Using Epigenetics
to Prevent Chronic Disease:
Part One
by Bonnie Minsky MA, MPH, LDN, CNS
& Steve Minsky
Introduction
We have always had a unique perspective on chronic disease: in particular, dementia, diabetes, cardiovascular disease, hypertension, and autoimmune disorders: rather than focusing on specific diseases, we feel that in most instances, there is a common thread that ties them together. As nutritionists, we believe that common thread is the fuel we put into our bodies.
Whereas in the traditional diagnostic model, the patient that presents signs and symptoms of inflammation of the joints, depression, headaches, irritable bowel syndrome, high blood sugar, hypertension, cognitive impairment, and skin problems might be seen by a diabetologist, rheumatologist, neurologist, gastroenterologist and dermatologist for each complaint. In our model, we evaluate the interaction of the environment of the patient with their gene potential discover if there is a unifying theme as the triggering factor. This model now has a scientific term: Epigenetics. It is considered the new frontier in the fight against chronic disease.
In a sense, by preventing physiological imbalance by use of web-like rather than linear cause-effect analysis, we have found that it is possible to address many of the presenting complaints simultaneously with diet and nutrients. While not as fancy as Epigenetics, we call it the "whole health approach."
For example, exploring how nutritional environment influences the insulin signaling process takes on a whole new meaning. Recently, it has been brought to the medical community's attention that insulin is more than a hormone that regulates insulin through its influence on genetic expression, but also insulin signaling itself is regulated through a complex network of kinase enzymes that translate information from outside the cell to its interior including the genome and mitochondria. The fact that kinases are intimately affected by dietary influences as well as exercise and stress hormones opens up a brand new science-based approach towards prevention.
The process, simply put, works like this:
1) Food Molecule encounters Kinase Hubs
2A) If food molecule is cytotoxic, multiple stressor signals are sent to our book of genes
2B) If food molecule is friendly, multiple calming signals are sent to our book of genes
3A) With constant exposure to stressor signals, polymorphisms (defects) that exist in our genes will be expressed negatively.
3B) With constant exposure to calming signals, polymorphisms (defects) that exist in our genes will be latent.
Science Is At a Crossroads. How Do We Want to Approach Kinase Therapy?
Big Pharma's approach will not be how to make kinases function more harmoniously, but how to block their function. As we found with long-term COX-2 inhibitor use, the side effects using this approach are not desirable. Some experts believe that kinases, like bacteria that have come resistant to antibiotics, will over time become resistant to blockage, or will simply re-route their signals through other kinases that are not blocked. With kinase modification drugs expected to reach $58 billion by 2010, up from $12.7 billion in 2005, Big Pharma had better be right.
The nutritionist approach is different. We want to work with kinases, not against them. Kinases, like our genes, have evolved over time. They know how to utilize powerful substances in our environment to submit calming signals. We are aware that many macro and micronutrients, especially phytochemicals in plants, achieve this effect. We know this because for plants to have survived droughts, floods, and other catastrophic events, they had to develop chemicals for their own survival. Does it not make sense that humans have evolved with plants? That our kinases have been able to synthesize plants' defense mechanisms for our own gain?
While science is now just beginning to understand which molecules are the most effective, three substances have emerged as being kinase-friendly. You may have heard of them
Phytochemicals
These potent substances are prevalent in every part of a plant, but most notably make up the colors in fruits and vegetables. Two nutraceuticals by Metagenics, Insinase and Kaprex, are concentrates of botanicals found to be extremely effective on PI3 Kinase, a kinase with the most wide ranging affect in tissues to date. Four other labs worldwide have done research on the same botanicals and have come up with similar conclusions for insulin regulation and inflammation support.
Healthy Oils
EPA/DHA Omega-3's such as fish oil/cod liver oil.
Monounsaturated fats such as olive oil, nuts and seeds.
Vitamin D
Sunlight
Cod Liver Oil
Vitamin D3 supplementation
Could it be that because of decades of nutritional depravity and lack of nutrients that chronic disease has arisen? By not consuming these substances, are we robbing ourselves of kinase calmers and creating chronic disease by negative expression of our genes? Conventional science is finally saying yes.
