Anadrol~oxymetholone

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    Anadrol~oxymetholone

    Anadrol

    (oxymetholone)

    By Anthony Roberts

    Anadrol 50 (commonly called by athletes "A50" or "A-bombs") was initially developed as a compound to help people with anemia, and has since been used very successfully to aid people who are suffering from many other diseases where weight loss is a concern. Thus, it is clearly an effective agent for promoting weight gain, increasing appetite, gaining strength, and increasing Red Blood Cell count. And, as with most Anabolic/Androgenic Steroids (AAS), it has it´s downsides as well. Anadrol will inhibit your body´s natural production of hormones (testosterone, etc& ), will negatively affect your blood lipid profile, can cause water retention, is notorious for causing headaches, and is also highly liver toxic (in fact, it has the worst reputation for hepatoxicity out of all steroids). Paradoxically, although one the benefits touted by it´s original manufacturer (Syntex) is that it can be used to stimulate weight gain through increasing appetite, taking too much may actually inhibit your appetite!

    Anadrol Effects on Body

    I think, in order to gain a complete understanding of the Anadrol effects on body, we need to take a look at its advantages contrasted with its disadvantages. Anadrol is a DHT-derived compound, and is 17-Alpha-Alkylated steroid, meaning that it has been altered at the 17th carbon position to survive oral ingestion. Most oral steroids are 17aa, and this helps them make it through your liver in a useful form. Sounds great, right? Lets 17alpha-alkylate everything! Well as you can imagine, there´s a down side.

    Anadrol Side Effects

    This 17aa alteration, which makes it possible for Anadrol to survive its first pass through your liver, also makes it very taxing on your liver. How taxing is A50 and how much weight can you gain from its use? Well, there was a 30 week study done on A50 and, as you can expect, a reasonable amount of side effects were noted. The fact that A50 causes some side effects has really never been in debate. But how effective was the drug? Well, first it should be mentioned that this study was done on people with AIDS related wasting, and they actually gained weight (8+kg) while the control group lost weight, and had increased mortality rates. (1). I suppose, if you´re in a study because you have a wasting disease which is also a terminal illness, you don´t want to end up in the control group& .Anyway, weight gain in this study peaked at 19-20 weeks, though, so the last 10 weeks weren´t very productive in this respect. Clearly, you wouldn´t want to run Anadrol for 20 weeks, given its toxicity, but after that, any effect in terms of weight and strength gains would be negligible. So, with regards to sides from Anadrol, and the sheer fact that this study lasted so long (30 weeks), it should be apparent that they can be kept under control and the drug can be used safely. People are commonly told to limit their intake of A50 to 4 weeks or less& I´m a bit less conservative and think you can easily run A50 for 6 weeks or more.

    From personal experience, however, I can tell you that gains from Anadrol are quite dramatic for the first 3 weeks, and then quickly level off. Unfortunately, I find that the side effects experienced from Anadrol (which include a headache, bloating, elevated blood pressure, and a general "unwell" feeling for me) remain for the entire duration of use& .but I find, as usual, side effects for this drug are pretty much half legend and half truth. Since Anadrol is derived from DHT, it can´t actually convert to estrogen (via the aromatase enzyme), and it´s not a progestin or a compound with progestenic activity so the estrogenic side effects produced by it are of a very mysterious nature. It has been speculated that perhaps it can stimulate the estrogen receptor without actually being converted to estrogen& that´s about as plausible an explanation as I´ve heard& However, things really get strange, when Oxymetholone has been used in studies to alter the female reproductive/menstrual cycle; in those cases, it has lowered plasma progesterone levels! (7)One would expect that an AI (aromatase inhibitor) wouldn´t be of much use with this drug, but many have found that Letrozole (which has, in some cases been shown to reduce estrogen in the body to an undetectable amount)(6) can greatly reduce or even eliminate many of the more noticeable side effects of Anadrol, such as the bloating.

    As I´ve stated, however, the sides from this drug are certainly no joke, but are easily preventable, and controllable. One study even showed very few sides for subjects using up to 100mgs of Oxymetholone (2). In the original UnderGround Steroid HandBook, Dan Duchaine states that he used it at doses up to 150mgs/day. Clearly, Anadrol´s hepatoxicity has been a bit exaggerated, in some circles. Be that as it may, my suggestion is still to limit Anadrol´s use to 8 weeks, at a maximum even if just to err on the side of caution. Of course, I have personally run this drug for much longer..

