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How bad is IGF-1 reduced by caber?

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    How bad is IGF-1 reduced by caber?

    I've read numerous sources discussing the IGF-1 reduction by taking caber. In the past on tren cycles I've used prami, and it's worked decent for preventing negative sexual sides. On the other hand at the dose I need to maintain libido (~1mg) it turns me into a zombie! This has always had me interested in trying caber, but the reduction in IGF-1 is not a good thing afaik. I'm also on HGH or IGF-1 LR3 most of the year...

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    I appreciate the question because I am curious what answers you will get. But if you are using IGF-1 Lr3 then wouldn't you be getting plenty of IGF-1 extrogeniously and not have anything to worry about?

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    I didn't think it did. I know(or I've heard nolva does). Never heard a thing about caber

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    It definitely lowers IGF-1 afaik. I will try and post some links to studies later when I get home. What I don't know is: does the IGF-1 LR3 "offset" this nonsense? Will IGF-1 LR3 still be worth running? Seems like an obscure question I suppose!

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    I dont have labs to prove this one way or the other but I've been on tren/caber/hgh/igf and tren/caber/hgh without igf.
    Whenever I take gh or igf and my igf levels are high I get very sleepy.I feel like a teenager through puberty sleeping 10-12 hours a day. I know is not scientific but I consistently have this happen to me.
    By adding or taking caber away nothing changed. I dont feel any difference untill I stop hgh or igf use.

    I know this is just bro science but I dont think it matter as long as you supplement hgh or igf. I could be wrong here but this is the best I can come up with without labs.

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    Vassille, thanks for the response. Maybe bro science but it's still very useful experience. Thanks for sharing. I wonder if the suppression of IGF-1 caused by caber is in the liver? If so that would make sense because by injecting exogenous IGF-1 we bypass the liver from my understanding? If all this is true then using some form if IGF-1 while running caber would be a good idea!

    I would love to run tren again but I cannot seem to keep a libido. Tried test high and test low. Tried proviron. Boner meds the only way to get an erection unfortunately. Or prami and that stuff makes me a zombie. Will try to run caber on my next tren run and do it with IGF-1!

    Anymore suggestions?

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    Quote Originally Posted by fenriswolf80 View Post
    Vassille, thanks for the response. Maybe bro science but it's still very useful experience. Thanks for sharing. I wonder if the suppression of IGF-1 caused by caber is in the liver? If so that would make sense because by injecting exogenous IGF-1 we bypass the liver from my understanding? If all this is true then using some form if IGF-1 while running caber would be a good idea!

    I would love to run tren again but I cannot seem to keep a libido. Tried test high and test low. Tried proviron. Boner meds the only way to get an erection unfortunately. Or prami and that stuff makes me a zombie. Will try to run caber on my next tren run and do it with IGF-1!

    Anymore suggestions?

    Your deduction makes sense, see how it works for you.
    This is a long shot but with tren try a small dose of T3 (12.5) and small dose masterone along with caber and IGF.
    So let's say cycle would look like this;

    8 week cycle

    400mg tren /week
    400mg prop/week OR (200mg test cyp and 200mg test prop per week)
    200mg mast/week
    1mg caber split 2x a week
    IGF (whatever protocol you want to use) one would be post workout like 40mcg.

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    J Clin Endocrinol Metab. 1998 Feb;83(2):374-8.
    Cabergoline in the treatment of acromegaly: a study in 64 patients.
    Abs R1, Verhelst J, Maiter D, Van Acker K, Nobels F, Coolens JL, Mahler C, Beckers A.
    Author information
    Abstract

    Cabergoline is a new, long acting, dopamine agonist that is more effective and better tolerated than bromocriptine in patients with hyperprolactinemia. Because dopamine agonists still have a place in the medical management of acromegaly, cabergoline might be a useful treatment. We, therefore, evaluated the effect of long term administration of cabergoline in a large group of unselected acromegalic patients. Sixty-four patients were included in a multicenter, prospective, open labeled study. A subgroup of 16 patients had GH-/PRL-cosecreting pituitary adenomas. Cabergoline was started at a dose of 1.0 mg/week and was gradually increased until normalization of plasma insulin-like growth factor I (IGF-I) levels, occurrence of unacceptable side-effects, or a maximal weekly dose of 3.5 mg (7.0 mg in 1 case) was reached. Treatment with cabergoline suppressed plasma IGF-I below 300 micrograms/L in 39% of cases and between 300-450 micrograms/L in another 28%. With pretreatment plasma IGF-I concentrations less than 750 micrograms/L, a suppression of IGF-I below 300 micrograms/L was obtained in 53% of cases, and a suppression between 300-450 micrograms/L was obtained in another 32%. By contrast, with pretreatment plasma IGF-I concentrations above 750 micrograms/L, only 17% of cases showed a suppression of IGF-I below 300 micrograms/L, and there was IGF-I suppression between 300-450 micrograms/L in another 21%. In GH-/PRL-cosecreting adenomas, 50% of cases suppressed plasma IGF-I levels below 300 micrograms/L, and another 31% did so between 300-450 micrograms/L, in contrast to only 35% and 27%, respectively in GH-secreting adenomas. Similar results were obtained concerning the secretion of GH. Tumor shrinkage was demonstrated in 13 of 21 patients, with a mass reduction by more than half in 5 GH-/PRL-cosecreting adenomas. Except for slight gastrointestinal discomfort and orthostatic hypotension in a few patients at the beginning of therapy, cabergoline treatment was well tolerated. Only 2 patients stopped medication because of nausea. The weekly dose of cabergoline ranged between 1.0-1.75 mg. A further increase in the dose was only effective in 1 GH-/PRL-cosecreting adenoma. The results of this study suggest that cabergoline is an effective, well tolerated therapy that should be considered in the management of acromegaly, especially if the pituitary adenoma cosecretes GH and PRL or if pretreatment plasma IGF-I levels are below 750 micrograms/L.

    PMID:
    9467544
    [PubMed - indexed for MEDLINE]

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    Can anyone suggest a good source for caber tabs?


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