Below is some general information in regards to this fine and absolute compound, that seems to be shrouded and underestimate upon the masses..
After reading this basic info below, please continue to read further about a blind study that was conducted with this amazing product.. I've also included some links in which the community has shared or discussed their feedback OR questions and concerns with PROVIRON!
1 x 50 TABS
Mesterolone 50mg/TAB Proviron is an oral DHT steroid compound similar to Masteron. Although it is not an ideal compound for building muscle (actually it is not good at all for this purpose), Proviron is helpful in stacks because of its unique ability to keep the body from turning testosterone into estrogen, thus giving the testosterone a better anabolic effect. This aids the bodybuilder in many ways. First, it helps reduce estrogenic side effects of other steroids water-retention, lowered sex drive, gynocomastia, etc. Also, Proviron can help boost the potency of testosterone in the body by freeing testosterone from its binding to sex hormone-binding globulin (SHBG). Proviron is therefore best stacked with testosterone, which makes taking anti-estrogen compounds unnecessary. However, Proviron can cause high blood pressure so blood pressure medication may be required for those prone to hypertension. Proviron? is the Schering brand name for the oral androgen mesterolone (1 methyl-dihydrotestosterone). Just as with DHT, the activity of this steroid is that of a strong androgen which does not aromatize into estrogen. In clinical situations Proviron is generally used to treat various types of sexual dysfunction, which often result from a low endogenous testosterone level. It can usually reverse problems of sexual disinterest and impotency, and is sometimes used to increase the sperm count. The drug does not stimulate the body to produce testosterone, but is simply an oral androgen substitute that is used to compensate for a lack of the natural male androgen. Although this steroid is strongly androgenic, the anabolic effect of it is considered too weak for muscle building purposes. This is due to the fact that Proviron is rapidly reduced to inactive metabolites in muscle tissue, a trait also characteristic of dihydrotestosterone. The belief that the weak anabolic nature of this compound indicated a tendency to block the androgen receptor in muscle tissue, thereby reducing the gains of other more potent muscle building steroids, should likewise not be taken seriously. In fact due to its extremely high affinity for plasma binding proteins such as SHBG, Proviron may actually work to increase the activity of other steroids by displacing a higher percentage into a free, unbound state. Among athletes Proviron is primarily used as an anti-estrogen. It is believed to act as an anti-aromatase in the body, preventing or slowing the conversion of steroids into estrogen. The result is somewhat comparable to Arimidex (though less profound), the drug acting to prevent the buildup of estrogen in the body. This is in direct contrast to Nolvadex, which only blocks the ability of estrogen to bind and activate receptors in certain tissues. The anti-aromatization effect is preferred, as it is a more direct and efficient means of dealing with the problem of estrogenic side effects. Another disadvantage of Nolvadex is that if discontinued too early, a rebound effect may occur as high serum estrogen levels are again free to take action. This of course could mean a rapid onset of side effects such as gynecomastia. Most actually prefer to use both Proviron and Nolvadex, especially during strongly estrogenic cycles. With each item attacking estrogen at a different angle, side effects are often greatly reduced. The anti-estrogenic properties of Proviron are not unique to this compound. A number of steroids have in fact demonstrated similar activity. Dihydrotestosterone and Masteron (2methyl-dihydrotestosterone) for example have been successfully used as therapies for gynecomastia and breast cancer due to their strong anti-estrogenic effect. It has been suggested that nandrolone may even lower aromatase activity in peripheral tissues where it is more resistant to estrogen conversion (the most active site of nandrolone aromatization seems to be the liver). The anti-estrogenic effect of all of these compounds is presumably caused by their ability to compete with other substrates for binding to the aromatase enzyme. With the aromatase enzyme bound to the steroid, yet being unable to alter it, and inhibiting effect is achieved as it is temporarily blocked from interacting with other hormones. This drug is also favored by many during contest preparations, when a lower estrogen/high androgen level is particularly sought after. This is especially beneficial when anabolics like Winstrol, oxandrolone and Primobolan are being used alone, as the androgenic content of these drugs is relatively low. Proviron can supplement a well needed androgen, and bring about an increase in the hardness and density of the muscles. Women in particular find a single 25mg tablet will efficiently shift the androgen/estrogen ratio, and can have a great impact