    How should we use Anadrol? I´d probably be willing to include Anadrol in a cycle including injectable steroids, but not other 17aa compounds. I´d make any 6-week-run of this compound begin at the start of a cycle, as a form of "jumpstart" towards seeing gains quickly. The quick gains you will get from Anadrol (up to a pound per day for the first 2 weeks are not uncommon in Steroid.com members) are also just as quick to disappear upon cessation of use& .unless you are simply using it as a kickstarter, while waiting for your other compounds to kick-in. I´ll go out on a limb here and say that utilizing Anadrol as a "Jumpstart" is the most popular use of this drug for athletes and bodybuilders today. I´ll also say that this drug is immensely popular with strength athletes who don´t have to worry about weight classes (Field athletes and strongmen), and with powerlifters in the heavier weight brackets. It´s also important to note that in one study by Schroder et. Al (2) anadrol showed that it has the ability to lower serum SHBG (Sex Hormone Binding Globulin& which binds to your free test and makes it no longer useful for anabolism, among other things) concentrations by 54.9 ± 25.8 and 45 ± 16.2 nmol/l in the 50- and 100-mg treatment groups. This means there will be more free test circulating around your body when you take this drug& clearly, this would produce some synergy when stacked with other steroids. Given the large amounts of weight and strength which can be gained in a relatively short time span on this drug, I´m sure this comes as no surprise to many.

    Another important and often understated characteristic of this compound is that Oxymetholone doesn´t bind well to the androgen receptor (Relative Binding Affinity = too low to be determined) (3) which is the lowest I´ve ever read about. Basically, what this tells me is that there are a lot of non-receptor mediated effects from this steroid, making it a very potent addition to ANY BULKING stack, because it won´t be competing for the receptor sites with the other steroids you´re using. It´s also, as you may have guessed a very poor choice for a cutting stack.

    ANADROL CYCLES

    What is an Anadrol Cycle? How much should you use? Well, this is actually one of the most interesting facts about Anadrol. You see, most steroids produce what we call a "dose respondent curve" which is a fancy way of saying "the more you use, the more you gain."

    Anadrol is one of the few steroids where the dose respondent curve flattens out very quickly. When you take 50mgs of Anadrol, you´ll make some very good gains. When you take 100mgs of Anadrol, you´ll make even more gains. However, it has been found that 100mgs/day is as effective for weight gain as 150mgs/day but produces less side effects and was less toxic (4). I feel that the jump from 50mgs to 100mgs constitutes an acceptable rise in benefit vs. cost, but this is not the case as dosages get over 100mgs. Now, lets see how 50mgs and 100mgs of Oxymetholone actually effect strength, when compared with each other:

    Relative (%) changes in strength are shown for the groups receiving placebo (filled bars), 50 mg/day oxymetholone (open bars), and 100 mg/day oxymetholone (gray bars). Nos. above bars represent relative change (%) from baseline to week 12 for the 1-repetition maximum tests of strength. Error bars represent ± 1 SE from the mean. * Significant difference from placebo, P < 0.05; significant difference from placebo by Wilcoxon test, P < 0.02. See text for additional statistical analyses.

    As you can see, in this study, doubling the dose of Anadrol nearly doubled the strength gains of the test subjects. Now, when we look at changes in body composition from Oxymetholone (chart below) we can see that although the guys taking the 100mgs (vs. the 50mgs group) had more fat lost and more Lean Body Mass gained, it wasn´t as dramatic as the differences in strength gains between the two groups:

    Changes in body composition are shown for the groups receiving placebo (filled bars), 50 mg of oxymetholone per day (open bars), and 100 mg per day (gray bars). Numbers above the bars represent the mean absolute changes and the error bars are ± 1 SE. For total lean body mass (LBM) and total fat, differences among the 3 groups were significant (P < 0.0001, one-way ANOVA). * Significant differences from placebo, P 0.001.