Think about the hottest issue of the day: American's dearth of fruit and vegetable consumption, vitamin D deficiency epidemic, and imbalance of omega-3 to omega-6 fatty acid ratio. Is there any wonder why chronic disease is rampant? As nutritionists, our goal - heal the molecule, make it harmonious, and make it shine once again - is something we've been doing already for those who have listened.
Conclusion
Many conventional scientists believe that Epigenetics has now complicated the definition of the ideal diet because numerous and diverse dietary components may influence biological processes in many ways. We believe it is the opposite. Complexity is stability. The more complex your diet, the more stable your health will be.
Why healthy, balanced meals?
Complexity is stability.
Why take supplemental magnesium that is crucial for over 300 bodily functions?
Complexity is stability.
Why are empty calories (processed food, sugar) bad and complex calories (fruits, vegetables, whole grains, lean protein) good?
Complexity is stability.
Why do we so fervently recommend the Cytotoxic food blood test? Food intolerants send constant stressor signals to our genes. The blood test can reveal up to 209 foods that we can avoid to calm stressor signals.
Complexity is stability.
We know that chronic illness may be postponed by changes in lifestyle. It has been shown that the physiologic and psychologic markers of aging may be modified and the average age at first infirmity can be raised, thus extending quality of life, and ultimately pushing morbidity further away.
Until recently, practitioners like us feel like we've been going at it alone. However, with the incredible preventative research that is upon us, the hope is that conventional medicine will finally follow suit in demanding radical lifestyle change. Or, they may continue to follow Big Pharma's path. This statement came from a real advertisement: "Good choices and good medicine. That's what Pfizer believes is the best prescription for keeping America healthy."
In the end, it is up to us as individuals as how we will respond to the challenges of making necessary lifestyle changes. Only time will tell if we are successful.
Mid-April's Special Report will reveal Part II of this story: What is Public Health Priority Number One and the Tools for preventing it.
Disclaimer: This column is for information only and no part of its contents should be construed as medical advice or diagnosis. It is always a good idea to consult your doctor before making any dietary and nutrient changes.
© 2007 Nutritional Concepts, Inc.
to Prevent Chronic Disease:
Part One
by Bonnie Minsky MA, MPH, LDN, CNS
& Steve Minsky
Introduction
We have always had a unique perspective on chronic disease: in particular, dementia, diabetes, cardiovascular disease, hypertension, and autoimmune disorders: rather than focusing on specific diseases, we feel that in most instances, there is a common thread that ties them together. As nutritionists, we believe that common thread is the fuel we put into our bodies.
Whereas in the traditional diagnostic model, the patient that presents signs and symptoms of inflammation of the joints, depression, headaches, irritable bowel syndrome, high blood sugar, hypertension, cognitive impairment, and skin problems might be seen by a diabetologist, rheumatologist, neurologist, gastroenterologist and dermatologist for each complaint. In our model, we evaluate the interaction of the environment of the patient with their gene potential discover if there is a unifying theme as the triggering factor. This model now has a scientific term: Epigenetics. It is considered the new frontier in the fight against chronic disease.
In a sense, by preventing physiological imbalance by use of web-like rather than linear cause-effect analysis, we have found that it is possible to address many of the presenting complaints simultaneously with diet and nutrients. While not as fancy as Epigenetics, we call it the "whole health approach."
For example, exploring how nutritional environment influences the insulin signaling process takes on a whole new meaning. Recently, it has been brought to the medical community's attention that insulin is more than a hormone that regulates insulin through its influence on genetic expression, but also insulin signaling itself is regulated through a complex network of kinase enzymes that translate information from outside the cell to its interior including the genome and mitochondria. The fact that kinases are intimately affected by dietary influences as well as exercise and stress hormones opens up a brand new science-based approach towards prevention.
The process, simply put, works like this:
1) Food Molecule encounters Kinase Hubs
2A) If food molecule is cytotoxic, multiple stressor signals are sent to our book of genes
2B) If food molecule is friendly, multiple calming signals are sent to our book of genes
3A) With constant exposure to stressor signals, polymorphisms (defects) that exist in our genes will be expressed negatively.
3B) With constant exposure to calming signals, polymorphisms (defects) that exist in our genes will be latent.
