First Cycle and PCT (updated 2012)

Results 1 to 12 of 12
  1. #1
    Chemistry Experiment
    ADMINISTRATOR
    heavyiron's Avatar


    Join Date
    Dec 2009
    Gender
    Male
    Location
    Staying Anabolic
    Posts
    15,430

    Thanks Thanks Given 
    40
    Thanks Thanks Received 
    83
    Thanked in
    59 Posts
    Rep Points
    2147483647


    First Cycle and PCT (updated 2012)

    The effects of Testosterone



    One of the most common question I'm asked is "what should I do for a first cycle?" The questions are; "what steroid should I take?" "How long should I take it?"? and "What will the effects be?" There are literally dozens of steroids available and that makes it difficult for a first time user to choose. The following information will attempt to provide enough information for a first time user to make an educated decision about anabolic androgenic steroid use.

    Testosterone is one of the most effective, safe and available steroids today, therefore I believe Testosterone is the best first cycle choice. The following text outlines the benefits and risks of Testosterone administration based on a clinical human trial of 61 healthy men in 2001. The purpose of the trial was to determine the dose dependency of testosterone's effects on fat-free mass and muscle performance. In this trial 61 men, 18-35years old were randomized into 5 groups receiving weekly injections of 25, 50, 125, 300, 600 mg of Testosterone Enanthate for 20 weeks. They had previous weight-lifting experience and normal T levels. Their nutritional intake was standardized and they did not undertake any strength training during the trial. The only two groups that reported significant muscle building benefits were the 300 and 600 mg groups so any dose lower than 300mg will not be considered in this essay. 12 men participated in the 300 mg group and 13 men in the 600 mg group.



    600mg of Testosterone a week for 20 weeks resulted in the following benefits. Increased fat free mass, muscle strength, muscle power, muscle volume, hemoglobin and IGF-1.

    The same 600 mg administration resulted in 2 side effects. HDL cholesterol was negatively correlated and 2 men developed acne.

    The normal range for total T in men is 241-827 ng/dl according to Labcorp and 260-1000 ng/dl according to Quest Laboratories. The normal range for IGF-1 is 81-225 according to Labcorp. Total T and IGF-1 levels were taken after 16 weeks and resulted in the following;

    Total Testosterone
    300 mg group-1,345 ng/dl a 691 ng increase from baseline
    600 mg group-2,370 ng/dl a 1,737 ng increase from baseline

    IGF-1
    300 mg group-388 ng/dl a 74 ng increase from baseline
    600 mg group-304 ng/dl a 77 ng increase from baseline

    Body composition was measured after 20 weeks.

    Fat Free Mass by underwater weighing
    300 mg group-5.2kg (11.4lbs) increase
    600 mg group-7.9kg (17.38lbs) increase

    Fat Mass by underwater weighing
    300 mg group-.5kg (1.1lbs) decrease
    600 mg group-1.1kg (2.42lbs) decrease

    Thigh Muscle Volume
    300 mg group-84 cubic centimeter increase
    600 mg group-126 cubic centimeter increase

    Quadriceps Muscle Volume
    300 mg group-43 cubic centimeter increase
    600 mg group-68 cubic centimeter increase

    Leg Press Strength
    300 mg group-72.2kg (158.8lbs) increase
    600 mg group-76.5kg (168.3lbs) increase

    Leg Power
    300 mg group-38.6 watt increase
    600 mg group-48.1 watt increase

    Hemoglobin
    300 mg group-6.1 gram per liter increase
    600 mg group-14.2 gram per liter increase

    Plasma HDL Cholesterol
    300 mg group-5.7 mg/dl decrease
    600 mg group-8.4 mg/dl decrease

    Acne
    300 mg group-7 of the 12 men developed acne
    600 mg group-2 of the 13 men developed acne

    There were no significant changes in PSA or liver enzymes at any dose up to 600mg. However, long-term effects of androgen administration on the prostate, cardiovascular risk, and behavior are unknown. The study demonstrated that there is a dose dependent relationship with testosterone administration. In other words the more testosterone administered the greater the muscle building effects and potential for side effects.

    Given the results of the study and based on years of personal experience I believe the first time user can safely use between 300-600 mg of testosterone enanthate or cypionate per week for 8-12 weeks. Because it is desirable to have even blood androgen levels I advise at least 2 equal injections per week. The following graph demonstrates that testosterone cypionate peaks within 1-2 days after injection and falls off to almost baseline by day 10. Therefore waiting 7 days between injections of cypionate would cause wide fluctuations in blood androgen levels.

    Pharmacokinetics of Testosterone cypionate Injection


    Source: Schulte-Beerbuhl, 1980 Figure. Pharmacokinetics of 200mg Testosterone cypionate injection. Source: Comparison of Testosterone, dihydrotestosterone, luteinizing hormone, and follicle-stimulating hormone in serum after injection of Testosterone enanthate or Testosterone cypionate. Schulte-Beerbuhl M, Nieschlag E. Fertility and Sterility 33 (1980) 201-3.

    If a first time user wanted to use 600 mg of cypionate or enanthate per week he would inject 300 mg on Tuesday and another 300 mg on Saturday each week for 10 weeks. When injecting long heavy esters like cypionate with this frequency I tend to have less acne then 1 injection per week.

    There are a number of esters which provide varying release times. Acetate or propionate esters extend the release time of testosterone a couple of days. In contrast, a deconate ester prolongs the release of testosterone about 3 weeks. Testosterone enanthate and cypionate are almost identical esters. The use of an ester allows for a less frequent injection schedule than using a water based testosterone like suspension which has no ester at all and is rapidly in and out of your system after injection. The published release times are not exact and are many times based on a single injection not many multiple injections which can delay the release of the hormone. Other factors affect release times of esters such as scar tissue and the muscle group injected. Only a blood test can confirm when the active hormone has cleared your system.

    Esters not only effect release times but also the potency of the Testosterone as esters make up part of the steroid weight. This must be taken into account when calculating dosages. The longer the release time the less free hormone. For example propionate is about 15% more potent mg. for mg. then enanthate so 500mg of propionate would equal about 575 mg. of enanthate. The following chart illustrates the free base equivalents for several compounds.



    Although it was not indicated in the trial, during or after the steroid cycle some men are prone to gynecomastia which is the formation of female like breast tissue. This is due to excessive estrogen as the body tries to balance out the sex hormones. A selective estrogen receptor modulator or S.E.R.M. such as Tamoxifen can be used effectively to combat gynecamastia in an emergency as it competes for the estrogen receptor which in turn inhibits estrogen's effects. It is highly recommended that a S.E.R.M. be available during treatment of Testosterone. 10-40mg daily is an effective dose however dosage is dependent on how much testosterone is administered as well as the individual himself.