on the physique. Since this is such a strong androgen however, extreme caution should be taken with administration. Higher dosages clearly have the potential to cause virilization symptoms quite readily. For this reason females will rarely take more than one tablet per day, and limit the length of intake to no longer than four or five weeks. One tablet used in conjunction with 10 or 20mg of Nolvadex can be even more efficient for muscle hardening, creating an environment where the body is much more inclined to burn off extra body fat (especially in female trouble areas like the hips and thighs). The typical dosage for men is one to four 25 mg per tablets per day. This is a sufficient amount to prevent gynecomastia, the drug is often used throughout the entire cycle. As mentioned earlier, it is often combined with Nolvadex (tamoxifen citrate) or Clomid (clomiphene citrate) when heavily estrogenic steroids are being taken (Dianabol, testosterone etc.). Administering 50mg of Proviron and 20mg Nolvadex daily has proven extremely effective in such instances, and it is quite uncommon for higher dosages to be required. And just as we discussed for women, the androgenic nature of this compound is greatly welcome during contest preparation. Here again Proviron should noticeably benefit the hardness and density of the muscle, while at the same time increasing the tendency to burn off a greater amount of body fat. Proviron is usually well tolerated and side effects (men) are rare with dosages under 100 mg per day. Above this, one may develop an excessively high androgen level and encounter some problems. Typical androgenic side effects include oily skin, acne, body/facial hair growth and exacerbation of a male pattern baldness condition, and may occur even with the use of a moderate dosage. With the strong effect DHT has on the reproductive system, androgenic actions may also include an extreme heightening of male libido. And as discussed earlier, Women should be careful around Proviron. It is an androgen, and as such has the potential to produce virilization symptoms quite readily. This includes, of course, a deepening of the voice, menstrual irregularities, changes in skin texture and clitoral enlargement. Proviron is also not a c17 alpha alkylated compound, an alteration commonly used with oral anabolic/androgenic steroids. Not using this structure in the case of Proviron removes the notable risk of liver toxicity we normally associate with oral drugs. It is therefore considered a ?safe? oral, the user having no need to worry about serious complications with use. This steroid in fact utilizes the same 1-methylation we see present on Primobolan (methenolone), another well tolerated orally active compound. Alkylation at the one position also slows metabolism of the steroid during the first pass, although much less profoundly than 17 alpha alkylation. Likewise Proviron and Primobolan are resistant enough to breakdown to allow therapeutically beneficial blood levels to be achieved, although the overall bioavailability of these compounds is still much lower than methylated oral steroids. The popularity of Proviron amongst bodybuilders has been increasing in recent years. Many experienced bodybuilders have in fact come to swear by it, incorporating it effectively in most markedly estrogenic cycles. Due to high demand Proviron is now very easy to obtain on the black market. Most versions will be manufactured by Schering, and should cost about $1-$2 per 25 mg tab. This drug is packaged in both push-through strips and small glass vials, so do not let this alarm you. There is currently no need to worry about authenticity with this drug, as no counterfeits are known to exist. If money and availability does not prevent it, Arimidex, Femara, or Aromasin ares actually a much better choice than Proviron though. These drugs were designed specifically as an anti-aromatase, and works much more effectively than anything else we have available.
Please allow me to illustrate one of Provirons most pronounced effects ever, that somehow has failed to be discussed upon the masses.
Most of you that have ever took the breakfast of champions "Methandrostenolone", That's right, I'm talking about Dbol. What's the most apparent and conspicuous effects that takes place while taking Dbol? If you were about to say the "sense of well-being" than your correct. One of the most profound and desirable effects that we can have during a cycle..Now how about after a cycle? Or for longer durations? But we all know that many of us practice moderation with harsh orals,or I would hope, lol.
Well, one of the greatest characteristics about Proviron that has been shrouded and seldomly discussed is it's "Antidepressant" properties. With this being said, when it was first developed it was widely utilized in treatments for Bi-polar,OCD and Anxiety. As we know that depression is basically a chemical imbalance that comes about through the "Signaling" issues between receptors. Proviron improves the quality of the "channles" that the cells use to communicate and interact. Thus, a similar effect with Dbol where it drastically improves the sense of well being in users.
