This could depend on what compounds a person was wanting to use. For example if you are going to do something basic like test E or cyp then monday and thurs would work just fine. Pick a time for this morning or evening but keep in mind that we have more natural test in the a.m. But then if a person was going to do prop only then timing comes into play a lot more. I have known people who time things down to a particular hour on each particular day as to their pin schedule. They are extremely into half lifes and want to keep levels real steady. For most of us that really wouldnt be so important. Then theres HRT guys who do a low dose and only pin once a week on the same day. It's when you go into cycle doses that pinning twice per week is more critical. So the answer may be what are you planning to run and how important it is that you keep levels steady.