    The decision to use steroids should not be taken lightly and should be the last consideration after implementing a solid nutritional, training and recovery plan. It is advised to get blood work when using these medications.



    Ancillaries during the cycle



    Aromatase Inhibitor


    I briefly wrote about using Tamoxifen above for emergency gynecomastia treatment however I'm convinced that there is a better strategy for controlling estrogen during a steroid cycle. Rather than waiting for the side effects of estrogen to present an aromatase inhibitor like Arimidex or Aromasin should be used on cycle to control Estrogen and keep free testosterone levels high. 0.5mg-1mg Arimidex every other day OR 10-25mg Aromasin daily. Start with the lower dose and then see how that controls water retention, blood pressure and libido and make adjustments as needed. A blood test would be the most ideal way to determine the dosage of the AI. Free T needs to be in the high range and estradiol between 10-30 pg/ml.


    Human Chorionic Gonadotropin


    Testosterone-Induced gonadotropin suppression tends to cause atrophy of the testes and decreases intratesticular testosterone. In other words, when a male administers testosterone his testes shrink because they are suppressed. A simple way to restore ITT levels and maintain the mass of the testes is to administer HCG during testosterone treatment. During a study it was determined that HCG is dose dependent and that approximately 300iu HCG taken every other day restored ITT levels. This is 1,050iu HCG weekly. I recommend 500iu twice weekly while on testosterone treatment. HCG will not only keep ITT levels and the mass of the testes normal but will also aid in keeping the male fertile.


    Sample cycle with ancillaries


    Sunday 10mg Aromasin
    Monday 10mg Aromasin/500iu HCG
    Tuesday 10mg Aromasin/300mg Enanthate
    Wednesday 10mg Aromasin
    Thursday 10mg Aromasin
    Friday 10mg Aromasin/500iu HCG
    Saturday 10mg Aromasin/300mg Enanthate


    For all you guys who want to add multiple compounds to your first course I advise against it because if you have side effects then you will not know which compound is causing the sides. I have gotten a ton of questions over the years and there is always some reason that I'm given for using multiple compounds on the first run but there really is no need. However my cycle sample above may not be for everyone so I am offering an alternative to the flat cycle design. If you want to run a first cycle with a little more horsepower then you may want to consider a modified pyramiding cycle. I have done over 20 pyramid courses and must say they are my favorite way to run aas. The human body is always fighting for homeostasis so the concept is to increase dose before gains plateau. Based on the 2009 myostatin study we can design a cycle that is effective for 10 weeks using this strategy. The following first cycle is for men that want a little more performance with added risk while only using Testosterone. The first 5 weeks a standard dose is administered to evaluate how your body responds and to determine if sides are manageable. If sides are manageable then increase the dose.

    Sample first course #2

    Week 1-5 600mg Testosterone weekly
    Week 6-8 800mg Testosterone weekly
    Week 9-10 1 gram Testosterone weekly

    10-25 mg Aromasin daily with the goal of keeping Estradiol between 10pg/ml-30pg/ml. Only blood work can confirm if you are in this range.

    500iu HCG twice weekly.


    Post Cycle therapy


    I strongly believe that an AI should be used as long as there is an aromatizing compound being administered. In this case Testosterone and HCG aromatize therefore using an AI until these meds clear is what I'm recommending. Nolvadex has been shown to reduce IGF-1 and GH levels when used alone. This is not a big deal on cycle as testosterone increases IGF-1 in a dose dependent relationship. However off cycle this is may be a problem. PCT is a fragile time and lower IGF-1 and GH levels are not desirable. More advanced users may opt to use Nolvadex and Human Growth Hormone during PCT to counter the HGH lowering effect of Nolvedex. However, I'm recommending AI's that may be used on cycle and during PCT. It's my conclusion that Aromasin or Arimidex are both good choices.

    I recommend the following PCT protocol for esters like Cypionate and Enanthate;

    While the aas ester is clearing : 2500iu HCG every third day for 2 weeks. (You may use less HCG if your testes are normal in size AND you have been using HCG on cycle, i.e. 1,000iu HCG every third day.)

    100/100/100/50 Clomid (50mg taken twice per day weeks 1-3 AFTER the aas ester clears)

    20mg/20mg/20mg Aromasin (20mg daily for 3 weeks)

    3g Vit C every day split in 3 doses

    10g creatine daily

    The HCG is administered BEFORE the aas ester clears to increase the mass of the testes and bring back ITT levels. This will allow the testes to sustain output of testosterone sooner.

    Clomid is universally accepted as THE testosterone recovery tool. It blocks estrogen from the HPTA and stimulates the production of GNRH then initiates the production of LH, which in turn signals the testis (if not atrophied) to produce testosterone.

    Aromasin or a similar aromatase inhibitor is for testosterone recovery and it is used to keep the testosterone/estrogen balance in favor of testosterone. It is also helps to keep any additionally occurring estrogen from HCG low to none.

    Cortisol is catabolic. It is the enemy of all anabolism and must be kept in check. While it is blocked when under the influence of AAS, it is free to attach to the Anabolic Receptors (AR) once the steroids leave. Due to this blockage Cortisol tends to accumulate and increase when on. A low level is desirable however since it is important for other vital functions such as control of inflammation. Balance is the key. Vitamin C keeps the exercise induced rise of Cortisol in check.

    The use of Creatine has shown to increase ATP metabolism and cellular water storage among many other things. This is beneficial because it provides for heightened nutrient storage and a slight increase in anabolism as well as workout stamina.

    Failed Post Cycle Therapy
    Sometimes a single post cycle therapy is insufficient to restore healthy testosterone levels and a second post cycle therapy may be needed. In that case I would advise a simple clomid HPTA restart at 50mg daily for 4-6 weeks.

    References
    1.Testosterone dose-response relationships in healthy young men;
    2.Pharmacokinetics and Dose Finding of a Potent Aromatase Inhibitor, Aromasin (Exemestane), in Young Males
    3.Low-Dose Human Chorionic Gonadotropin Maintains Intratesticular Testosterone in Normal Men with Testosterone-Induced Gonadotropin Suppression
    4.Use of clomiphene citrate to reverse premature andropause secondary to steroid abuse.
    5.Changes in the Endocrinological Milieu After Clomiphene Citrate Treatment for Oligozoospermia: The Clinical Significance of the Estradiol/Testosterone Ratio as a Prognostic Value

    6.Testicular steroidogenesis after human chorionic gonadotropin desensitization in rats.

    7.Effect of tamoxifen on GH and IGF-1 serum level in stage I-II breast cancer patients
    8.Treatment of gynecomastia with tamoxifen: A double-blind crossover study
    9.Role of testosterone/estradiol ratio in predicting the efficacy of tamoxifen citrate treatment in idiopathic oligoasthenoteratozoospermic men.



    special thanks to those men and women who have influnced my thinking over the years in regards to aas use.