    Although I am usually not inclined to posit speculations on why a particular drug does or doesn´t do something, in this case I will. I´m guessing that the higher doses of Anadrol cause enough appetite suppression (at least anecdotally) to make eating rather difficult. It can also increase insulin resistance and glucose intolerance (5). This has the effect of making macronutrient absorption more inefficient, and could also be a factor in reducing gains when the dosage goes over 100mgs/day. Unfortunately, Anadrol also has a reasonably profound effect on your body´s natural hormonal system, on par with most other oral steroids, but not as bad as most injectables, and it´s certainly not as harsh on your lipid profile as many anabolics are

    Anadrol Body Building

    (2). As an interesting side note, some of the medical literature on this compound suggests a dose of 1-5mgs per kg of bodyweight. I´ll pause a second here for you to figure out how absurdly high of a dose that would translate to for the average bodybuilder!

    To Buy Anadrol Liquiad Anadrol and others

    This steroid is very available on the black market in the form of capsules, tablets (some are even 75mgs!), liquid, and even paper. Prices will vary, and be indicative of many different factors including the form you buy this compound in (paper will usually be the most expensive, and liquid the least), and where you live. In any case, you shouldn´t be paying more than $2.50-3.00 per 50mgs.

    What is Anadrol?

    (Oxymetholone)
    [17 beta-hydroxy-2-hydroxymethylene-17 alpha-methyl-5 alpha-androstan-3-one]
    Molecular Weight: 332.482
    Molecular Formula: C 21 H 32 O 3
    Melting Point: 178-180C
    Manufacturer: Syntex (Originally)
    Release Date: 1960
    Effective Dose: 100mgs (optimal)
    Active Life: <16hours
    Detection Time: up to 8 weeks
    Androgenic: Anabolic Ratio: 45:320


    References:

    Charts from reference 2:
    Am J Physiol Endocrinol Metab 284: E120-E128, 2003. First published September 24, 2002; doi:10.1152/ajpendo.00363.2002 0193-1849/03

    1. Br J Nutr. 1996 Jan;75(1):129-38.
    2. Schroeder et al. Am J Physiol Endocrinol Metab 284:E 120-28
    3. Endocrinology. 1984 Jun;114(6):2100-6.
    4. HIV Clin Trials. 2003 May-Jun;4(3):150-63.
    5. J Clin Endocrinol Metab. 1981 Nov;53(5):905-8
    6. Epilepsy Behav. 2004 Apr;5(2):260-3
    7. Am J Obstet Gynecol. 1973 Sep 1;117(1):121-5.

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    this is a great study. phase III randomized double blind placebo control. It shows anadrol works great for adding mass in hiv patients, but 100 mg is just as good as 150 mg ed. Plus, they do liver panels out to 16 weeks. 150 mg is worse on the liver than 100. About 25-28% of people show 5x normal liver enzyme values at 16 weeks. Liver issues start creeping in at 12 weeks.

    Again, this is another clear indication that more is not better~Dr Pangloss

    AIDS. 2003 Mar 28;17(5):699-710. Links

    Double-blind, randomized, placebo-controlled phase III trial of oxymetholone for the treatment of HIV wasting.

    Hengge UR, Stocks K, Wiehler H, Faulkner S, Esser S, Lorenz C, Jentzen W, Hengge D, Goos M, Dudley RE, Ringham G.
    STD-Unit, Department of Dermatology and Venerology, University of Essen, Germany. ulrich.hengge@uni-duesseldorf.de

    BACKGROUND: Despite highly active antiretroviral therapy (HAART), chronic involuntary weight loss still remains a serious problem in the care of HIV patients. Various alterations in energy metabolism and endocrine regulation have been found to cause loss of lean body mass (LBM) and body cell mass (BCM). Previous studies in HIV-positive men undergoing androgen replacement therapy or treatment with recombinant growth hormone (rGH) have shown partial restoration of LBM, but these treatments have largely been ineffective in eugonadal individuals.

    STUDY DESIGN: Double-blind, randomized, placebo-controlled trial of 89 HIV-positive women and men with wasting assigned to the anabolic steroid oxymetholone [50 mg twice (BID) or three times daily (TID)] or placebo for 16 weeks followed by open-label treatment.

