty acids must be oxidized to ensure optimal performance levels.
Even more exciting is that fact that Usnic acid “wastes” calories without elevating blood pressure, without raising heart rate, and without causing any central nervous system stimulation. An individual can, literally, swallow a dose of Usnic acid, fall asleep, and start burning fat even while unconscious.
"Based on usnic acid doses in case reports of 450 mg to >1 g day−1," according to Metabolism and related human risk factors for hepatic damage by usnic acid containing nutritional supplements; Xenobiotica - 38(3):Pages 264-280 - Informa Healthcare "these in vitro data indicate that usnic acid has significant potential to interact with other medications. Individual characteristics such as CYP1A induction status, co-administration of CYP1A2 inhibitors, UGT1A1 polymorphisms, and related hyperbilirubinaemias, or co-administration of low therapeutic index CYP2C substrates could work alone or in consort with other idiosyncrasy risk factors to increase the risk of adverse events and/or hepatotoxicity. Thus, usnic acid in nutritional supplements might be involved as both victim and/or perpetrator in clinically significant drug–drug interactions."
However Palumbo's Lipolyze contains just 12 mg per capsule. The literature recommends 3 capsules per day with meals for 36 mg per day. That's a far cry from the 450 mg per day noted above.
One aspirin offers pain relief while an entire bottle is potentially fatal. Is that at all analogous to usnic acid?
While I'm no scientist, it seems that Anthony Roberts is more interested in sensationalistic mudslinging than responsible reporting in this instance.