    Written by heavyiron
    Attached Images Attached Images
    Last edited by heavyiron; 09-06-2011 at 05:05 AM.

    IronMag Labs 15% Off Coupon Code = heavyiron15


    milehigh15 coupon code for 15% off!



    heavyiron15 for 15% off at IronMagResearch

    All posts are for entertainment and may contain fiction. Consult a medical doctor before using any medications or supplements. Heavyiron does not advocate readers engage in any illegal activity.

  2. #2
    Chemistry Experiment
    ADMINISTRATOR
    heavyiron's Avatar


    Join Date
    Dec 2009
    Gender
    Male
    Location
    Staying Anabolic
    Posts
    15,430

    Thanks Thanks Given 
    40
    Thanks Thanks Received 
    83
    Thanked in
    59 Posts
    Rep Points
    2147483647


    Testosterone cypionate

    Testosterone is the hormone that makes men, well, men! In this Profile, we´ll take a look at testosterone cypionate, and examine the pros and cons of its use to improve performance in athletics and bodybuilding.

    Testosterone is the hormone responsible for many different physical and mental characteristics in males. It promotes sex drive, fat loss, helps with gaining and maintaining lean muscle mass and bone density and may even protect against heart disease.(1) All other steroids are actually the testosterone molecule that has been altered to change the properties of the hormone. This would make testosterone the "father" of all other steroids employed by athletes today. In fact, testosterone is the standard for the anabolic/androgenic ratio we use, it´s a "perfect" 100 score, against which we measure all other steroids.

    As I previously stated, testosterone is a highly anabolic and androgenic hormone, it has an anabolic (muscle building) rating of 100, making it a good drug to use if one is in pursuit of more size and strength. And if you aren´t in pursuit of more size and strength, then why would you be reading this, right? Well, let´s get on with it and look at exactly what makes testosterone a good mass builder. Firstly, testosterone promotes nitrogen retention in the muscle (2) the more nitrogen the muscles holds the more protein the muscle stores. Testosterone can also increase the levels of another anabolic hormone, IGF-1, in muscle tissue (3). Testosterone also has the amazing ability to increase the activity of satellite cells (4). These cells play a very active role in repairing damaged muscle. Testosterone also binds to the androgen receptor to promote A.R dependant mechanisms for muscle gain and fat loss, (5) it also significantly increases the concentrations of the A. R in cells critical for muscle repair and growth and A.R in muscle.(4, 6 ). Testosterone induces changes in shape, size and also can change the appearance and the number of muscle fibers (7). Androgens like testosterone can protect your hard earned muscle from the catabolic (muscle wasting) glucocorticoid hormones (8), thus inhibiting the actions of them. In addition, Testosterone has the ability to increase red blood cell production (9), and a higher RBC count may improve endurance via better oxygenated blood. More RBCs can also improve recovery from strenuous physical activity. As you may have suspected, Testosterones´ anabolic/androgenic effects are dose dependant, the higher the dose the higher the muscle building effect (10).

    Users report massive strength gains while using testosterone (11). Testosterone improves muscle contraction by increasing the number of motor neutrons in muscle (4) and improves neuromuscular transmission (12). It also promotes glycogen synthesis (13) providing more fuel for intense workouts thus increasing endurance and strength. Also note that the water retention from testosterone use will cause the muscle to spring back when compressed during the lowering of a weight. Testosterone promotes aggressive and dominant behavior (14), this would explain the boost of confidence which gives athletes the mental edge they need to move the heavy iron.

    Testosterone is also good at promoting fat loss. Having an anti-estrogenic effect it creates an ideal fat loss environment. Test binds to the A.R on fat cells resulting in fat break-down and also prevents new fat formation.(15) Another indirect action of fat loss that test produces is the nutrient portioning effect it has on muscle and fat. Since the body is building muscle at an accelerated rate more of the food you eat is shuttled to muscle tissue and away from fat.

    Is there anything testosterone can´t do?

    Side effects of Testosterone Cypionate

    Testosterone use does have some unwanted side effects that users should be aware of. Testosterone can convert to the female hormone estrogen (via aromatization) by the aromatize enzyme. Excessive estrogen can lead to some nasty side effects. Breast tissue growth in men (gynecomastia), fat gain and reduced fat breakdown, loss of sex drive, testicular shrinkage and water retention. Water retention can increase blood pressure weakening blood vessels over a period of time. The use of a class of drugs to stop the testosterone from converting to estrogen called aromatize inhibitors can easily stop the estrogenic side effects. The use of HCG during a testosterone cycle can prevent the testicular shrinkage. Testosterone can also interact with the 5 alpha-reductase enzyme. This action converts the testosterone to Dihydro-testosterone (DHT), a more androgenic form of the parent hormone. DHT has a high binding affinity to the tissues of the scalp resulting in hair loss in loss in users who suffer from male pattern baldness. DHT can affect the prostate as well, making it swell. This swelling can cause the gland to press against the bladder causing urinary problems. Drugs called 5alpha-reductase inhibitors can prevent these symptoms without blocking testosterone´s anabolic effects.(16) Higher dosages of test can also negatively impact cholesterol, lowering HDL(17), constantly ignoring this can lead to a series of serious health problems down the road.

    Testosterone levels decrease as we age with level dramatically falling at 50-60 years of age(18). Low test levels leads to loss of muscle mass and strength, gains in fat and loss of sex drive (18). So it is a good idea to replace testosterone with an outside source. Supplementing testosterone in older adults with sub-optimal levels may prevent or delay Alzheimer´s disease and other cognitive diseases, protect nerves, regenerate motor units, improves mood, memory, appetite, sex drive, improve bone mass and decrease the risk of heart attack and stroke(19) (20)(21)(22). This shows that test replacement significantly improves quality of life and may be a good option for middle-aged men. Caution should be taken when using higher dosages because of an increased risk of adverse side effects.(23)

    Testosterone cypionate is an injectable oil which contains testosterone with the cypionate ester attached to the testosterone molecule. The ester denotes the release pattern of the test after it is injected into the body. This particular ester gives the testosterone an active life of 15-16 days, although blood levels of this drug fall sharply five days post-administration, testosterone levels are still above baseline after a week (24). Stable blood levels can be achieved with once per week injections. users often administer the drug twice weekly or every three to five days days. On a funny side note, many steroid users believe that test cyp is more or less powerful than the other popular injectable testosterone enanthate. The truth is, they are almost identical in release patterns, so there is virtually no difference between the two. However, as far back as the printing of the first Underground Steroid Handbook, there has been speculation that Cyp had more "kick" than Enth.