    STUDY ENDPOINTS: Body weight, bioimpedance measurements, quality of life parameters and appetite. RESULTS: Oxymetholone led to a significant weight gain of 3.0 +/- 0.5 and 3.5 +/- 0.7 kg in the TID and BID groups, respectively (P < 0.05 for each treatment versus placebo), whereas individuals in the placebo group gained an average of 1.0 +/- 0.7 kg. Body cell mass increased in the oxymetholone BID group (3.8 +/- 0.4 kg; P < 0.0001) and in the oxymetholone TID group (2.1 +/- 0.6 kg; P < 0.005), corresponding to 12.4 and 7.4% of baseline BCM, respectively. Significant improvements were noted in appetite and food intake, increased well-being and reduced weakness by self-examination. The most important adverse event was liver-associated toxicity. Overall, 35% of patients in the TID, 27% of patients in the BID oxymetholone group and no patients in the placebo group had a greater than five times baseline increase for alanine aminotransferase during the double-blind phase of the study.

    CONCLUSIONS: Oxymetholone can be considered an effective anabolic steroid in eugonadal male and female patients with AIDS-associated wasting. The BID (100 mg/day) regimen appeared to be equally effective as the TID (150 mg/day) regimen in terms of weight gain, LBM and BCM and was associated with less, but still significant liver toxicity.

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    RANDOMIZED PHASE III TRIAL OF OXYMETHOLONE FOR THE TREATMENT OF HIV WASTING AND LIPODYSTROPHY

    Antiviral Therapy 2001; 6(Suppl. 4):49 (abstract no. 70)

    UR Hengge1, K Stocks1, S Unger1, S Faulkner2, M Goos1 and R Dudley2
    1 STD Unit, Dept. of Dermatology, University of Essen, Germany; and 2 Unimed Pharmaceuticals Inc., Deerfield, III., USA

    Although highly active antiretroviral therapy has greatly impacted treatment of HIV infection, lipodystrophy and HIV wasting still represent unresolved problems in HIV therapy and patient care. Oxymetholone, a testosterone derivative, has been shown to promote weight gain in AIDS-associated wasting. We analysed the effects of oxymetholone (50mg twice and three times daily) in a randomized (1:1:1), double-blind, placebo-controlled Phase III study with 92 subjects (all on antiretroviral therapy) experiencing unintended weight loss >10% of ideal weight according to Broca with special emphasis on body composition measurements. Eighty patients (69 men, 11 women; mean age: 38.8 years) completed the 16-week double-blind study phase. Mean weight gain was +3.7±3.5 and +3.1±2.7 kg in the oxymetholone groups (twice daily; n=25 versus three times daily; n=27) as opposed to +0.97±3.4 kg in the placebo group (P<0.0005). Importantly, statistically significant increases versus placebo were observed in body cell mass (30.6 before versus 32.5 after therapy), lean body mass (56.3 before versus 59.0 after therapy in the twice daily group) and body mass index (21.4 before versus 22.1 after therapy) exclusively in oxymetholone treated patients. The extracellular mass to body cell mass ratio, an indicator of body composition, significantly improved from 0.87 to 0.80 (P<0.0001).Total body fat was unchanged by oxymetholone treatment. Adverse events were mainly hepatic occurring in 14% of oxymetholone-treated patients with significant elevations of AST, ALT and GGT; two patients (7.4%) in the twice daily arm experienced grade 3 and 4 liver toxicity compared with six (21.4%) in the three times daily arm. Oxymetholone was found to have true anabolic effects in a double-blind, placebo-controlled Phase III trial. The twice daily (100 mg/day) regimen appeared equally effective to three times daily (150 mg/day) dosing while displaying reduced liver toxicity. Due to its favorable protein anabolism, it may be recommended for therapy of wasting and lipodystrophy in HIV-infected subjects.


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    OXYMETHOLONE PROMOTES SIGNIFICANT WEIGHT GAIN IN PATIENTS WITH ADVANCED HIV-1 INFECTION.

    Conf Retroviruses Opportunistic Infect 1996 Jan 28-Feb 1; 3rd:126 (abstract no. 394)

    Hengge UR, Baumann M, Maleba R, Brockmeyer N, Goos M
    Univ. of Essen, FRG.