What I'm about to share is a double blind study that clearly shows undoubtedly astonishing results in the patients! An other great reason to consider this compound.
Why proviron is underestimated, the world may never know.. Thank you, Vision
A comparison of the antidepressant effects of a synthetic androgen (mesterolone) and amitriptyline in depressed men. Vogel, William; Klaiber, Edward L.; Broverman, Donald M. Journal of Clinical Psychiatry, Vol 46(1), Jan 1985, 6-8.
26 depressed male outpatients were randomly assigned to 14 wks of treatment with either mesterolone or amitriptyline in a double-blind parallel treatment design. Ss completed the Hamilton Rating Scale for Depression and a symptom checklist each week. Findings reveal that the drugs were equally effective in reducing depressive symptoms. Mesterolone produced significantly fewer adverse side effects than amitriptyline and did not produce hypomania or tachycardia, recognized side effects of amitriptyline. (10 ref) (PsycINFO Database Record (c) 2013 APA, all rights reserved)
Based on computer EEG (CEEG) profiles, in high doses, antidepressant properties of mesterolone, a synthetic androgen, were predicted. In a double-blind placebo controlled study, the clinical effects of 300-450 mg daily mesterolone were investigated in 52 relatively young (age range 26-53 years, mean 42.7 years) male depressed outpatients. During 6 weeks of mesterolone treatment, there was a significant improvement of depressive symptomatology. However, since an improvement was also established during the placebo treatment, no statistically appreciable difference in the therapeutic effects of mesterolone was established compared to placebo. Mesterolone treatment significantly decreased both plasma testosterone and protein bound testosterone levels. Patients with high testosterone levels prior to treatment seem to have had more benefit from mesterolone treatment than patients with low testosterone levels. The degree of improvement weakly correlated to the decrease of testosterone levels during mesterolone treatment.
Nice read. What would be harder on the hairline, proviron or masteron?
This is a question that has circulated the panels for years.. It basically comes down to your genetics and what you prone to per say. If one was to have more of a profound effect of hairloss ( being prone ) concerning the two compounds in comparison.. With my experience it would most deff be mast, displacing proviron into second place.. I seen guys shed like hell off of other compounds, and not this or that!
Each tablet contains 25 mg mesterolone.
-dihydro-testosterone, which is α-methyl compound of 5αMesterolone is the 1
considered to be the proper active androgen in many androgen-dependent target
Proviron is an oral androgen preparation which has only a slight central inhibitory
effect and, consequently, no restrictive effect on testicular function.
Proviron balances a deficiency of androgen formation which begins to fall gradually
with increasing age. Therefore, Proviron is suitable for the treatment of all conditions
caused by deficient endogenous androgen formation. In the recommended therapeutic
dosage, Proviron will not impair spermatogenesis. Proviron is especially well
tolerated by the liver.
PHARMACOKINETICS AND METABOLISM
Following oral ingestion mesterolome is rapidly and almost completely absorbed in a
wide dose range of 10 - 100 mg. The intake of Proviron generates maximum serum
drug levels of 3.1 ? 1.1 mg/ml after 1.6 ? 0.2 hours. Thereafter drug levels in serum
decrease with a terminal half-life of 12 13 hours. Mestorelone is bound to serum
proteins by 98%. Binding to albumin accounts for 40% and binding to SHBG to 58%.
Mestorelone is rapidly inactivated by metabolism. The metabolic clearance rate from
serum accounts for 4.4 ? 1.6 ml. min −1.kg−1 .
There is no renal excretion of unchanged drug. The main metabolite has been
identified as 1α - methyl-androsterone, which - in conjugated form - accounts for 55 -
70% of renally excreted metabolites. The ratio of main metabolite glucoronide to
sulphate was about 12:1. As a further metabolite 1α - methyl- 5α androstane-3α, 17β-
diol has been recognized, which accounted for about 3% of renally eliminated
metabolites. No metabolic conversion into estrogens or corticoids has been observed.
In form of metabolites mesterolone is excreted by about 85% of dose with the urine
and by about 14% of dose with the faeces. Within 7 days 93% of dose have been
recovered in excreta, the half of which had been excreted within 24 hours.
The absolute bioavailability of mesterolone was determined to about 3% of the oral
The daily intake of Proviron will lead to an about 30% increase in drug serum levels.