    Testosterone is highly versatile and should be considered the "base" of anabolic/androgenic steroid cycles because of its muscle building potential as well as for the fact that it prevents the loss of sex drive that sometime affects those who neglect to use it with other HPTA suppressive anabolics, (especially the 19-nor family). Test can be used for any body building goal whether it´s fat loss or muscle gain. An excellent drug for beginners it´s also cheap making it a top-notch choice for anyone interested in utilizing anabolics to reach their bodybuilding or athletic goals. With regards to this particular version of testosterone, you should be paying no more than $75 for a 10cc bottle of it, dosed at 200mgs/ml. Of course, as usual, prices fluctuate, but I´d recommend sticking with a reputable underground lab, rather then Organon, UpJohn, or one of the many other expensive (and often counterfeited) companies.

    Testosterone Cypionate Profile

    17b-hydroxy-4-androsten-3-one
    Testosterone base + cypionate ester
    Formula: C27 H40 O3
    Molecular Weight: 412.6112
    Molecular Weight (base): 288.429
    Molecular Weight (ester): 132.1184
    Formula (base): C19 H28 O2
    Formula (ester): C8 H14 O2
    Melting Point (base): 155
    Melting Point (ester): 98 - 104 C
    Manufacturer: Various
    Effective Dose (Men): 300-2000mg+ week
    Effective Dose (Women): Not recommended
    Active life: 15-16 days
    Detection Time: 3 months
    Anabolic/Androgenic ratio:100/100.


    References:

    1. Heart. 2004 Aug;90(8):871-6.
    2. J Clin Endocrinol Metab. 1997 Feb;82(2):407-13.
    3. Am J Physiol Endocrinol Metab. 2002 Mar;282(3):E601-7.
    4. Curr Opin Clin Nutr Metab Care. 2004 May;7(3):271-7.
    5. Curr Pharm Biotechnol. 2004 Oct;5(5):459-70.
    6. J Clin Endocrinol Metab. 2004 Oct;89(10):5245-55.
    7. Anat Histol Embryol. 2003 Apr;32(2):70-9.
    8. J Lab Clin Med. 1995 Mar;125(3):326-33.
    9. Zhonghua Nan Ke Xue. 2003;9(4):248-51
    10. J Clin Endocrinol Metab. 2003 Apr;88(4):1478-85
    11. steriod.com/forums
    12. J Appl Physiol. 2001 Mar;90(3):850-6.
    13. Can J Physiol Pharmacol. 1999 Apr;77(4):300-4.
    14. Health Psychol. 1990;9(6):774-91.
    15. Biochim Biophys Acta. 1995 May 11;1244(1):117-20.
    16. Am J Physiol Endocrinol Metab. 2005 Jan;288(1):E222-E227. Epub 2004 Sep 14.
    17. J Clin Endocrinol Metab. 2004 Dec 21
    18. Sports Med. 2004;34(12):809-24.
    19. Heart. 2004 Aug;90(8):871-6.
    20. Pol J Pharmacol. 2004 Sep-Oct;56(5):509-18.
    21. Proc Natl Acad Sci U S A. 2002 Feb 5;99(3):1140-5. Epub 2002 Jan 22.
    22. J Gerontol A Biol Sci Med Sci. 2001 May;56(5):M266-72.
    23. J Clin Endocrinol Metab. 2005 Feb;90(2):678-88. Epub 2004 Nov 23.
    24. Fertility and Sterility 33. (1980) 201-3

    IronMag Labs 15% Off Coupon Code = heavyiron15


    milehigh15 coupon code for 15% off!



    heavyiron15 for 15% off at IronMagResearch

    All posts are for entertainment and may contain fiction. Consult a medical doctor before using any medications or supplements. Heavyiron does not advocate readers engage in any illegal activity.

  3. #3
    Chemistry Experiment
    ADMINISTRATOR
    heavyiron's Avatar


    Join Date
    Dec 2009
    Gender
    Male
    Location
    Staying Anabolic
    Posts
    15,430

    Thanks Thanks Given 
    40
    Thanks Thanks Received 
    83
    Thanked in
    59 Posts
    Rep Points
    2147483647


    This proves that testosterone is dose dependant. In other words the more you use the more it works to increase IGF-1, strength, fat free mass, size and power.


    Vol. 281, Issue 6, E1172-E1181, December 2001

    Testosterone dose-response relationships in healthy young men

    Shalender Bhasin1, Linda Woodhouse1, Richard Casaburi3, Atam B. Singh1, Dimple Bhasin3, Nancy Berman3, Xianghong Chen4, Kevin E. Yarasheski4, Lynne Magliano2, Connie Dzekov1, Jeanne Dzekov1, Rachelle Bross3, Jeffrey Phillips3, Indrani Sinha-Hikim1, Ruoquing Shen1, and Thomas W. Storer2

    1 Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R. Drew University of Medicine and Science, Los Angeles 90059; 2 Laboratory for Exercise Sciences, El Camino College, and 3 Harbor-University of California Los Angeles Medical Center, Torrance, California 90502; and 4 Biomedical Mass Spectrometric Research Resource, Department of Internal Medicine, Washington University, School of Medicine, St. Louis, Missouri 63110

    ABSTRACT

    Testosterone increases muscle mass and strength and regulates other physiological processes, but we do not know whether testosterone effects are dose dependent and whether dose requirements for maintaining various androgen-dependent processes are similar. To determine the effects of graded doses of testosterone on body composition, muscle size, strength, power, sexual and cognitive functions, prostate-specific antigen (PSA), plasma lipids, hemoglobin, and insulin-like growth factor I (IGF-I) levels, 61 eugonadal men, 18-35 yr, were randomized to one of five groups to receive monthly injections of a long-acting gonadotropin-releasing hormone (GnRH) agonist, to suppress endogenous testosterone secretion, and weekly injections of 25, 50, 125, 300, or 600 mg of testosterone enanthate for 20 wk. Energy and protein intakes were standardized. The administration of the GnRH agonist plus graded doses of testosterone resulted in mean nadir testosterone concentrations of 253, 306, 542, 1,345, and 2,370 ng/dl at the 25-, 50-, 125-, 300-, and 600-mg doses, respectively. Fat-free mass increased dose dependently in men receiving 125, 300, or 600 mg of testosterone weekly (change +3.4, 5.2, and 7.9 kg, respectively). The changes in fat-free mass were highly dependent on testosterone dose (P = 0.0001) and correlated with log testosterone concentrations (r = 0.73, P = 0.0001). Changes in leg press strength, leg power, thigh and quadriceps muscle volumes, hemoglobin, and IGF-I were positively correlated with testosterone concentrations, whereas changes in fat mass and plasma high-density lipoprotein (HDL) cholesterol were negatively correlated. Sexual function, visual-spatial cognition and mood, and PSA levels did not change significantly at any dose. We conclude that changes in circulating testosterone concentrations, induced by GnRH agonist and testosterone administration, are associated with testosterone dose- and concentration-dependent changes in fat-free mass, muscle size, strength and power, fat mass, hemoglobin, HDL cholesterol, and IGF-I levels, in conformity with a single linear dose-response relationship. However, different androgen-dependent processes have different testosterone dose-response relationships.

