Nolvadex
(Tamoxifen Citrate)
Tamoxifen is an antagonist of the estrogen receptor in breast tissue. It has been the standard endocrine (anti-estrogen) therapy for hormone-positive early breast cancer, although aromatase inhibitors have been proposed for postmenopausal women. Some breast cancer cells require estrogen to grow. Estrogen binds to and activates the estrogen receptor in these cells. Tamoxifen is metabolized into compounds that also bind to the estrogen receptor but do not activate it. Furthermore tamoxifen prevents estrogen from binding to its receptor. Hence breast cancer cell growth is blocked.Tamoxifen is a SERM.
Selective Estrogen Receptor Modulators (SERMs) are a class of compounds that act on the estrogen receptor. A characteristic that distinguishes these substances from pure receptor agonists and antagonists is that their action is different in various tissues, thereby granting the possibility to selectively inhibit or stimulate estrogen-like action in various tissues.
Nolvadex essentially blocks the action of estrogen in certain tissues like breast tissue. This is advantageous to males because Tamoxifen is an effective way to prevent gynocomastia. A daily dose of 20mg will typically protect a male from gyno. I always like to keep a bottle of Tamoxifen on hand for emergency gyno treatment as it is one of the fastest ways to mitigate gyno syptoms.
In addition to blocking the action of estrogen, Tamoxifen also increases testosterone, LH, FSH and estrogen. Estrogen is of course blocked in certain tissues leaving a circulating amount that may be beneficial to lipids. I personally would use a low dose aromatase inhibitor alongside Tamoxifen if employing it for PCT as Tamoxifen may raise E2 so much that it causes an abnormal T/E2 ratio. Users with an abnormal T/E2 ratio may benefit from a long-term cotreatment with aromatase inhibitors.
Tamoxifen is a versatile compound that may be prescribed for gyno, testosterone recovery and even for fertility in males.
~heavyiron~
(Tamoxifen Citrate)
Tamoxifen is an antagonist of the estrogen receptor in breast tissue. It has been the standard endocrine (anti-estrogen) therapy for hormone-positive early breast cancer, although aromatase inhibitors have been proposed for postmenopausal women. Some breast cancer cells require estrogen to grow. Estrogen binds to and activates the estrogen receptor in these cells. Tamoxifen is metabolized into compounds that also bind to the estrogen receptor but do not activate it. Furthermore tamoxifen prevents estrogen from binding to its receptor. Hence breast cancer cell growth is blocked.Tamoxifen is a SERM.
Selective Estrogen Receptor Modulators (SERMs) are a class of compounds that act on the estrogen receptor. A characteristic that distinguishes these substances from pure receptor agonists and antagonists is that their action is different in various tissues, thereby granting the possibility to selectively inhibit or stimulate estrogen-like action in various tissues.
Nolvadex essentially blocks the action of estrogen in certain tissues like breast tissue. This is advantageous to males because Tamoxifen is an effective way to prevent gynocomastia. A daily dose of 20mg will typically protect a male from gyno. I always like to keep a bottle of Tamoxifen on hand for emergency gyno treatment as it is one of the fastest ways to mitigate gyno syptoms.
In addition to blocking the action of estrogen, Tamoxifen also increases testosterone, LH, FSH and estrogen. Estrogen is of course blocked in certain tissues leaving a circulating amount that may be beneficial to lipids. I personally would use a low dose aromatase inhibitor alongside Tamoxifen if employing it for PCT as Tamoxifen may raise E2 so much that it causes an abnormal T/E2 ratio. Users with an abnormal T/E2 ratio may benefit from a long-term cotreatment with aromatase inhibitors.
Tamoxifen is a versatile compound that may be prescribed for gyno, testosterone recovery and even for fertility in males.
~heavyiron~
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