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Grape Seed Extract protects against prostate cancer

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    Grape Seed Extract protects against prostate cancer






    Grape Seed Extract protects against prostate cancer

    Men who take high doses of Grape Seed Extract over a longer period are 62 percent less likely to develop prostate cancer than men who don't take the supplement. Researchers at the University of Washington discovered this when they tracked 35,000 men aged between 50 and 76 over a period of six years.

    The study, the results of which were published in Nutrition and Cancer, is part of the Vital Study, an epidemiological research project to study the positive effects of long-term supplement use. This particular part of the project focused on prostate cancer.

    The researchers looked at the use of supplements that would be expected to reduce the chance of prostate cancer, such as Grape Seed Extract, chondroitin, Q10, fish oil, garlic, Ginkgo biloba, ginseng, glucosamine and of course saw palmetto.

    Of all these supplements, Grape Seed Extract was the only one that reduced the likelihood of prostate cancer by a statistically significant amount. Users had 41 percent less chance of developing prostate cancer than non-users. Among the long-term users who took higher doses the effect was even stronger.

    Numbers 2 and 3 in the Anti-Prostate Cancer Top Ten are fish oil and ginseng, but neither performed well in this study.



    Grape Seed Extract contains phenols: flavones, phenolic acids and resveratrol. In experiments with prostate cancer cells, Grape Seed Extract and its components inhibit the transcription factor nuclear factor kappa-B, the inflammatory protein interleukine-6 and the biosynthesis of inflammatory factors produced by cyclooxygenase enzymes, thereby blocking the growth of prostate cancer cells.

    This is the first study directed specifically at supplements' ability to protect against prostate cancer. Because not much is known, the researchers are cautious. "Any public health recommendation for grapeseed would require replication of our findings in humans as well as further clarification of mechanisms of action."

    Source:
    Nutr Cancer. 2011 May;63(4):573-82.
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    ADVANCED CYCLE SUPPORT Rx™ contains grape seed extract.





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    Gallic acid is the anti-cancer agent in Grape Seed Extract

    Men who take supplements containing Grape Seed Extract are 62 percent less likely to develop prostate cancer than men who don't, we wrote a few days ago. We've also found a 2009 animal study, which suggests that one of the active ingredients in Grape Seed Extract is gallic acid. Animal tests have shown that this compound gives protection particularly against an androgen-sensitive form of prostate cancer.

    Scientists have been studying the cancer inhibiting properties of Grape Seed Extract for many years. In experiments with cancer cells they have shown that in theory the extract, which you can buy in any drug store or supplements shop, protects against lung cancer [Mol Cell Biochem. 1999 Jun; 196(1-2): 99-108.], intestinal cancer [Clin Cancer Res 2006; 12:6194–6202.] and breast cancer [Breast Cancer Res Treat. 2008 Jun; 109(3): 427-41.].

    The researchers at the University of Colorado Denver have concentrated on the prostate cancer inhibiting characteristics of Grape Seed Extract. They discovered in 2006 that gallic acid is an important bioactive ingredient in this extract. [Carcinogenesis. 2006 Jul; 27(7): 1445-53.] The discovery was not a big surprise, as in-vitro studies have shown that gallic acid may also offer protection against leukaemia. [Clin Cancer Res. 2009 Jan 1; 15(1): 140-9.] The structural formula for gallic acid is shown below.

    Gallic Acid

    In their study, which was published in Pharmaceutical Research in 2009, the researchers implanted two kinds of human cancer cells in athymic nude mice. As a result of a genetic defect in their immune system the mice did not reject the alien cells. The researchers injected half of their test animals with the hormone insensitive DU145 prostate cancer line, and the other half were injected with 22Rv1 prostate cancer cells. The latter does react to testosterone.

    Some test animals were given ordinary drinking water – these were the control groups. The mice in the experimental groups were given water that contained 0.3 or 1 percent gallic acid.





    During the six-week period of the experiment, gallic acid inhibited the growth of the prostate cancer cells. The compound worked best against the testosterone sensitive 22Rv1 prostate cancer cells.

    Gallic acid is not only found in Grape Seed Extract, but also – mostly in the form of gallotannin – in strawberries, pineapple, bananas, lemons, hazelnuts, tea and apple peel.

    "Additional studies to understand other molecular mechanisms which are responsible for its anti-cancer efficacy are warranted to claim gallic acid as potent anti-cancer agent against prostate cancer", the researchers write. The research was funded by the American National Cancer Institute.

    Source:
    Pharm Res. 2009 Sep;26(9):2133-40.
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    Nice find!

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