    IronMag Labs 15% Off Coupon Code = heavyiron15


    milehigh15 coupon code for 15% off!



    heavyiron15 for 15% off at IronMagResearch

    All posts are for entertainment and may contain fiction. Consult a medical doctor before using any medications or supplements. Heavyiron does not advocate readers engage in any illegal activity.

  4. #4
    Chemistry Experiment
    ADMINISTRATOR
    heavyiron's Avatar


    Join Date
    Dec 2009
    Gender
    Male
    Location
    Staying Anabolic
    Posts
    15,430

    Thanks Thanks Given 
    40
    Thanks Thanks Received 
    83
    Thanked in
    59 Posts
    Rep Points
    2147483647


    Vol. 283, Issue 1, E154-E164, July 2002

    Testosterone-induced increase in muscle size in healthy young men is associated with muscle fiber hypertrophy

    Indrani Sinha-Hikim1, Jorge Artaza1, Linda Woodhouse1, Nestor Gonzalez-Cadavid1, Atam B. Singh1, Martin I. Lee1, Thomas W. Storer1, Richard Casaburi2, Ruoquing Shen1, and Shalender Bhasin1

    1 Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R. Drew University of Medicine and Science, Los Angeles, 90059; and 2 Division of Respiratory and Critical Care Physiology and Medicine, Harbor-University of California at Los Angeles Medical Center, Torrance, California 90509

    ABSTRACT

    Administration of replacement doses of testosterone to healthy hypogonadal men and supraphysiological doses to eugonadal men increases muscle size. To determine whether testosterone-induced increase in muscle size is due to muscle fiber hypertrophy, 61 healthy men, 18-35 yr of age, received monthly injections of a long-acting gonadotropin-releasing hormone (GnRH) agonist to suppress endogenous testosterone secretion and weekly injections of 25, 50, 125, 300, or 600 mg testosterone enanthate (TE) for 20 wk. Thigh muscle volume was measured by magnetic resonance imaging (MRI) scan, and muscle biopsies were obtained from vastus lateralis muscle in 39 men before and after 20 wk of combined treatment with GnRH agonist and testosterone. Administration of GnRH agonist plus TE resulted in mean nadir testosterone concentrations of 234, 289, 695, 1,344, and 2,435 ng/dl at the 25-, 50-, 125-, 300-, and 600-mg doses, respectively. Graded doses of testosterone administration were associated with testosterone dose and concentration-dependent increase in muscle volume measured by MRI (changes in vastus lateralis volume, 4, +7, +15, +32, and +48 ml at 25-, 50-, 125-, 300-, and 600-mg doses, respectively). Changes in cross-sectional areas of both type I and II fibers were dependent on testosterone dose and significantly correlated with total (r = 0.35, and 0.44, P < 0.0001 for type I and II fibers, respectively) and free (r = 0.34 and 0.35, P < 0.005) testosterone concentrations during treatment. The men receiving 300 and 600 mg of TE weekly experienced significant increases from baseline in areas of type I (baseline vs. 20 wk, 3,176 ± 186 vs. 4,201 ± 252 µm2, P < 0.05 at 300-mg dose, and 3,347 ± 253 vs. 4,984 ± 374 µm2, P = 0.006 at 600-mg dose) muscle fibers; the men in the 600-mg group also had significant increments in cross-sectional area of type II (4,060 ± 401 vs. 5,526 ± 544 µm2, P = 0.03) fibers. The relative proportions of type I and type II fibers did not change significantly after treatment in any group. The myonuclear number per fiber increased significantly in men receiving the 300- and 600-mg doses of TE and was significantly correlated with testosterone concentration and muscle fiber cross-sectional area. In conclusion, the increases in muscle volume in healthy eugonadal men treated with graded doses of testosterone are associated with concentration-dependent increases in cross-sectional areas of both type I and type II muscle fibers and myonuclear number. We conclude that the testosterone induced increase in muscle volume is due to muscle fiber hypertrophy.

    IronMag Labs 15% Off Coupon Code = heavyiron15


    milehigh15 coupon code for 15% off!



    heavyiron15 for 15% off at IronMagResearch

    All posts are for entertainment and may contain fiction. Consult a medical doctor before using any medications or supplements. Heavyiron does not advocate readers engage in any illegal activity.

  5. #5
    Chemistry Experiment
    ADMINISTRATOR
    heavyiron's Avatar


    Join Date
    Dec 2009
    Gender
    Male
    Location
    Staying Anabolic
    Posts
    15,430

    Thanks Thanks Given 
    40
    Thanks Thanks Received 
    83
    Thanked in
    59 Posts
    Rep Points
    2147483647


    Not only does Testosterone make your muscles bigger but it also is associated with more satellite cells.




    Testosterone-induced muscle hypertrophy is associated with an increase in satellite cell number in healthy, young men

    Indrani Sinha-Hikim,1 Stephen M. Roth,2 Martin I. Lee,1 and Shalender Bhasin1

    1Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R. Drew University of Medicine and Science, Los Angeles, California 90059; and 2Department of Human Genetics, University of Pittsburgh, Pittsburgh, Pennsylvamia 15261
    Submitted 22 August 2002 ; accepted in final form 26 March 2003

    ABSTRACT


    Testosterone (T) supplementation in men induces muscle fiber hypertrophy. We hypothesized that T-induced increase in muscle fiber size is associated with a dose-dependent increase in satellite cell number. We quantitated satellite cell and myonuclear number by using direct counting and spatial orientation methods in biopsies of vastus lateralis obtained at baseline and after 20 wk of treatment with a gonadotropin-releasing hormone agonist and a 125-, 300-, or 600-mg weekly dose of T enanthate. T administration was associated with a significant increase in myonuclear number in men receiving 300- and 600-mg doses. The posttreatment percent satellite cell number, obtained by direct counting, differed significantly among the three groups (ANCOVA P < 0.000001); the mean posttreatment values (5.0 and 15.0%) in men treated with 300- and 600-mg doses were greater than baseline (2.5 and 2.5%, respectively, P < 0.05 vs. baseline). The absolute satellite cell number measured by spatial orientation at 20 wk (1.5 and 4.0/mm) was significantly greater than baseline (0.3 and 0.6/mm) in men receiving the 300- and 600-mg doses (P < 0.05). The change in percent satellite cell number correlated with changes in total (r = 0.548) and free T concentrations (r = 0.468). Satellite cell and mitochondrial areas were significantly higher and the nuclear-to-cytoplasmic ratio lower after treatment with 300- and 600-mg doses. We conclude that T-induced muscle fiber hypertrophy is associated with an increase in satellite cell number, a proportionate increase in myonuclear number, and changes in satellite cell ultrastructure.