    The effect of the testosterone derivative oxymetholone as monotherapy or in combination with the H1-receptor antagonist ketotifen, which has recently been shown to block tumor necrosis factor α (TNFα), on weight gain and performance status in HIV patients with chronic cachexia was evaluated in a 30-week prospective pilot study. Thirty patients were randomly assigned to either oxymetholone (n=l4) or oxymetholone plus ketotifen (n=16). Patients receiving treatment were compared to a group of 30 untreated matched controls. Body weight, the Karnofsky index and several quality of life parameters were measured to evaluate response to therapy. The average weight gain at peak was 8.2±6.2 kg (+14.5% relative to body weight at study entry) in the oxymetholone group (p < 0.001), and 6.1±4.6 kg (+10.9%) in the combination group (p < 0.005), compared to an average weight loss of 1.8±0.7 kg in the untreated controls. The onset of weight gain was observed after 3-4 weeks, peak weight was reached after 19.6 weeks in the monotherapy and 20.8 weeks in the combination group. The Karnofsky index improved equally in both groups from 56% before to 67% after 20 weeks of treatment (p < 0.05). The quality of life parameters (activities of daily life, and appetite/nutrition) improved in 68% (p < 0.05) and 91% (p < 0.01), respectively. Oxymetholone was safe and promoted weight gain in cachectic patients with advanced HIV-1 infection. The addition of ketotifen did not further support weight gain. These results suggest a randomized, double-blind, placebo-controlled multicenter trial.


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    Oxymetholone for the treatment of HIV-wasting: a double-blind, randomized, placebo-controlled phase III trial in eugonadal men and women.

    Hengge UR, Stocks K, Faulkner S, Wiehler H, Lorenz C, Jentzen W, Hengge D, Ringham G.
    Department of Dermatology, University of Düsseldorf, Düsseldorf, Germany. ulrich.hengge@uni-duesseldorf.de
    Abstract

    BACKGROUND: Despite highly active antiretroviral therapy (HAART), chronic involuntary weight loss still remains a serious problem in the care of HIV patients due to various alterations in energy metabolism and endocrine regulation. Previous studies in HIV-positive men undergoing androgen replacement therapy or treatment with recombinant growth hormone (rGH) have shown partial restoration of lean body mass (LBM), but these treatments have largely not been sufficiently studied in eugonadal individuals.
    METHOD: A double-blind, randomized, placebo-controlled trial of 89 HIV-positive eugonadal women and men with wasting assigned to the anabolic steroid oxymetholone (50 mg bid or tid) or placebo for 16 weeks was performed. Body weight, bioimpedance measurements, quality of life parameters, and appetite were analyzed.

    RESULTS
    : Oxymetholone led to a significant weight gain of 3.0 +/- 0.5 and 3.5 +/- 0.7 kg in the tid and bid groups, respectively (p <.05 for each treatment versus placebo), while individuals in the placebo group gained an average of 1.0 +/- 0.7 kg. Body cell mass (BCM) increased in the oxymetholone bid group (3.8 +/- 0.4 kg; p <.0001) and in the oxymetholone tid group (2.1 +/- 0.6 kg; p <.005). Significant improvements were noted in appetite and food intake, increased wellbeing, and reduced weakness by self-examination. The most important adverse event was liver-associated toxicity. Overall, 43% of patients in the tid group, 25% of patients in the bid oxymetholone group, and 8% in the placebo group had a greater than 5 times baseline increase for ALT, AST, or gamma GT, while other adverse events were not increased over placebo.

    CONCLUSION: Oxymetholone can be considered an effective anabolic steroid in eugonadal male and female patients with AIDS-associated wasting. The bid (100 mg/day) regimen appeared to be equally effective to the tid (150 mg/day) regimen in terms of weight gain, LBM, and BCM and was associated with less liver toxicity.


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    Clin Ther. 2001 Jun;23(6):789-801; discussion 771.
    Review of oxymetholone: a 17alpha-alkylated anabolic-androgenic steroid.

    Pavlatos AM, Fultz O, Monberg MJ, Vootkur A, Pharmd.
    Source

    Northside Family Medicine, Chicago, Illinois 60659-4120, USA.