Science Is At a Crossroads. How Do We Want to Approach Kinase Therapy?
Big Pharma's approach will not be how to make kinases function more harmoniously, but how to block their function. As we found with long-term COX-2 inhibitor use, the side effects using this approach are not desirable. Some experts believe that kinases, like bacteria that have come resistant to antibiotics, will over time become resistant to blockage, or will simply re-route their signals through other kinases that are not blocked. With kinase modification drugs expected to reach $58 billion by 2010, up from $12.7 billion in 2005, Big Pharma had better be right.
The nutritionist approach is different. We want to work with kinases, not against them. Kinases, like our genes, have evolved over time. They know how to utilize powerful substances in our environment to submit calming signals. We are aware that many macro and micronutrients, especially phytochemicals in plants, achieve this effect. We know this because for plants to have survived droughts, floods, and other catastrophic events, they had to develop chemicals for their own survival. Does it not make sense that humans have evolved with plants? That our kinases have been able to synthesize plants' defense mechanisms for our own gain?
While science is now just beginning to understand which molecules are the most effective, three substances have emerged as being kinase-friendly. You may have heard of them
Phytochemicals
These potent substances are prevalent in every part of a plant, but most notably make up the colors in fruits and vegetables. Two nutraceuticals by Metagenics, Insinase and Kaprex, are concentrates of botanicals found to be extremely effective on PI3 Kinase, a kinase with the most wide ranging affect in tissues to date. Four other labs worldwide have done research on the same botanicals and have come up with similar conclusions for insulin regulation and inflammation support.
Healthy Oils
EPA/DHA Omega-3's such as fish oil/cod liver oil.
Monounsaturated fats such as olive oil, nuts and seeds.
Vitamin D
Sunlight
Cod Liver Oil
Vitamin D3 supplementation
Could it be that because of decades of nutritional depravity and lack of nutrients that chronic disease has arisen? By not consuming these substances, are we robbing ourselves of kinase calmers and creating chronic disease by negative expression of our genes? Conventional science is finally saying yes.
Think about the hottest issue of the day: American's dearth of fruit and vegetable consumption, vitamin D deficiency epidemic, and imbalance of omega-3 to omega-6 fatty acid ratio. Is there any wonder why chronic disease is rampant? As nutritionists, our goal - heal the molecule, make it harmonious, and make it shine once again - is something we've been doing already for those who have listened.
Conclusion
Many conventional scientists believe that Epigenetics has now complicated the definition of the ideal diet because numerous and diverse dietary components may influence biological processes in many ways. We believe it is the opposite. Complexity is stability. The more complex your diet, the more stable your health will be.
Why healthy, balanced meals?
Complexity is stability.
Why take supplemental magnesium that is crucial for over 300 bodily functions?
Complexity is stability.
Why are empty calories (processed food, sugar) bad and complex calories (fruits, vegetables, whole grains, lean protein) good?
Complexity is stability.
Why do we so fervently recommend the Cytotoxic food blood test? Food intolerants send constant stressor signals to our genes. The blood test can reveal up to 209 foods that we can avoid to calm stressor signals.
Complexity is stability.
We know that chronic illness may be postponed by changes in lifestyle. It has been shown that the physiologic and psychologic markers of aging may be modified and the average age at first infirmity can be raised, thus extending quality of life, and ultimately pushing morbidity further away.
Until recently, practitioners like us feel like we've been going at it alone. However, with the incredible preventative research that is upon us, the hope is that conventional medicine will finally follow suit in demanding radical lifestyle change. Or, they may continue to follow Big Pharma's path. This statement came from a real advertisement: "Good choices and good medicine. That's what Pfizer believes is the best prescription for keeping America healthy."
In the end, it is up to us as individuals as how we will respond to the challenges of making necessary lifestyle changes. Only time will tell if we are successful.
Mid-April's Special Report will reveal Part II of this story: What is Public Health Priority Number One and the Tools for preventing it.
Disclaimer: This column is for information only and no part of its contents should be construed as medical advice or diagnosis. It is always a good idea to consult your doctor before making any dietary and nutrient changes.
© 2007 Nutritional Concepts, Inc.