Purchase Peptides


Intracerebroventricular administration of melanotan II increases insulin sensitivity

Results 1 to 11 of 11
  1. #1
    Member
    BOARD REP
    LabpeRep's Avatar


    Join Date
    Nov 2011
    Gender
    Male
    Location
    Labpe Peptide, www.labpe.com
    Posts
    152
    Rep Points
    6239473

    Intracerebroventricular administration of melanotan II increases insulin sensitivity






    The hypothalamus integrates a multitude of behavioral and metabolic adaptations to food intake and starvation, necessary to maintain fuel homeostasis despite profound environmental variations in nutrient availability [1]. Two types of neuron in the arcuate nucleus of the hypothalamus are of major importance for the control of these processes: neurons co-expressing Agouti-related protein (AgRP) and neuropeptide Y (NPY), and neurons expressing pro-opiomelanocortin (POMC), the molecular precursor of alphamelanocyte-stimulating hormone (α-MSH) [2]. α-MSH binds to and stimulates melanocortin (MC) receptors. In addition to the effect of MC4 receptor activation on insulin sensitivity, decreased insulin concentration after central activation of the melanocortin neuronal circuitry, and increased levels of insulin in MC4 receptor knock-out mice even before the onset of detectable hyperphagia or obesity [3], have been documented. Hence, the study was designed to evaluate the effects of central administration of melanotan II (MTII), an agonist of melanocortin-3/4 receptor, on hepatic and whole-body insulin sensitivity, independent of food intake and body weight.
    Over a period of 24 h, three aliquots into the left lateral ventricle of male C57Bl/6 mice were injected with 225 ng of MTII. The animals had no access to food. The control group was treated with three injections of distilled water. Hyperinsulinaemic?euglycaemic clamp in combination with [3H]glucose infusion were used to measure whole-body and hepatic insulin sensitivity. Glut4 mRNA expression was measured in skeletal muscle.

    In basal state, body weight, glucose, plasma corticosterone, insulin concentrations and NEFA under basal and hyperinsulinaemic conditions did not differ between MTII- and vehicle-treated animals. Under steady-state hyperinsulinaemic conditions, plasma NEFA levels decreased about two-fold while insulin concentrations increased approximately 10-fold as expected. There were no observed differences in insulin, plasma glucose and NEFA levels between MTII- and vehicle-treated mice during hyperinsulinaemia.

    The glucose disposal rate was significantly higher in MTII treated mice. In contrast, hyperinsulinaemia suppressed EGP to a similar extent in MTII and vehicle treated mice.

    mRNA expression of Glut4 Glut4 mRNA expression in skeletal muscle of the MTII-treated group was higher than that of the vehicle-treated mice.
    In conclusion, all these findings demonstrate that central simulation of melanocortin-3/4 receptors modulates insulin sensitivity in a tissue-specific manner, independent of its well-known impact on feeding and body weight.

    References
    1. Schwartz MW, Woods SC, Porte D Jr, Seeley RJ, Baskin DG (2000) Central nervous system control of food intake. Nature 404:661?671
    2. Raposinho PD, White RB, Aubert ML (2003) The melanocortin agonist Melanotan-II reduces the orexigenic and adipogenic effects of neuropeptide Y (NPY) but does not affect the NPY-driven suppressive effects on the gonadotropic and somatotropic axes in the male rat. J Neuroendocrinol 15:173?181
    3. Raposinho PD, White RB, Aubert ML (2003) The melanocortin agonist Melanotan-II reduces the orexigenic and adipogenic effects of neuropeptide Y (NPY) but does not affect the NPY-driven suppressive effects on the gonadotropic and somatotropic axes in the male rat. J Neuroendocrinol 15:173?181


    Two days Special, Melanotan-II (MT-2) 10mg, as low as $12 per vial, New Batch, 99.89% purity


    MS & HPLC REPORTS:

    BATCH PURITY MS REPORT HPLC REPORT
    M120730-L552757 99.49% MS HPLC


    Labpe, U.S. made peptide, shipping worldwide with an average of 5 business days delivery, overnight shipping available for U.S. delivery.
    Sincerely,
    Labpe Chemicals
    Buy CJC 1295, GHRP-6, GHRP-2 at http://www.labpe.com
    Free shipping national wide

    any question? post it at our sub forum
    http://www.ironmagazineforums.com/labpe-peptide/
    Like us on facebook: http://www.facebook.com/labpechem

  2. #2
    Registered User
    teezhay's Avatar


    Join Date
    Dec 2011
    Gender
    Male
    Location
    USA
    Posts
    931
    Rep Points
    67909931

    No clue what intracerebroventricular administration is, but I imagine it has something to do with injecting the stuff directly into your ventricular system, which sounds goddamned awesome.

  3. #3
    Registered User


    Join Date
    Jan 2012
    Gender
    Male
    Location
    usa
    Posts
    58
    Rep Points
    698274

    Great!!!

