Lose the red wine & optimize the diet. Your results are only as good as the protocol you follow. I don't like the idea of playing around w/ self-medication w/ the existing program isn't already optimized. Sadly one part of getting older is learning to adapt to the changes in your body & metabolism. And to this point, I don't like the idea of setting the expectation of looking to self-medication to make up the difference. You can't then, rely on self-medication every time you want to see results.
I'm in the same boat myself - I just turned 46 and I'm trying to cut 10 lb of lean muscle mass as well as my off-season fluff to compete in a lower category (bodybuilding to women's physique) and I am having to learn how to change up what I'm doing as the stuff I did the last 20 yrs ain't working so good anymore.
I would suggest if you can, post up her diet. It may sound "clean" but it may be lacking in things that are actually hindering her from reaching her goals. The red wine is big fat red flag to me - even if it is intended to be just 1-2 glasses / nite for resveritol value. Also is she getting good quality fat and what are her total cals?