Hopefully this info below will help some broz understand when others talkabout half lives of aas.
Withinthe community the concept of half-lives is an often misunderstood one. A largepart of this confusion can be attributed to the typically complex explanationsthat accompany this topic. Consequently, I’m going to stay on task and keepthis definition/explanation of half-lives very simple. I won’t segue onto comparisonsand contrasts, nor will I tangent onto the topic of esterification or evendelve in great detail into the body’s process of drug metabolism. There areplenty of writings about those related subjects should you choose to study them,but the topic of this piece is quite simply ‘understanding half-lives’.
Essentially, and often contrary to the traditional explanation, a medication’shalf-life can be an easy reference for the total time a drug remains active (tovarying degrees) within the body. More specifically, this information is usedas a guide for optimizing your dosing schedule in order to avoid unwanted peaksand valleys in medication effects, and the often undesirable which accompanysuch uneven up and down levels.
All medications possess an active life, or total time during which they performtheir curative activities within the body. Each drug, even within the sameclass, has a different (regardless of how similar) chemical structure, whichlargely determines its half-life. From the moment a drug enters the bloodstreamit becomes subject to the three metabolic functions: 1) absorption - work andoperation within the body; 2) degradation - breakdown of its chemical structurein preparation for evacuation; and 3) elimination - evacuation/removal from thebody.
A drug’s half-life is the time in which it takes for the three metabolicprocesses to impact a given drug to the extent that one half (50%) of said drugis no longer present within the body’s system. Again, since drugs have varyingchemical structures this timeframe will also vary. Sometimes there are starksimilarities within classes of drugs, e.g. typically possess what we consider to be shorthalf-lives of often between 4-16 hours. However, this is merely ageneralization over most of the class, as some other types of orals fall outsidethese parameters for different reasons.
This half-life is reduces the drug content by 50% every time it is experienced,i.e. after the first half-life you're at 50%, the second takes you to 25% orhalf of the remaining fifty, the third 12.5%, and so on until the lasthalf-life known as the terminal one occurs...generally accepted as the 8th(below .05%). Although metabolites still exist, thereby making detectionpossible, the drug's actions or active life has effectively ceased. However, aslong as you continue taking a drug prior to the realization of the terminalhalf-life, you reinitiate its property actions thereby resetting the half-lifequotient to a full 100%. Also of importance here is the fact that the moremedication you take the greater the concentration in your blood becomes, untilyou achieve full blood serum saturation. Some people believe achieving fullsaturation somehow alters the half-life principle, but it doesn’t. Saturationhas to do with optimizing the effects you receive from a medication over time,but it still succumbs to the principle of half-life because even though you canhave more of drug in your system (amount-wise), you can never exceed themaximum of 100%. Consequently, whenever you reach the hundred percent mark beit the first drug administration or after taking it for several weeks, monthsor years once the first half-life expires the drug amount is necessarilyreduced to 50%.