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Why peptides you use should be from a recombinant DNA source and not a (*MUST READ*)

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  1. #1
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    Exclamation Why peptides you use should be from a recombinant DNA source and not a (*MUST READ*)






    Why peptides you use should be from a recombinant DNA source and not a chemically synthesized source

    I want to bring something up about peptides and peptide quality. I see many people going the cheap route but there is a reason that they may be simply wasting their money. That is why I wanted to start a thread about an issue I think is going on related to efficacy of chemically synthesized IGF and most other peptides vs. recombinantly made ones.

    There are many threads on here about IGF-1 and other peps giving good gains and I feel some of it may be BS or the person is having a "placebo affect", while others swear peptides are a complete scam and do nothing at all! (not true)... There might be a reason your igf1 cycle didn't give you jack shit?

    Why? I believe most are purchasing IGF-1 (for an example of a popular peptide being used) made by cheap peptide synthesis companies. However, chemical synthesis of IGF-1 lacks the correct disulfide bonds that cause the proper folding and function in the peptide chain. IGF-1 and its many analogs require 3 disulfide bonds to generate the correct folded form of the protein and this can only be accomplished in the body as naturally produced, or in E.coli bacteria as a recombinant source which is similar to how HGH is made (recombinantly).

    Insulin is also very similar to the structure of IGF-1 and it also is inactive and/or unstable if synthesized chemically, it has to be made recombinantly or extracted from a biologic source (they used to extract insulin from bovine and HGH from cadavers).
    Made with "recombinant DNA" means it is made in bacteria which have data input into it and "fermented" create enzymes that make these intramolecular disulfide bonds so that the protein folds into the right configuration and has the biological function it is supposed to have, having the proper amino chain is NOT enough and it is NOT that simple!

    If you look into human clinical trials or current clinical treatment of patients, they now use some of these peptides as part of a therapy protocol and they use recombinant DNA made peptides, not chemically synthesized ones and for good reason.

    Here is just one of many studies on how important the correct bonds are, not just the structure>
    Role of native disulfide bonds in the structure... [Biochemistry. 1993] - PubMed - NCBI > Role of native disulfide bonds in the structure... [Biochemistry. 1993] - PubMed - NCBI


    There are many cheap peptide sellers popping out like CRAZY the last couple years with ridiculously low prices that just doesn't make any sense. So I say if it seems too good to be true, then it probably is!
    There is a reason some places are so cheap while others can cost more than 2X or 3X the amount of the cheaper places.

    You usually get what you pay for so PLEASE do your research first!

    Just because it's pricy doesn't automatically mean its top quality, you still need to research the company.
    But if it is really cheap then I would just avoid it because the chances of it being properly made are minimal in this case. IMO

    There is a flood of shotty quality peptides coming from china, BE SAFE AND AVOID!

    What you want is the more expensive recombinant DNA made peptides! NOT the cheaply made, unstable and largely biologically inactive chemically synthesized peptides!

    Many don't even have a clue about all this and that is why I am posting this thread.

    Hope it helps someone!


    Cheers



    PS. This rant came out of an argument I had today via PM about how Peptides are worthless and that I'm an idiot for thinking I got gains from them?.. Yeah, ok.... haha, not my fault you got crappy peptides more than once!! I hope you see this! I won't name names because I am a mature adult...
    Last edited by blergs.; 12-05-2013 at 12:18 PM.
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  2. #2
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    Thank you for the educational post. Information like this allows consumers to base their decisions on a level playing field. All our peptides are recombinant. We go this route to provide our customers with the highest quality product available for their research. Also we as a company feel it would be unethical to sell a research product manufactured in a way that would make it essentially useless once administered.
    Again thanks for posting such an educational thread for your fellow researchers! Good luck in your research!

  3. #3
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    I actually am a fan of cem's stuff


    "got her saved on my phone under big booty"

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    Quote Originally Posted by SheriV View Post
    I actually am a fan of cem's stuff
    I too use CEM and love the quality. They are one of only a couple places ill use for my peptides and RC's.
    LOVE the MT2 recently, will start it in spring again with maybe some igf1 ( got a few btls from last spring still)

    Anyway, my worry is MOSTLY with all the new places popping up all across the web these last 2 years, with super cheap prices that doesn't make any sense in relation to how much it should cost for "PROPER" production of the peptide and still have a margin for profit ( not like these places do it for free right lol)
    I just hope people see this and understand it is not just as simple as "having 95%+ purity and correct amino chain" There is much more to it, and these places are not necessarily lying in their advertising in many cases, just avoiding the truth IMO. they say "we got over 95% purity or 98% purity"... it may be very well true.. but is it stable and made in a high quality and biologically active fashion? that is a whole other story! and if its dirt cheap then likely not IMO.
    just piss's me off to see soo many ( I believe) getting ripped off, then swear off peptides altogether...
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    May have to give CEM a shot here soon. Great post brother

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    No doubt about it Peptide/Research Chemical companies are popping up like crazy. And you hit the nail on the head when clarifying the differences. Just because it says Peptide sure as hell does not mean what you're getting is the real deal or right deal. Thanks for spelling it out.

  7. #7
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    Thanks guys!
    Happy if it even helps one person take a step back and do further research on the place they plan to buy from to be extra safe and not piss away hard earned money.
    WHO I use and recommend for high quality products:


    An AWESOME Place for HARD CORE REAL Bodybuilding Supplements:


    Save an additional 15% with code: blergs15

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    Also save an extra 10% with code: blergs10

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    Excellent post! Now maybe people will realize you get what you pay for. The rc/pep industry is the same as the real world. Hopefully the days of dirt cheap useless igf and ghrp's etc are numbered if this becomes mainstream common knowledge.








  9. #9
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    Any other good pep sources? Never really tried PEPs and if it comes down to it...if I can't afford a good source I just won't. CEM is just a little too pricey with all my money being sunk into Christmas for family. Feel free to PM me if you don't want to post it openly.

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    Thanks for the info.

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