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  1. #16
    Chemistry Experiment
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    In the cancer subjects that upregulation of PGR occurs, 100% see down regulation after 4 weeks of Nolva.

    Cancer Res. 1981 May;41(5):1984-8.

    Effects of tamoxifen on estrogen and progesterone receptors in human breast cancer.

    Waseda N, Kato Y, Imura H, Kurata M.


    Twenty patients with primary breast cancer were treated with tamoxifen (10 mg p.o. twice a day) for 1 to 4 weeks. Before and after the tamoxifen administration, tumor specimens were obtained and assayed for estrogen receptors and progesterone receptors (PGR). Total cytosol estrogen receptor (ERC) and occupied nuclear estrogen receptor (ERN) were measured by hydroxylapatite assay, and unoccupied PGR was measured by the dextran-coated charcoal assay. ERC, ERN, and PGR were detectable in 11, 8, and 6 tumors, respectively, before tamoxifen administration. After tamoxifen treatment, ERC decreased in 10 of 11 ERC-positive tumors. Occupied ERN increased in three of five ERN-positive tumors treated with tamoxifen for a short period (1 to 2 weeks), but they decreased in all of three ERN-positive tumors after longer administration (3 to 4 weeks). PGR increased in three of five ERN-positive tumors after short-term tamoxifen treatment, but they decreased in all of three tumors treated by the drug for a longer period. Increased PGR responses were accompanied by an increase of ERN in two of three ERN-positive tumors. These results suggest that tamoxifen interacts with the estrogen receptor system in human breast cancer tissue and may be estrogenic during short treatment, while longer treatment results in an antiestrogenic response.

    PMID:7214366 [PubMed - indexed for MEDLINE]

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  2. #17
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    Great read heavy..................when i see guys in the gym[where i work ]..that are fat...guys in their 40's to 60' with that blubbery fat.....i think clomid or nolva might really
    help......and young boys with 'bitch tit's'........but you can't suggest they use clomid or have to tell them to go to the doctor.....

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