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Start with 0.1 mg daily and slowly work your way up to 0.5 mg dailyhow are you guys using Prami? .25 ed .50 ed or 1 mg ed. I have seen all of them but have no experience with it.
I guess people start with low doses to get used to the sides. What do you guys think? How effective is prami at .25 or .50 against prolactin?
Start with 0.1 mg daily and slowly work your way up to 0.5 mg daily
Neuroendocrine and side effect profile of pramipexole, a new dopamine receptor agonist, in humans.
Schilling JC, Adamus WS, Palluk R.
Human Pharmacology Centre, Boehringer Ingelheim KG, Germany.
The effects and tolerability of pramipexole, a new dopamine D2-receptor agonist, on prolactin, human growth hormone, thyrotropin, cortisol, and corticotropin levels were investigated in a randomized, double-blind, crossover study in 12 healthy volunteers. Single oral doses of 0.1, 0.2, and 0.3 mg pramipexole and placebo were studied over a period of 24 hours. Pramipexole decreased serum prolactin levels in a dose-dependent manner, with a maximum effect after 2 to 4 hours. Serum levels of human growth hormone were dose-dependently increased; however, this effect was only significant 2 hours after drug administration. Furthermore, a slight increase in serum cortisol levels and a slight decrease in serum thyrotropin levels was observed. Our findings show for the first time pharmacodynamic effects of pramipexole after single oral doses in healthy volunteers. The compound was well tolerated and showed an endocrine profile similar to other dopamine D2-agonists.
PMID: 1350237 [PubMed - indexed for MEDLINE]
Some guys handle Prami well at 1 mg daily but man it can knock you on your ass if you increase dose too quickly.I got your advice on prami dosing before I took them, I started at .05mg and had to increase to 1.0mg. Is that an abnormally high dose?
Priceany reason you chose prami over caber?
any reason you chose prami over caber?
Price
Start with 0.1 mg daily and slowly work your way up to 0.5 mg daily
Neuroendocrine and side effect profile of pramipexole, a new dopamine receptor agonist, in humans.
Schilling JC, Adamus WS, Palluk R.
Human Pharmacology Centre, Boehringer Ingelheim KG, Germany.
The effects and tolerability of pramipexole, a new dopamine D2-receptor agonist, on prolactin, human growth hormone, thyrotropin, cortisol, and corticotropin levels were investigated in a randomized, double-blind, crossover study in 12 healthy volunteers. Single oral doses of 0.1, 0.2, and 0.3 mg pramipexole and placebo were studied over a period of 24 hours. Pramipexole decreased serum prolactin levels in a dose-dependent manner, with a maximum effect after 2 to 4 hours. Serum levels of human growth hormone were dose-dependently increased; however, this effect was only significant 2 hours after drug administration. Furthermore, a slight increase in serum cortisol levels and a slight decrease in serum thyrotropin levels was observed. Our findings show for the first time pharmacodynamic effects of pramipexole after single oral doses in healthy volunteers. The compound was well tolerated and showed an endocrine profile similar to other dopamine D2-agonists.
PMID: 1350237 [PubMed - indexed for MEDLINE]
sounds awful.... I had no issues at all. well actually I slept like shit but I go through spouts of not sleeping. but I dont feel sick or tired. But I did just down a 22 ounce coffee with mct oil and butter. Which Im 99% sure is what pours out of the nipples of Jesus christ himself.... Yeah so i got that going for me.
i dont know how yall are talking dosing but i just get a drop on my mouth and i get so sick i would rather die stuff has to be posion. there is no way in hell you could take a dose even the smallest dose measurable and not want to die. i can not in words tell you how sick this stuff makes me. i think it has something to do with the suboxone i take idk.
Prami interrupts my sleep every time I use it.
Have you guys heard the theories on prolactin and Nor 19's? Supposedly there have been no verified cases of men lactating due to using such compounds like tren, deca, NPP. I used to always include caber in my cycles that included these preparations. This time I got my caber and prami on hand but decided to not use it unless I showed symptoms. Wouldnt you know it I am 7 weeks in on my Tren A cycle and no reported soreness or anything in regards to prolactin build up.
I still hit the Caber when I want to be a rock star in the bedroom but other than that I save my $$ for other things.
Your thoughts?
I know caber is not easy to get but I never felt any sides from it and man, ridiculous loads would be shot with it. Prami seems like a hassle to me when I can get caber easily but that is just me (used it with NPP).
You know I'm not exactly sure about the actual mechanism needed to start lactating. All I'm saying is I found I don't need caber or prami while on Nor 19's. Many other guys I've talked to say the same. Your right on the prolactin no one wants that building up. Estrogen is a different story. I found I make better gains when its present. I used to do a bunch or adex and letro but then after some research I cut it way back and for me I found better gains and my mood improved as well. Good points. I'm new here so still learning the pecking order. I appreciate your thoughts skinnyguy180.