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Less Frequent Testosterone Injections: Testosterone Buciclate and Undecanoate

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  1. #1
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    Less Frequent Testosterone Injections: Testosterone Buciclate and Undecanoate

    Less Frequent Testosterone Injections: Testosterone Buciclate and Undecanoate
    by Nelson Vergel

    This long acting testosterone injectable ester last longer than other injectable any in the body. For this reason, it has been studied by the World Health Organization as a male contraceptive, since testosterone injections can lower sperm counts and this option would require fewer injections per year. The studies were done in the 1990′s but no pharmaceutical company picked up the rights in the United States. A search in clinicaltrails.gov found no current studies. Some internet sites sell the product but I do not know their quality. It is illegal to order testosterone or anabolic steroids on the internet in the United States, even for people with HIV who have a prescription. Although it is almost impossible for customs to intercept all packages, it does happen. You may not go to jail but will have a warning sent to your house as they intercept and throw away your order.

    This testosterone ester stays in the body for a few weeks after one injection. A study done using intramuscular injection of 600 mg of T buciclate to hypogonadal men produced serum testosterone concentrations within the normal range for about 8 weeks with a terminal elimination half- life of 29.5 days (day when only half of the product remains in the body) . Serum dehydrotestosterone (DHT) concentrations were within the normal range; estradiol was only slightly increased above normal; sex hormone binding globulin (SHBG) did not change; and gonadotropins (LH and FSH) were significantly suppressed. No adverse biochemical or prostate responses were re- ported. It is unknown if this preparation will find use for male contraceptive therapy or replacement for hypogonadism.


    TESTOSTERONE UNDECANOATE

    This option may get approve within the next few months in the United States with the brand name Aveed. It is sold in many countries as Nebido.

    Intramuscular injections of 500 and 1000 mg of testosterone undecanoate (TU) in hypogonadal men resulted in increased mean serum T levels from less than 10 nmol/L to 47.8 and 54.2 nmol/L, respectively, after about 1 week. Thereafter, serum T levels decreased progressively and reached the lower-normal limit for adult men by day 50 and 60 and had a terminal elimination half-life of 18.3 and 23.7 days, respectively. Estradiol and DHT followed the pattern of T and remained within normal limits. In these short-term studies, no serious side effects were noted.

    Aveed will most probably get approved after the company proves that the coughing caused by the injections in a few people is not related to the product but to injection technique. Anaphylactic reactions are common side effects with all approved testosterone injectables due to bad injection technique, so it is amazing that the FDA delayed the approval of Aveed based on a side effect that is well known with currently available testosterone products in the United States. Common symptoms of anaphylactic reactions with testosterone injections are cough and dizziness that subside after a few minutes. It is believed that this happens when testosterone enters the blood stream and ends up in the lungs (injections are meant to form a “pocket” for slow release in the muscle. Some people may inject in a blood vessel and have anaphylactic reactions). I have had this reaction and found a quick solution to it: breathe into a paper bag until the cough stops.

    source


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  2. #2
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    I'm sure many here would pin it EOD.


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    Quote Originally Posted by Big Pimpin View Post
    I'm sure many here would pin it EOD.

    Lol werd
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    its often used in Sustanon which happens to be one of my favorites.


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  5. #5
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    Quote Originally Posted by Prince View Post
    its often used in Sustanon which happens to be one of my favorites.
    I do too but many seem to hate on it.



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    Not that many hate it but it is harder to maintain a steady blood level than a basic Test E or C. Sust can be great if used with frequent injections.



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    Quote Originally Posted by Big Pimpin View Post
    I do too but many seem to hate on it.


    I used to hate on it until I tried it.

    test is test, but the effect seems different. Less bloat for me.

    M/W/F pins work ok.
    " A cookie without sugar is just a cracker" ~ ancient voodoo proverb
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