The future of PCT
People are always debating? Clomid, or Nolva.. or Both for Post cycle therapy (PCT) But you might be missing out on something potentially far more important.. IGF-1 (DES)*or*(LR3).
First though lets have a quick look at the arguments for Nolvadex and Clomid.
Nolvadex does promote estrogen in the liver so improving cholesterol, and it does stimulate LH, As for lowering IGF i myself cant find any real evidence to say it does or doesnt, Clomid on the other hand is something i just cant understand being used.
It increases ocular pressure and long term use will cause permanent damage to eyesight.. PERMANENT.
Clomid has also been known to produce a decrease in the LH response to LH releasing hormone
Quote from a study..Treatments with idiopathic oligospermia for six to nine months resulted in a significant increase in gonadotropin testosterone and estradiol levels. A significant increase in sperm density was observed only in subjects with low sperm count below normal basal FSH levels. In cases where sperm density increased, FSH levels decreased, suggesting an inhibitory effect.
You at the end of the day must choose your own weapon or poison? im still undecided.. but there is something you can add that will really help minimize muscle loss and speed recovery which in PCT is essentially the aim of the game.
IGF IN PCT
Research has shown GH to be vitally important in testicular function, but it is generally accepted that the beneficial effects are directly mediated by HGHs conversion to IGF-1 As many of you know, IGF-1 is created in the liver by GH, upon interacting with insulin. So, we will be focusing on the usage and benefits of IGF-1, rather than GH, as it seems more cost effective and directly related to our purpose of optimizing recovery.
In short, IGF-1 increases steroidogenic acute regulatory protein STAR),and cholesterol side chain cleaving enzyme cyp 11A. These are both rate-limiting steps and are critical factors for converting cholesterol into hormones, such as testosterone. IGF-1 also has the ability to increase the concentration of steroidogenic enzymes in the testes, such as 3b HSD. IGF-1 can also increase the testes sensitivity to LH and hCG by increasing the number of LH receptors.
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