    Abstract

    BACKGROUND:

    Oxymetholone (17beta-hydroxy-2-[hydroxymethylene]-17-methyl-5alpha-androstan-3-one) is a 17alpha-alkylated anabolic-androgenic steroid and a synthetic derivative of testosterone. It has been approved by the US Food and Drug Administration for the treatment of anemias caused by deficient red cell production.
    OBJECTIVES:

    This review summarizes the pharmacokinetics, current and future clinical applications, and adverse effects of oxymetholone. Relevant studies were identified using a search of MEDLINE through March 2001, supplemented by conference abstracts and presentations.
    RESULTS:

    Because of its anabolic properties, oxymetholone has been studied for the treatment of HIV-associated wasting, antithrombin III deficiency, pediatric growth impairment, and damaged myocardium, with varying degrees of success. Hepatotoxicity is a major adverse effect associated with the use of oxymetholone, with cholestatic jaundice the most important hepatic side effect. Less common hepatic side effects associated with the use of anabolic-androgenic steroids include peliosis hepatis and formation of hepatic tumors. All anabolic-androgenic steroids can cause androgenic side effects, including acne, hirsutism, hair loss, clitoral/phallic enlargement, vocal changes, erectile tissue stimulation, gynecomastia, amenorrhea, and changes in libido and sexual potency.
    CONCLUSIONS:

    As is the case with many anabolic-androgenic steroids, few pharmacokinetic and tolerability studies were performed beforeoxymetholone's approval in the 1960s. It has proved, however, to be an appropriate treatment choice for selected patients with anemia, if carefully monitored.


    PMID: 11440282 [PubMed - indexed for MEDLINE]

    http://www.afboard.com/library/Revie...ymetholone.pdf


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    Great studies

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    Clin J Am Soc Nephrol. 2013 Feb;8(2):271-9. doi: 10.2215/CJN.00380112. Epub 2012 Nov 2.
    Effect of oral anabolic steroid on muscle strength and muscle growth in hemodialysis patients.

    Supasyndh O, Satirapoj B, Aramwit P, Viroonudomphol D, Chaiprasert A, Thanachatwej V, Vanichakarn S, Kopple JD.
    Source

    Division of Nephrology, Phramongkutklao Hospital and College of Medicine, Bangkok, Thailand. ouppatham@hotmail.com

    Abstract

    BACKGROUND AND OBJECTIVES:

    Sarcopenia is common in hemodialysis patients. This study examined whether the anabolic steroid oxymetholone improves muscle mass and handgrip strength in hemodialysis patients and possible mechanisms that might engender such changes.
    DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS:

    Forty-three eligible hemodialysis patients were randomly assigned to ingest oxymetholone or placebo for 24 weeks. Body composition, handgrip strength, and quality of life were measured during the study. Muscle biopsies were performed and analyzed for mRNA levels for myostatin, IGF-I, IGF binding proteins, and myosin heavy chains and protein expression. Muscle fiber types and diameter were assessed by reduced nicotinamide-adenine dinucleotide staining.
    RESULTS:

    There was a significantly greater increase in fat-free mass and handgrip strength and decrease in fat mass in the oxymetholone compared with the placebo group. Moreover, compared with baseline values, patients given oxymetholone exhibited an increase in fat-free mass, handgrip strength, physical functioning scores, and type I muscle fiber cross-sectional area and a decrease in fat mass, whereas patients receiving placebo did not undergo changes. There was a significantly greater increase in muscle mRNA levels for myosin heavy chain 2?, IGF-I, and IGF-II receptor with oxymetholone treatment than placebo. Liver enzyme rose significantly in the oxymetholone group, but the number of values greater than three times the upper limit of normal were not different between these groups.
    CONCLUSIONS:

    In hemodialysis patients, ingesting oxymetholone was associated with an increase in fat-free mass, handgrip strength, and muscle mRNA levels for several growth factors and a decrease in fat mass, but it also induced liver injury.


    PMID:23124786 [PubMed - indexed for MEDLINE]
    PMCID:PMC3562853 [Available on 2014/2/7]

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    heavyiron nice info..thanks,,so if im understanding what al this says in a nutshell is that i could run this at say eight weeks 50-100 mg per day,,how muh of my gaings strength and muscle weight am i going to keep, after done ,,thanks oldschoolman51

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