    IronMag Labs 15% Off Coupon Code = heavyiron15


    milehigh15 coupon code for 15% off!



    heavyiron15 for 15% off at IronMagResearch

    All posts are for entertainment and may contain fiction. Consult a medical doctor before using any medications or supplements. Heavyiron does not advocate readers engage in any illegal activity.

  6. #6
    Chemistry Experiment
    ADMINISTRATOR
    heavyiron's Avatar


    Join Date
    Dec 2009
    Gender
    Male
    Location
    Staying Anabolic
    Posts
    15,430

    Thanks Thanks Given 
    40
    Thanks Thanks Received 
    83
    Thanked in
    59 Posts
    Rep Points
    2147483647


    In this study 600mg per week of Testosterone Enanthate increased the number of Androgen Receptors in healthy men after 20 weeks of administration.


    Androgen Receptor in Human Skeletal Muscle and Cultured Muscle Satellite Cells: Up-Regulation by Androgen Treatment

    Indrani Sinha-Hikim, Wayne E. Taylor, Nestor F. Gonzalez-Cadavid, Wei Zheng and Shalender Bhasin
    Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R. Drew University of Medicine and Science, Los Angeles, California 90059

    Address all correspondence and requests for reprints to: Shalender Bhasin, M.D., Charles R. Drew University of Medicine and Science, 1731 East 120th Street, Los Angeles, California 90059. E-mail: sbhasin@ucla.edu.


    Abstract

    Androgens stimulate myogenesis, but we do not know what cell types within human skeletal muscle express the androgen receptor (AR) protein and are the target of androgen action. Because testosterone promotes the commitment of pluripotent, mesenchymal cells into myogenic lineage, we hypothesized that AR would be expressed in mesenchymal precursor cells in the skeletal muscle. AR expression was evaluated by immunohistochemical staining, confocal immunofluorescence, and immunoelectron microscopy in sections of vastus lateralis from healthy men before and after treatment with a supraphysiological dose of testosterone enanthate. Satellite cell cultures from human skeletal muscle were also tested for AR expression. AR protein was expressed predominantly in satellite cells, identified by their location outside sarcolemma and inside basal lamina, and by CD34 and C-met staining. Many myonuclei in muscle fibers also demonstrated AR immunostaining. Additionally, CD34+ stem cells in the interstitium, fibroblasts, and mast cells expressed AR immunoreactivity. AR expression was also observed in vascular endothelial and smooth muscle cells. Immunoelectron microscopy revealed aggregation of immunogold particles in nucleoli of satellite cells and myonuclei; testosterone treatment increased nucleolar AR density. In enriched cultures of human satellite cells, more than 95% of cells stained for CD34 and C-met, confirming their identity as satellite cells, and expressed AR protein. AR mRNA and protein expression in satellite cell cultures was confirmed by RT-PCR, reverse transcription and real-time PCR, sequencing of RT-PCR product, and Western blot analysis. Incubation of satellite cell cultures with supraphysiological testosterone and dihydrotestosterone concentrations (100 nM testosterone and 30 nM dihydrotestosterone) modestly increased AR protein levels. We conclude that AR is expressed in several cell types in human skeletal muscle, including satellite cells, fibroblasts, CD34+ precursor cells, vascular endothelial, smooth muscle cells, and mast cells. Satellite cells are the predominant site of AR expression. These observations support the hypothesis that androgens increase muscle mass in part by acting on several cell types to regulate the differentiation of mesenchymal precursor cells in the skeletal muscle.

    Full study;

    http://jcem.endojournals.org/cgi/con...ull/89/10/5245

    IronMag Labs 15% Off Coupon Code = heavyiron15


    milehigh15 coupon code for 15% off!



    heavyiron15 for 15% off at IronMagResearch

    All posts are for entertainment and may contain fiction. Consult a medical doctor before using any medications or supplements. Heavyiron does not advocate readers engage in any illegal activity.

  7. #7
    Chemistry Experiment
    ADMINISTRATOR
    heavyiron's Avatar


    Join Date
    Dec 2009
    Gender
    Male
    Location
    Staying Anabolic
    Posts
    15,430

    Thanks Thanks Given 
    40
    Thanks Thanks Received 
    83
    Thanked in
    59 Posts
    Rep Points
    2147483647


    J Clin Endocrinol Metab. 2006 Aug;91(8):3024-33. Epub 2006 May 16.

    Effects of testosterone supplementation on skeletal muscle fiber hypertrophy and satellite cells in community-dwelling older men.

    Sinha-Hikim I, Cornford M, Gaytan H, Lee ML, Bhasin S.
    Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R. Drew University, Los Angeles, CA 90059, USA.

    Abstract

    OBJECTIVE: In this study, we determined the effects of graded doses of testosterone on muscle fiber cross-sectional area (CSA) and satellite cell number and replication in older men.
    PARTICIPANTS: Healthy men, 60-75 yr old, received a long-acting GnRH agonist to suppress endogenous testosterone production and 25, 50, 125, 300, or 600 mg testosterone enanthate im weekly for 20 wk.
    METHODS: Immunohistochemistry, light and confocal microscopy, and electron microscopy were used to perform fiber typing and quantitate myonuclear and satellite cell number in vastus lateralis biopsies, obtained before and after 20 wk of treatment.
    RESULTS: Testosterone administration in older men was associated with dose-dependent increases in CSA of both types I and II fibers. Satellite cell number increased dose dependently at the three highest doses (3% at baseline vs. 6.2, 9.2, and 13.0% at 125, 300, and 600 mg doses, P < 0.05). Testosterone administration was associated with an increase in the number of proliferating cell nuclear antigen+ satellite cells (1.8% at baseline vs. 3.9, 7.5, and 13% at 125, 300, and 600 mg doses, P < 0.005). The expression of activated Notch, examined only in the 300-mg group (baseline, 2.3 vs. 9.0% after treatment, P < 0.005), increased in satellite cells after testosterone treatment. The expression of myogenin (baseline, 6.2 vs. 20.7% after treatment, P < 0.005), examined only in the 300-mg group, increased significantly in muscle fiber nuclei after testosterone treatment, but Numb expression did not change.
    CONCLUSIONS: Older men respond to graded doses of testosterone with a dose-dependent increase in muscle fiber CSA and satellite cell number. Testosterone-induced skeletal muscle hypertrophy in older men is associated with increased satellite cell replication and activation.


