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E-CONTROL Rx™ - Anti-Estrogen

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  1. #1
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    E-CONTROL Rx™ - Anti-Estrogen

    COMING VERY SOON!


    1,4,6 Androstatriene-dione (ATD)

    Characteristics

    ATD is a steroidal aromatase inhibitor, known as a suicidal inhibitor because it permanently binds to the aromatase enzyme.

    ATD is used for its aromatase inhibiting and testosterone boosting effect. Its effectiveness at lowering estrogen appears to be stronger than 6-oxo. It converts to 1,4,6-testosterone, which would also be expected to cause falsely high readings for a testosterone analysis.

    The 1,4,6-testosterone metabolite of ATD can also bind to the androgen receptor (AR) and induce androgenic (or possibly anti-androgenic) effects similar to what is seen from 6-oxo. This would be expected since 1,4,6-testosterone has about one third the binding affinity for the AR, therefore it may interefere with the anabolic or androgenic action of hormones which bind the androgen receptor.

    ATD would also be expected to interfere with production of natural testosterone by acting upon the hypothalamus pituitary testicular axis (HPTA), therefore this compound should not be used during post cycle therapy (PCT), however it could successfully be used during a cycle to help keep estrogen in control. Anecdotal reports and animal studies have also shown ATD inhibits libido and general sexual potency.

    References

    Effect of an inhibitor of aromatization, 1,4,6 androstatriene-3,17-dione (ATD) on LH release and steroid binding in hypothalamus of adult female rats.

    Exp Brain Res. 1986;64(3):407-10.
    Slama A, Gogan F, Sarrieau A, Vial M, Rostene W, Kordon C.

    Effects of ATD on male sexual behavior and androgen receptor binding: a reexamination of the aromatization hypothesis.
    ME Kaplan and MY McGinnis
    Horm Behav, Mar 1989; 23(1): 10-26.

    Anabolic Pharmacology
    Seth Roberts (2009)

    By Jason Rowland


    Chemical Name(s):

    Androsta-1,4,6-triene-3,17-dione
    1,4,6-androstatriene-3,17-dione

    Chemical Formula: C19H22O2
    Molecular Weight: 282
    CAS: NA
    Q Qatio: NA
    Anabolic #: NA
    Androgenic #: NA
    Oral Bioavailability: Estimated at 4%
    AR Binding Affinity: NA
    SHBG Binding Affinity: NA
    Half Life: 2 days
    Legal Status (US): Not listed as a controlled substance
    Average Dose: 25-100mg/day
    Average Cycle Length: 4-8 weeks

  2. #2
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    ive used it on cycle with decent results. Its cheap and effective, reduced nip issues and dropped water.

    i know it binds to the AR pretty strong according to the write ups.

    IYO, do you feel it would work better with gears that do not have a high affinity for AR binding?

    From my personal experiences, Less is more. 25 mgs sufficed. anything above 50 mgs and say bye to your sex drive.

    Also, i would not use this with Non-aromatizing gears.

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    Quote Originally Posted by Mr. Fantastico View Post
    ive used it on cycle with decent results. Its cheap and effective, reduced nip issues and dropped water.

    i know it binds to the AR pretty strong according to the write ups.

    IYO, do you feel it would work better with gears that do not have a high affinity for AR binding?

    From my personal experiences, Less is more. 25 mgs sufficed. anything above 50 mgs and say bye to your sex drive.

    Also, i would not use this with Non-aromatizing gears.
    There is a ton of misinformation on the web regarding AI's. They do not suppress E2 in men as much as women so I think getting labs is the best way to dial in the dose. Also if you are using testosterone the AI will be even weaker.

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