Purchase Peptides

          Follow Us on Facebook        Subscribe to us on YouTube        Follow Us on Twitter        IronMagLabs on Instagram        Sign Up for our Newsletter


IGF-1: The Holy Grail for Muscle Growth?

Results 1 to 18 of 18
  1. #1
    Senior Member
    BOARD REP


    Join Date
    Mar 2010
    Gender
    Male
    Location
    UK
    Posts
    748
    Rep Points
    17879214

    Post IGF-1: The Holy Grail for Muscle Growth?






    IGF-1: The Holy Grail for Muscle Growth?


    Created on Sunday, 13 May 2012 15:59
    Written by Dave Palumbo



    User Rating: / 5
    PoorBest


    IGF-1, as the name implies, is an extremely anabolic hormone that has insulin-like actions (i.e. it shuttles nutrients, specifically amino acids and glucose, into the muscle cells where they can then be synthesized into new muscle tissue). When bodybuilders take growth hormone injections, they are not injecting a pure growth stimulus-- they are taking a stimulating or "releasing" factor. It is for this very reason that high dosing of GH is not necessarily going to result in more growth since growth is limited by the amount of IGF-1 that the liver can produce in response to any given dosage of GH. Therefore, it becomes much easier to just administer IGF-1 directly!


    In pursuit of this goal, scientists have found was that IGF-1 circulates in the bloodstream (99%) bound to specific binding proteins. It is the remaining unbound or FREE (1%) of the IGF-1 that actually causes the anticipated muscle cell hyperplasia (the bound 99% is essentially wasted). In order to combat this phenomenon of the binding proteins "stealing" our precious IGF-1, scientists have chemically altered the original IGF-1 molecule and have added chemically bound side chains thus creating a new hormone known as LONG R3 IGF-1 (the LONG R3 refers to the 3 long side chains that have been added to the original molecule). These large, space occupying, side chains are attached to the IGF-1 molecule to prevent these blood-borne binding proteins (BPs) from "snatching" up and inactivating the IGF-1.

    For the last several years, most bodybuilders that were privy enough to get their hands on synthetically produced IGF-1 have been using the Long R3 IGF-1 variety thinking that it will last longer in the body (12 hours as opposed to 20 minutes) and that more of it will available (unbound) to help build and repair muscle. The theory is essentially correct; however, what bodybuilders started noticing after extended usage of Long R3 IGF-1 was that it stopped working as effectively after about 4 weeks. I began to keep notes and I worked out a system by which bodybuilders would inject Long R3 IGF-1 [about 10-20mcg (micrograms)] within 15 minutes following a workout so that the IGF-1 could circulate and locate these newly produced IGF-1 receptors on the damaged muscle cell membranes (These new receptors appear as a direct result of damage induced by intense weight training and muscular trauma). It is at these damaged cells that the body increases the number of IGF-1 receptors so that it can "signal" where the muscle repairs must be performed (this is why muscle cells GROW, preferentially, and not bone tissue or internal organs as rumored). However, as the dosage of IGF-1 increases above the suggested 10-20mcg per day, the IGF-1 muscle cell receptors become saturated and now all this excess IGF-1 goes straight to the highest naturally occurring concentration of IGF-1 receptors-- the extremities (i.e. Feet, hands, and facial bones).

    Additionally, high Long R3 IGF-1 dosing will lead to decreases in muscle cell IGF-1 receptors thus diminishing the results seen with Long R3 IGF-1 usage over time. Therefore, 10-20mcg per day of Long R3 IGF-1 will cause significant muscle cell hyperplasia and it will continue to do so extremely effectively for approximately 30 days. Even with conservative amounts of Long R3 IGF-1, the hormone still stops functioning after a period of time; therefore, I usually suggest that bodybuilders take a 2 week "holiday" off the Long R3 IGF-1 after every 30 day course of administration. Another reason that Long R3 IGF-1 may stop working is that the Long R3 IGF-1 is not an exact match for that found in nature (it has the added side chain), therefore, a person's immune system may launch an immune response (producing neutralizing antibodies) against what it perceives as a foreign human hormone. To combat this phenomenon, some scientists suggest that, instead of using Long R3 IGF-1, you should inject pure, unadulterated, IGF-1 in small amounts (10-20mcg) all day long (perhaps 2-3 times). The need for low dose, frequent injections, is because pure IGF-1 only lasts 20-60minutes in the body and too high of an IGF-1 dose can result in receptor downgrade. On the positive side, when using pure IGF-1, no neutralizing (inactivating) antibodies are produced by the immune system.