    PMID: 16705073 [PubMed - indexed for MEDLINE]

    IronMag Labs 15% Off Coupon Code = heavyiron15


    milehigh15 coupon code for 15% off!



    heavyiron15 for 15% off at IronMagResearch

    All posts are for entertainment and may contain fiction. Consult a medical doctor before using any medications or supplements. Heavyiron does not advocate readers engage in any illegal activity.

  8. #8
    Chemistry Experiment
    ADMINISTRATOR
    heavyiron's Avatar


    Join Date
    Dec 2009
    Gender
    Male
    Location
    Staying Anabolic
    Posts
    15,430

    Thanks Thanks Given 
    40
    Thanks Thanks Received 
    83
    Thanked in
    59 Posts
    Rep Points
    2147483647


    J Clin Endocrinol Metab. 2010 Jun;95(6):2560-75.

    Clinical review 1: Adverse effects of testosterone therapy in adult men: a systematic review and meta-analysis.

    Fernández-Balsells MM, Murad MH, Lane M, Lampropulos JF, Albuquerque F, Mullan RJ, Agrwal N, Elamin MB, Gallegos-Orozco JF, Wang AT, Erwin PJ, Bhasin S, Montori VM.
    Knowledge and Encounter Research Unit, Mayo Clinic, Rochester, Minnesota 55905, USA.

    Abstract

    CONTEXT: The risks of testosterone therapy in men remain poorly understood.
    OBJECTIVE: The aim of this study was to conduct a systematic review and meta-analyses of testosterone trials to evaluate the adverse effects of testosterone treatment in men.
    DATA SOURCES: We searched MEDLINE, EMBASE, and Cochrane CENTRAL from 2003 through August 2008. Review of reference lists and contact with experts further identified candidate studies.
    STUDY SELECTION: Eligible studies were comparative, randomized, and nonrandomized and reported the effects of testosterone on outcomes of interest (death, cardiovascular events and risk factors, prostate outcomes, and erythrocytosis). Reviewers, working independently and in duplicate, determined study eligibility.
    DATA EXTRACTION: Reviewers working independently and in duplicate determined the methodological quality of studies and collected descriptive, quality, and outcome data.
    DATA SYNTHESIS: The methodological quality of the 51 included studies varied from low to medium, and follow-up duration ranged from 3 months to 3 yr. Testosterone treatment was associated with a significant increase in hemoglobin [weighted mean difference (WMD), 0.80 g/dl; 95% confidence interval (CI), 0.45 to 1.14] and hematocrit (WMD, 3.18%; 95% CI, 1.35 to 5.01), and a decrease in high-density lipoprotein cholesterol (WMD, -0.49 mg/dl; 95% CI, -0.85 to -0.13). There was no significant effect on mortality, prostate, or cardiovascular outcomes.
    CONCLUSIONS: The adverse effects of testosterone therapy include an increase in hemoglobin and hematocrit and a small decrease in high-density lipoprotein cholesterol. These findings are of unknown clinical significance. Current evidence about the safety of testosterone treatment in men in terms of patient-important outcomes is of low quality and is hampered by the brief study follow-up.


    PMID: 20525906 [PubMed - indexed for MEDLINE]

    IronMag Labs 15% Off Coupon Code = heavyiron15


    milehigh15 coupon code for 15% off!



    heavyiron15 for 15% off at IronMagResearch

    All posts are for entertainment and may contain fiction. Consult a medical doctor before using any medications or supplements. Heavyiron does not advocate readers engage in any illegal activity.

  9. #9
    Chemistry Experiment
    ADMINISTRATOR
    heavyiron's Avatar


    Join Date
    Dec 2009
    Gender
    Male
    Location
    Staying Anabolic
    Posts
    15,430

    Thanks Thanks Given 
    40
    Thanks Thanks Received 
    83
    Thanked in
    59 Posts
    Rep Points
    2147483647


    J Clin Endocrinol Metab. 1986 Dec;63(6):1361-4.

    Pharmacokinetic properties of testosterone propionate in normal men.

    Fujioka M, Shinohara Y, Baba S, Irie M, Inoue K.

    Abstract

    The pharmacokinetic characteristics of testosterone propionate were studied in normal men after a single im dose of 25 mg testosterone propionate-19,19,19-d3. Plasma levels of testosterone propionate-19,19,19-d3, its active metabolite testosterone-19,19,19-d3, and endogenous testosterone were measured by gas chromatography-mass spectrometry. Testosterone propionate-19,19,19-d3 was gradually transferred from the im injection site to the systemic circulation. The plasma levels of testosterone propionate-19,19,19-d3 were maintained at 2-4 ng/ml between 3 and 36 h after administration. Plasma testosterone-19,19,19-d3 levels were maintained above the physiological testosterone level for 48 h, while plasma levels of endogenous testosterone changed little.

    PMID: 3782423 [PubMed - indexed for MEDLINE]

    Last edited by heavyiron; 07-10-2011 at 07:38 AM.

    IronMag Labs 15% Off Coupon Code = heavyiron15


    milehigh15 coupon code for 15% off!



    heavyiron15 for 15% off at IronMagResearch

    All posts are for entertainment and may contain fiction. Consult a medical doctor before using any medications or supplements. Heavyiron does not advocate readers engage in any illegal activity.

  10. #10
    www.TrannyUrine.com/
    BOARD REP
    SFW's Avatar


    Join Date
    Dec 2009
    Gender
    Male
    Location
    w/Geared Jesus ♂
    Age
    87
    Posts
    9,441

    Thanks Thanks Given 
    0
    Thanks Thanks Received 
    1
    Thanked in
    1 Post
    Rep Points
    2147483647


    Acne

    300 mg group-7 of the 12 men developed acne

    600 mg group-2 of the 13 men developed acne


    More gear = less acne? I knew it all along.
    http://www.TrannyUrine.com/
    Use promo Code
    HIV20 for 20% off!


  11. #11
    Chemistry Experiment
    ADMINISTRATOR
    heavyiron's Avatar


    Join Date
    Dec 2009
    Gender
    Male
    Location
    Staying Anabolic
    Posts
    15,430

    Thanks Thanks Given 
    40
    Thanks Thanks Received 
    83
    Thanked in
    59 Posts
    Rep Points
    2147483647


    The Effects of Injected Testosterone Dose and Age on the Conversion of Testosterone to Estradiol and Dihydrotestosterone in Young and Older Men



    - Author Affiliations

    • Division of Endocrinology, Diabetes, and Nutrition, and Boston Claude D. Pepper Older Americans Independence Center for Function Promoting Therapies (K.M.L., T.G.T., S.Ba., P.E.K., S.Bh.), Boston University School of Medicine, Boston Medical Center, Boston, Massachusetts 02118; Lahey Clinic Medical Center (B.K.), Burlington, Massachusetts 01805; Charles Drew University (A.B.S.), Los Angeles, California 90059; Department of Biostatistics (T.G.T., M.P.L.), Boston University School of Public Health, Boston, Massachusetts 02118; and Hoffman LaRoche (N.A.M.), CH-4070 Basel, Switzerland


    • Address all correspondence and requests for reprints to: Kishore M. Lakshman, M.D., M.P.H., Division of Endocrinology, Diabetes and Nutrition, Boston University School of Medicine, Boston Medical Center, 670 Albany Street, Second Floor, Boston, Massachusetts 02118. E-mail: Kishore.Lakshman@bmc.org.