Androgen therapy in male patients only.
Reduced efficiency in middle and advanced age ?
Complaints attributable to androgen-deficiency, such as reduced efficiency,
easy fatigability, lack of concentration, weak memory, disturbances of libido and
potency, irritability, disturbances of sleep, depressive moods, and general vegetative
complaints, can be overcome or improved by the use of Proviron tablets.
Potency disturbances ?
Potency disorders based on an androgen deficiency are eliminated by
administration of Proviron. If other factors are the sole cause or if they contribute to
the disorders, Proviron may be administered in support of other therapeutic measures.
Growth, development and function of androgen-dependent target organs are
stimulated by Proviron. It promotes development of secondary male sex
characteristics in cases of prepuberal androgen-deficiency.
Proviron eliminates deficiency symptoms in cases where a loss of gonadal
function has occurred postpuberally.
Oligozoospermia and deficient Leydig-cell secretion may be the cause of
infertility. With Proviron, sperm count and sperm quality as well as the fructose
concentration in the ejaculate can be improved or normalized, thus increasing the
chances of procreation.
Previous or existing liver tumours.
Androgens are not suitable for enhancing muscular development in healthy
individuals or for increasing physical ability.
Risk of carcinoma ?
The occasionally expressed fear that prostatic carcinoma can be induced by
the use of androgens is unfounded. Androgens have no carcinogenic action.
Observations made over many years have shown that the risk of carcinoma in
men treated with androgens was no greater than in an untreated control group.
Specific studies of male patients under long-term and high-dosed therapy with
testosterone produced no signs of prostatic carcinoma and, hence, no evidence that the
exogenous supply of testosterone activates any atypical cells which may be present.
The regular check-ups during the therapy failed to reveal a single case of
carcinoma among patients with prostatic adenoma, whose complaints were favourably
influenced by Proviron.
Since androgens can exacerbate a clinically manifest carcinoma of the
prostate, malignant tumours of the prostate must be ruled out before the start of
Proviron treatment. As in prophylactic examinations of men, regular rectal and - if
required to confirm the diagnosis - biopsy examinations must be carried out during
Liver tumours ?
In rare cases, benign, and in even rarer cases, malignant liver tumours leading
in isolated cases to life-threatening intra-abdominal haemorrhage have been observed
after the use of hormonal substances such as the one contained in Proviron. A liver
tumour should be included in the differential-diagnostic considerations if severe upper
abdominal complaints, a liver enlargement or signs of an intra-abdominal
haemorrhage occur. If necessary, the preparation must be withdrawn.
Proviron is well tolerated even as regards liver function. Laboratory tests conducted
during high-dosed and long-term treatment produced no evidence for an injurious
effect. If, in individual cases, frequent or persistent erections occur, the dose should
be reduced or the treatment discontinued in order to avoid injury to the penis.
None recorded so far.
DOSAGE AND ADMINISTRATION
The tablets should be swallowed whole with some liquid.
The following dosages are recommended:
Reduced efficiency and potency disturbances: ?
Commencement of treatment:
1 Proviron tablet 3 times per day.
After satisfactory clinical improvement, it can be tried to reduce the dose.
Continuation of treatment:
1 Proviron tablet twice or once per day
According to the type and severity of the complaints, the dose for further
treatment is to be adjusted to individual requirements. Continuous treatment
over a period of several months is recommended.
Hypogonadism requires continuous therapy: ?
For development of secondary male sex characteristics, 1 - 2 Proviron tablets
3 times per day for several months.
As maintenance dose, 1 Proviron tablet 2 - 3 times per day will often be
Infertility - for the improvement of sperm quantity and quality: ?
1 Proviron tablet 2 - 3 times per day for a cycle of spermatogenesis, i.e. for
about 90 days. If necessary, Proviron treatment is to be repeated after an
interval of several weeks.
To achieve a higher fructose concentration in the ejaculate in cases of
postpuberal Leydig-cell insufficiency: 1 Proviron tablet twice per day over
Acute toxicity studies using single administration showed that Proviron is to be
classified as practically non-toxic. No risk of toxicity is to be expected even after
inadvertent single administration of a multiple of the dose required for therapy.