    Many people ask me "how and what" to mix the powdered IGF-1 with? Should I add human serum albumin? What about adding dilute acid water? Should I keep my IGF-1 in the freezer? First off, human serum albumin (HSA) is only added to IGF-1 mixtures that will be used in a "serum free environment". Cell culture is a serum free environment. Human blood vessels contain albumin; therefore, it is NOT a serum free environment, as thus you do NOT need to add human serum albumin to your IGF-1 mixture. Secondly, the addition of 0.6% acetic acid (vinegar) to the IGF-1 vial is suggested so that the IGF-1 molecules will not stick to the glass of the vial. Do I suggest using it? No. The amount of IGF-1 that is lost in the crevices of the glass vial is negligent compared to the disaster that can occur if you add too much acetic acid to your IGF-1 solution (it will destroy the entire IGF-1 mixture). Thirdly, IGF-1, unlike growth hormone, CAN be frozen (freezing does not harm the IGF-1 molecule like it does to the complex GH molecule). Why am I telling you this? When you mix up a bottle of powdered IGF-1, instead of just storing it in the refrigerator until its used up (which can be up to 100 days with the 1mg bottles), you should freeze most of it so that it will not degrade as fast. My suggestion is to freeze anything over a thirty-day supply of IGF-1.

    With the wide ranging legal availability of IGF-1 on innumerable peptide websites all over the internet, procuring IGF-1 is no longer the same concern as it was years ago. The question now becomes, who should you purchase it from? My suggestion is to stick with "made in the USA" peptides and purchase them only from reputable websites. Osta-gain.com makes all their peptide domestically (in the United States) and feedback on their quality and customer service has been repeatedly top rated.



  2. #2
    Senior Member
    BOARD REP


    Join Date
    Mar 2010
    Gender
    Male
    Location
    UK
    Posts
    748
    Rep Points
    17879214

    Use code

    IRONMAG25

    At Osta-gain.com to save 25% off

  3. #3
    Senior Member
    BOARD REP


    Join Date
    Mar 2010
    Gender
    Male
    Location
    UK
    Posts
    748
    Rep Points
    17879214

    This is on sale right now!

  4. #4
    Senior Member
    BOARD REP


    Join Date
    Mar 2010
    Gender
    Male
    Location
    UK
    Posts
    748
    Rep Points
    17879214

    USE CODE

    Freedom

    To save 45% off
    !!

  5. #5
    Member
    BOARD REP
    SwoleChamp's Avatar


    Join Date
    Mar 2011
    Gender
    Male
    Location
    United States
    Posts
    321
    Rep Points
    35718068

    Re: IGF-1: The Holy Grail for Muscle Growth?

    Def an addition in my research and yalls product is top notch! Thanks guys!
    SwoleChamp15 for 15% off at IronMagLabs.com

    swolechamp10 for 10% off @ BlackStoneLabs




    Hardcore Peptides 20% Discount Code: SWOLE20

  6. #6
    Senior Member
    ELITE MEMBER
    dirtwarrior's Avatar


    Join Date
    Jun 2011
    Gender
    Male
    Location
    KY
    Posts
    1,000
    Rep Points
    50321411

    great info

  7. #7
    Senior Member
    BOARD REP
    BBPowder's Avatar


    Join Date
    Aug 2012
    Gender
    Male
    Location
    USA
    Posts
    700
    Rep Points
    11159367

    IGF-1: The Holy Grail for Muscle Growth?

    Great information. I believe personally that dosages much higher than mg's or mcg's is when the insane magic would happen.


    Best Regards,
    BBPowder@securenym.net


    Ask for a product and price list!

  8. #8
    Member
    BOARD REP
    osta-president's Avatar


    Join Date
    Jul 2012
    Gender
    Male
    Location
    Osta-Gain
    Posts
    109
    Rep Points
    3448444

    Dave P. recommends his igf1 protcol much like his BBQ cooking slow and low. He does a longer but much lower dose to prevent the receptors from be shut down prematurely.

  9. #9
    Senior Member
    BOARD REP


    Join Date
    Mar 2010
    Gender
    Male
    Location
    UK
    Posts
    748
    Rep Points
    17879214

    New discount code
    use code
    usa35
    to save 35% off everything!!