    Abstract

    Background: During testosterone (T) therapy, T is partly converted to 17β-estradiol (E2) and 5α-dihydrotestosterone (DHT). Effects of age, testosterone dose, and body composition on total and free E2 and DHT levels are unknown.
    Objective: We evaluated age and dose-related differences in E2 and DHT levels in response to graded doses of testosterone enanthate in young and older men.
    Methods: Fifty-one young (aged 19–35 yr) and 52 older (aged 59–75 yr) men completed treatment with monthly injections of a GnRH agonist plus randomly assigned weekly doses of testosterone enanthate (25, 50, 125, 300, or 600 mg) for 5 months.
    Results: During testosterone administration, total and free E2 levels increased dose-dependently (dose effect, P < 0.001) in both young and older men. Total and free E2 levels and E2:T ratios during T administration were higher in older than young men, but age-related differences in free E2 and free E2:T ratios were not significant after adjusting for testosterone levels, percentage fat mass, and SHBG. DHT levels and DHT:T ratios were dose-related but did not differ between young and older men. Mechanistic modeling of free hormone data revealed that the conversions of T to E2 and DHT were both consistent with saturable Michaelis-Menten kinetics. The in vivo Km values were estimated to be 1.83 nm for aromatase and 3.35 nm for 5α-reductase, independent of age. The Vmax parameter for E2 was 40% higher in older men than younger men, but Vmax for DHT was not significantly different between age groups.
    Conclusions: During im testosterone administration, E2 and DHT levels exhibit saturable increases with dose. The rate of whole body aromatization is higher in older men, partly related to their higher percentage fat mass, SHBG, and testosterone levels.

    IronMag Labs 15% Off Coupon Code = heavyiron15


    milehigh15 coupon code for 15% off!



    heavyiron15 for 15% off at IronMagResearch

    All posts are for entertainment and may contain fiction. Consult a medical doctor before using any medications or supplements. Heavyiron does not advocate readers engage in any illegal activity.

  12. #12
    Chemistry Experiment
    ADMINISTRATOR
    heavyiron's Avatar


    Join Date
    Dec 2009
    Gender
    Male
    Location
    Staying Anabolic
    Posts
    15,430

    Thanks Thanks Given 
    40
    Thanks Thanks Received 
    83
    Thanked in
    59 Posts
    Rep Points
    2147483647


    J Clin Endocrinol Metab. 2005 Feb;90(2):678-88. Epub 2004 Nov 23.
    Older men are as responsive as young men to the anabolic effects of graded doses of testosterone on the skeletal muscle.

    Bhasin S, Woodhouse L, Casaburi R, Singh AB, Mac RP, Lee M, Yarasheski KE, Sinha-Hikim I, Dzekov C, Dzekov J, Magliano L, Storer TW.
    Source

    Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R. Drew University of Medicine and Science, University of California, Los Angeles, CA 90059, USA. sbhasin@ucla.edu

    Abstract

    Although testosterone levels and muscle mass decline with age, many older men have serum testosterone level in the normal range, leading to speculation about whether older men are less sensitive to testosterone. We determined the responsiveness of androgen-dependent outcomes to graded testosterone doses in older men and compared it to that in young men. The participants in this randomized, double-blind trial were 60 ambulatory, healthy, older men, 60-75 yr of age, who had normal serum testosterone levels. Their responses to graded doses of testosterone were compared with previous data in 61 men, 19-35 yr old. The participants received a long-acting GnRH agonist to suppress endogenous testosterone production and 25, 50, 125, 300, or 600 mg testosterone enanthate weekly for 20 wk. Fat-free mass, fat mass, muscle strength, sexual function, mood, visuospatial cognition, hormone levels, and safety measures were evaluated before, during, and after treatment. Of 60 older men who were randomized, 52 completed the study. After adjusting for testosterone dose, changes in serum total testosterone (change, -6.8, -1.9, +16.1, +49.5, and +101.9 nmol/liter at 25, 50, 125, 300, and 600 mg/wk, respectively) and hemoglobin (change, -3.6, +9.9, +20.9, +12.6, and +29.4 g/liter at 25, 50, 125, 300, and 600 mg/wk, respectively) levels were dose-related in older men and significantly greater in older men than young men (each P < 0.0001). The changes in FFM (-0.3, +1.7, +4.2, +5.6, and +7.3 kg, respectively, in five ascending dose groups) and muscle strength in older men were correlated with testosterone dose and concentrations and were not significantly different in young and older men. Changes in fat mass correlated inversely with testosterone dose (r = -0.54; P < 0.001) and were significantly different in young vs. older men (P < 0.0001); young men receiving 25- and 50-mg doses gained more fat mass than older men (P < 0.0001). Mood and visuospatial cognition did not change significantly in either group. Frequency of hematocrit greater than 54%, leg edema, and prostate events were numerically higher in older men than in young men. Older men are as responsive as young men to testosterone's anabolic effects; however, older men have lower testosterone clearance rates, higher increments in hemoglobin, and a higher frequency of adverse effects. Although substantial gains in muscle mass and strength can be realized in older men with supraphysiological testosterone doses, these high doses are associated with a high frequency of adverse effects. The best trade-off was achieved with a testosterone dose (125 mg) that was associated with high normal testosterone levels, low frequency of adverse events, and significant gains in fat-free mass and muscle strength.


    PMID: 15562020 [PubMed - indexed for MEDLINE]

    IronMag Labs 15% Off Coupon Code = heavyiron15


    milehigh15 coupon code for 15% off!



    heavyiron15 for 15% off at IronMagResearch

    All posts are for entertainment and may contain fiction. Consult a medical doctor before using any medications or supplements. Heavyiron does not advocate readers engage in any illegal activity.

Similar Threads

  1. Arimidex~Anastrozole (updated 2012)
    By heavyiron in forum Ancillary Profiles
    Replies: 9
    Last Post: 06-16-2013, 07:18 PM
  2. 1st Cycle - Updated
    By ambiti in forum Anabolic Zone
    Replies: 14
    Last Post: 08-20-2011, 03:46 PM
  3. Replies: 1
    Last Post: 06-12-2006, 09:37 AM

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •  
Copyright© 2001-2017 IronMag® Bodybuilding Forums