Prami Dose

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    Prami Dose

    how are you guys using Prami? .25 ed .50 ed or 1 mg ed. I have seen all of them but have no experience with it.

    I guess people start with low doses to get used to the sides. What do you guys think? How effective is prami at .25 or .50 against prolactin?
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    I found it to be 100% effective at 1.0 ED while running DECA @ 500mg per week. Side effects were being rock hard a lot! haha
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    any reason you chose prami over caber?

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    Quote Originally Posted by skinnyguy180 View Post
    how are you guys using Prami? .25 ed .50 ed or 1 mg ed. I have seen all of them but have no experience with it.

    I guess people start with low doses to get used to the sides. What do you guys think? How effective is prami at .25 or .50 against prolactin?
    Start with 0.1 mg daily and slowly work your way up to 0.5 mg daily

    Neuroendocrine and side effect profile of pramipexole, a new dopamine receptor agonist, in humans.

    Schilling JC, Adamus WS, Palluk R.

    Human Pharmacology Centre, Boehringer Ingelheim KG, Germany.

    The effects and tolerability of pramipexole, a new dopamine D2-receptor agonist, on prolactin, human growth hormone, thyrotropin, cortisol, and corticotropin levels were investigated in a randomized, double-blind, crossover study in 12 healthy volunteers. Single oral doses of 0.1, 0.2, and 0.3 mg pramipexole and placebo were studied over a period of 24 hours. Pramipexole decreased serum prolactin levels in a dose-dependent manner, with a maximum effect after 2 to 4 hours. Serum levels of human growth hormone were dose-dependently increased; however, this effect was only significant 2 hours after drug administration. Furthermore, a slight increase in serum cortisol levels and a slight decrease in serum thyrotropin levels was observed. Our findings show for the first time pharmacodynamic effects of pramipexole after single oral doses in healthy volunteers. The compound was well tolerated and showed an endocrine profile similar to other dopamine D2-agonists.
    PMID: 1350237 [PubMed - indexed for MEDLINE]

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    Quote Originally Posted by heavyiron View Post
    Start with 0.1 mg daily and slowly work your way up to 0.5 mg daily

    Neuroendocrine and side effect profile of pramipexole, a new dopamine receptor agonist, in humans.

    Schilling JC, Adamus WS, Palluk R.

    Human Pharmacology Centre, Boehringer Ingelheim KG, Germany.

    The effects and tolerability of pramipexole, a new dopamine D2-receptor agonist, on prolactin, human growth hormone, thyrotropin, cortisol, and corticotropin levels were investigated in a randomized, double-blind, crossover study in 12 healthy volunteers. Single oral doses of 0.1, 0.2, and 0.3 mg pramipexole and placebo were studied over a period of 24 hours. Pramipexole decreased serum prolactin levels in a dose-dependent manner, with a maximum effect after 2 to 4 hours. Serum levels of human growth hormone were dose-dependently increased; however, this effect was only significant 2 hours after drug administration. Furthermore, a slight increase in serum cortisol levels and a slight decrease in serum thyrotropin levels was observed. Our findings show for the first time pharmacodynamic effects of pramipexole after single oral doses in healthy volunteers. The compound was well tolerated and showed an endocrine profile similar to other dopamine D2-agonists.
    PMID: 1350237 [PubMed - indexed for MEDLINE]

    I got your advice on prami dosing before I took them, I started at .05mg and had to increase to 1.0mg. Is that an abnormally high dose?
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    start at .25 mg ed if you can. if I went up to .5 it would fuck me up. feel like death and usually end up puking
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    Almost every prami post talks about how sick they got from using prami, I guess I'm either lucky or my shit was under dosed, I dunno know
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    Quote Originally Posted by HFO3 View Post
    I got your advice on prami dosing before I took them, I started at .05mg and had to increase to 1.0mg. Is that an abnormally high dose?
    Some guys handle Prami well at 1 mg daily but man it can knock you on your ass if you increase dose too quickly.

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    at .25 mg it fucked me up
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    Of all things not to have side effects from it had to be fucken prami, why couldn't it have been tren
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    Quote Originally Posted by DaBeast25 View Post
    any reason you chose prami over caber?
    Price
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    Quote Originally Posted by DaBeast25 View Post
    any reason you chose prami over caber?
    Quote Originally Posted by tl0311 View Post
    Price
    That and availability.
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    Quote Originally Posted by heavyiron View Post
    Start with 0.1 mg daily and slowly work your way up to 0.5 mg daily

    Neuroendocrine and side effect profile of pramipexole, a new dopamine receptor agonist, in humans.

    Schilling JC, Adamus WS, Palluk R.

    Human Pharmacology Centre, Boehringer Ingelheim KG, Germany.

    The effects and tolerability of pramipexole, a new dopamine D2-receptor agonist, on prolactin, human growth hormone, thyrotropin, cortisol, and corticotropin levels were investigated in a randomized, double-blind, crossover study in 12 healthy volunteers. Single oral doses of 0.1, 0.2, and 0.3 mg pramipexole and placebo were studied over a period of 24 hours. Pramipexole decreased serum prolactin levels in a dose-dependent manner, with a maximum effect after 2 to 4 hours. Serum levels of human growth hormone were dose-dependently increased; however, this effect was only significant 2 hours after drug administration. Furthermore, a slight increase in serum cortisol levels and a slight decrease in serum thyrotropin levels was observed. Our findings show for the first time pharmacodynamic effects of pramipexole after single oral doses in healthy volunteers. The compound was well tolerated and showed an endocrine profile similar to other dopamine D2-agonists.
    PMID: 1350237 [PubMed - indexed for MEDLINE]

    Good info. I'm liking prami more now.
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    Start at .25mg/day fpr 7-10 days. Increase to .5mg/day. Many can stay at .5mg and it will do the job and then some. Prami is in my opinion the best choice provided you can tolerate it. It not only activates the d2 receptors , it activates d3 receptors significantly where as Caber and bromo do not. d3 receptor plays a key role in male sexual function. Prami is best suited for our purposes so long as you tolerate it. Starting at a low dose and working up helps this. Also take it with some food in your stomach.

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    Thank you for the responses guys.
    All characters appearing in this work are fictitious. Any resemblance to real persons, living or dead, is purely coincidental.

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