  10. #10
    Registered User
    teezhay's Avatar


    Join Date
    Dec 2011
    Gender
    Male
    Location
    USA
    Posts
    931
    Rep Points
    67854312

    Haven't used osta-gain's IGF-1 Lr3, but I have used the compound and I'd recommend it to anyone going into PCT, or just looking to add a couple clean pounds. I'm aware Patrick Arnold has said on a couple other boards that IGF-1 lr3 won't do anything for a bodybuilder, but my (admittedly anecdotal) experience would beg to differ. Much success with this.

  11. #11
    Senior Member
    BOARD REP


    Join Date
    Mar 2010
    Gender
    Male
    Location
    UK
    Posts
    748
    Rep Points
    17879214

    Osta-gain has this on sale right NOW!
    Use code

    USA35

    To save 35% OFF

  12. #12
    Senior Member
    BOARD REP


    Join Date
    Mar 2010
    Gender
    Male
    Location
    UK
    Posts
    748
    Rep Points
    17879214


    $59.99
    IGF-1 LR3:Long R3 IGF-1 Receptor Grade 1mg
    Research Purposes Only And Not For Human Consumption

  13. #13
    Member
    BOARD REP
    TREMBO's Avatar


    Join Date
    Jun 2011
    Gender
    Male
    Location
    Brasil
    Posts
    239
    Rep Points
    1235519

    I've ordered some LR3 and DES from osta gain and will soon researching in my mice's calves and soulders (des)... LR3 will be taken SQ daily!

    I'm just waiting the order to arrive and I'll create a new thread.

  14. #14
    Registered User
    MinMaxMuscle's Avatar


    Join Date
    Nov 2010
    Gender
    Male
    Location
    Gears R Us
    Posts
    257
    Rep Points
    31999990

    Quote Originally Posted by teezhay View Post
    Haven't used osta-gain's IGF-1 Lr3, but I have used the compound and I'd recommend it to anyone going into PCT, or just looking to add a couple clean pounds. I'm aware Patrick Arnold has said on a couple other boards that IGF-1 lr3 won't do anything for a bodybuilder, but my (admittedly anecdotal) experience would beg to differ. Much success with this.

    Interesting piece of info.... igf-lr3 has shorter half life than regular igf-1. lr3 cannot be bound by proteins therefore it is susceptible to proteolytic cleavage.

    Also, in order to gain anything from igf apparently, the area of interest has to be exposed to large amounts of igf-1 for long periods of time, by way of catheter



  15. #15
    Registered User
    MinMaxMuscle's Avatar


    Join Date
    Nov 2010
    Gender
    Male
    Location
    Gears R Us
    Posts
    257
    Rep Points
    31999990

    and the discount code is no longer valid.....

  16. #16
    Senior Member
    BOARD REP


    Join Date
    Mar 2010
    Gender
    Male
    Location
    UK
    Posts
    748
    Rep Points
    17879214

    Quote Originally Posted by MinMaxMuscle View Post
    and the discount code is no longer valid.....
    yea that sale is over. We are having a store wide sale right now and the prices are already set so NO CODE is needed.

  17. #17
    Senior Member
    BOARD REP


    Join Date
    Mar 2010
    Gender
    Male
    Location
    UK
    Posts
    748
    Rep Points
    17879214

    rep codes are now in effect

    use any rep codes to get 20% off

    osta-gain.com

  18. #18
    Member
    BOARD REP
    Musclehead33's Avatar


    Join Date
    Sep 2012
    Gender
    Male
    Location
    Osta-nation
    Posts
    53
    Rep Points
    23899






    One of the best peps there is!
    on sale now 40%off
    use code alpha!

Similar Threads

  1. Replies: 0
    Last Post: 06-27-2011, 01:57 PM
  2. Replies: 0
    Last Post: 06-27-2011, 01:52 PM
  3. Replies: 0
    Last Post: 06-27-2011, 01:52 PM
  4. Burn The Fat HOLY GRAIL Promo Launches Today
    By Prince in forum Bodybuilding Gossip
    Replies: 0
    Last Post: 03-03-2010, 12:40 PM
  5. Blood Sugar/Glycemic Index holy grail of weight loss?
    By studen77 in forum Diet & Nutrition
    Replies: 6
    Last Post: 06-26-2006, 06:18 PM

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •  
DISABLED END -->