Yes, it can contribute. Anything that causes insulin resistance can contribute. the more insulin you use and the more frequently you use it, the quicker and more dramatically insulin resistance will build. there are some guys using over 250 IU daily, plus whatever their own body produces.
You see, with insulin, its effectiveness is not determined by dose, but rather, by your body's ability to use insulin. For example, if after 2 years of use you require less carbs at 50 IU than you did at 20 IU when you first started using insulin, then you are actually getting less benefit from the 50 IU than you were getting from 20 IU in the beginning. Obviously, if your blood sugar is going down less at 50 IU than it used to at 20 IU, then your body requires much more insulin to transport an equal amount of nutrients, which means it is now less effective per IU. The greater your insulin sensitivity, the more benefit you will get from a smaller amount, which means better metabolic health and ultimately, better results.