  4. #4
    senior memeber


    Join Date
    Apr 2011
    Gender
    Male
    Location
    working out
    Posts
    1,666
    Rep Points
    57549223

    wtf does that say or mean in english why is it that everthing to do with pep is so confussing.why can they not but stuff about pep in plain english where normal people know what the fuck your talking about.i read that whole thing and dont know anthing about any of what i read.but know if you wantt to know any thing about gear it is very easy to undersatnd.these companys would be very very smart to start explaning this stuff in more plain to understand ways.

  5. #5
    Senior Member
    BOARD REP
    Digitalash's Avatar


    Join Date
    Mar 2011
    Gender
    Male
    Location
    US
    Posts
    4,086
    Rep Points
    77554866

    These are medical studies bro, not made by the company. Of course they're gonna use medical terminology, its not really meant for the average person to understand but peps aren't really marketed for humans so you can't really expect them to be explained for the average person. Only thing we have to go on are studies and user experience

  6. #6
    Pushing The Limits


    Join Date
    Mar 2012
    Gender
    Male
    Location
    My Favorite Place
    Posts
    1,138
    Rep Points
    184734304

    these studies are meant to sensationalize the product, people are compelled to believe in a product through this marketing strategy, look at advocare, they use medical and science claims for sales strategies and are very successful while their products are far from the best available
    Nvrbdr is created 100% for entertainment purposes and should NOT be taken seriously. Steroid use is illegal without a prescription, always advise with your doctor

  7. #7
    Registered User
    teezhay's Avatar


    Join Date
    Dec 2011
    Gender
    Male
    Location
    USA
    Posts
    931
    Rep Points
    67909931

    Quote Originally Posted by Jimmyusa View Post
    these studies are meant to sensationalize the product, people are compelled to believe in a product through this marketing strategy
    You're being absurd. Of everyone here interested in Labpe's products, nobody is going to inject anything straight into their cerebral ventricles. I can guaran-fucking-tee you that. And if you ask Labpe right now, "Hey bro so I wanted to buy some of your Melanotan-II so I can shoot it straight into my fucking brain, what gauge needle should I use?" you're not going to get any response other than, "Don't you dare use our products in that way."

    So it's really pretty ludicrous of you to suggest Labpe posted this for marketing purposes, when nobody is buying MT-II to use it the same way it was used in this study, nor would Labpe ever want to sell their product to some random dude who intended to do that. People aren't buying MT-II because of this study. They're buying it to get tan. Now drop your conspiracy theories and false equivalencies, because they're ridiculous.

  8. #8
    Pushing The Limits


    Join Date
    Mar 2012
    Gender
    Male
    Location
    My Favorite Place
    Posts
    1,138
    Rep Points
    184734304

    Quote Originally Posted by teezhay View Post
    You're being absurd. Of everyone here interested in Labpe's products, nobody is going to inject anything straight into their cerebral ventricles. I can guaran-fucking-tee you that. And if you ask Labpe right now, "Hey bro so I wanted to buy some of your Melanotan-II so I can shoot it straight into my fucking brain, what gauge needle should I use?" you're not going to get any response other than, "Don't you dare use our products in that way."

    So it's really pretty ludicrous of you to suggest Labpe posted this for marketing purposes, when nobody is buying MT-II to use it the same way it was used in this study, nor would Labpe ever want to sell their product to some random dude who intended to do that. People aren't buying MT-II because of this study. They're buying it to get tan. Now drop your conspiracy theories and false equivalencies, because they're ridiculous.
    Ok, I misspoke on this post, i admit that, I didn't read all of it, sorry Labpe. But no conspiracy theory's here, truth is a lot of supplement companies do exactly what I claimed, and that was what I wanted to communicate, but clearly didn't.
    Anyway, relax, bring it down a notch, the caps in bold make you look mad or something.
    Last edited by NVRBDR; 08-24-2012 at 11:57 PM.
    Nvrbdr is created 100% for entertainment purposes and should NOT be taken seriously. Steroid use is illegal without a prescription, always advise with your doctor

  9. #9
    Registered User


    Join Date
    Jan 2012
    Gender
    Male
    Location
    USA
    Posts
    73
    Rep Points
    898852

    Labpe is wonderful.I am the customer of Labpe.There products are definitely.

  10. #10
    Registered User


    Join Date
    Mar 2012
    Gender
    Male
    Location
    usa
    Posts
    7
    Rep Points
    4191

    bump

  11. #11
    Registered User


    Join Date
    Jan 2012
    Gender
    Male
    Location
    US
    Posts
    66
    Rep Points
    1805749






    Wonderful!

Similar Threads

  1. Insulin Sensitivity and Fat Loss
    By Prince in forum Articles
    Replies: 0
    Last Post: 06-27-2011, 01:52 PM
  2. Replies: 0
    Last Post: 06-21-2011, 06:17 PM
  3. Insulin Sensitivity and Stimulants (PreWO)
    By Life in forum Supplements
    Replies: 3
    Last Post: 02-10-2011, 04:39 PM
  4. PCOS and insulin sensitivity.....anyone?
    By mandypumpkin in forum Diet & Nutrition
    Replies: 4
    Last Post: 04-27-2004, 12:30 PM
  5. Wine and Insulin Sensitivity
    By LAM in forum Diet & Nutrition
    Replies: 13
    Last Post: 05-23-2002, 10:02 AM

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •  
DISABLED END -->