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DAPOXETINE for Premature Ejaculation

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    Post DAPOXETINE for Premature Ejaculation






    DAPOXETINE is known to help prevent premature ejaculation.

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    Dapoxetine for premature ejaculation.


    Journal
    Drug Ther Bull. 2014 Mar;52(3):30-3. doi: 10.1136/dtb.2014.3.0240.


    ABSTRACT
    Premature ejaculation, also referred to as rapid or early ejaculation, is a poorly understood disorder with no single, widely-recognised, evidence-based definition. Studies based on patient self-reporting indicate that premature ejaculation is a common complaint with estimated prevalence ranging from 4%-39% of men in the general community.(1) However, a lack of an accurate validated definition has made comparison of the results of such studies difficult.(2) In addition, perception of normal ejaculatory latency varies by country and differs when assessed by the patient or their partner.(3) ▾Dapoxetine (Priligy-A. Menarini Farmaceutica Internazionale SRL), a short-acting selective serotonin reuptake inhibitor (SSRI) is the first drug to be licensed in the UK for on-demand management of diagnosed premature ejaculation.(4) In this article we review the evidence for dapoxetine and discuss some of the challenges associated with its introduction.
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    Nothing wrong with making your partner happy(ier) haha

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    Bump to become a porn star in the bedroom.
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    Might have to look at this one... been wondering when a drug to do this was going to come along....

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    Quote Originally Posted by crawfBigG View Post
    Might have to look at this one... been wondering when a drug to do this was going to come along....
    If you are interested in running a log on it I can give you BOGO pricing. Pm me if interested and I'll give you the BOGO CODE. You can use the code to get a BOGO deal
    on whatever you want with this purchase, no limit. Half off is our cost so it's well worth running a log.
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    30-60mg and you're a porn star in the bedroom.
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    I am gonna get this for my mate as he keeps asking me. I take a small dose of another SSRI for anxiety and that has the same effects. I have full control... could go on for 3 hours full force if I wanted to. Dapoxetine is prescribed by doctors for PE though as it's in and out of your system fairly quickly. Ideal for a special night in
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    DAPOXETINE TAKES ONE HOUR TO KICK IN AND LASTS UP TO 6 hours.
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    May have to look into this one too! That combined with some cialis sounds like a gift for the wife

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    Quote Originally Posted by Thornton View Post
    May have to look into this one too! That combined with some cialis sounds like a gift for the wife
    Hahaha just wrap a bow on it, and everyday is Christmaa!
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    Quote Originally Posted by Thornton View Post
    May have to look into this one too! That combined with some cialis sounds like a gift for the wife
    A gift for you too
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    Dapo will turn the 2 pump chump to a straight up porn star!! Gonna have to try this companys dapo to see how it stacks up

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    Quote Originally Posted by jayroc View Post
    Dapo will turn the 2 pump chump to a straight up porn star!! Gonna have to try this companys dapo to see how it stacks up
    Let us know how it goes
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    This study show it's safe to stack dapoxetine with tadalafil or sildenafil.


    Dapoxetine, a novel treatment for premature ejaculation, does not have pharmacokinetic interactions with phosphodiesterase-5 inhibitors.


    AuthorsDresser MJ, et al. Show all Journal
    Int J Impot Res. 2006 Jan-Feb;18(1):104-10.


    Affiliation
    Abstract
    Potential pharmacokinetic interactions between dapoxetine, a serotonin transporter inhibitor developed for the treatment of premature ejaculation (PE), and the phosphodiesterase-5 inhibitors tadalafil and sildenafil, agents used in the treatment of erectile dysfunction (ED), were investigated in an open-label, randomized, crossover study (n=24 men) comparing dapoxetine 60 mg, dapoxetine 60 mg+tadalafil 20 mg, and dapoxetine 60 mg+sildenafil 100 mg. Plasma concentrations of dapoxetine, tadalafil, and sildenafil were determined by liquid chromatography-tandem mass spectrometry. Tadalafil did not affect the pharmacokinetics of dapoxetine, whereas sildenafil increased the dapoxetine AUCinf by 22%; these effects were deemed not clinically important. Dapoxetine did not appear to affect the pharmacokinetics of tadalafil or sildenafil. Most adverse events were mild in nature. Thus, dapoxetine has no clinically important pharmacokinetic interactions with tadalafil or sildenafil, and the combinations are well tolerated.


    PMID 16307008 [PubMed - indexed for MEDLINE]
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    Dapoxetine lengthened normal ejaculation time by about 300% at a dose of 30mg taken one hour before intercourse, and about 400% at a dose of 60mg.
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    A benefit-risk assessment of dapoxetine in the treatment of premature ejaculation.


    AuthorsHutchinson K, et al. Show all Journal
    Drug Saf. 2012 May 1;35(5):359-72. doi: 10.2165/11598150-000000000-00000.


    Affiliation
    Abstract
    Premature ejaculation (PE) is considered to be the most common sexual problem affecting men, despite the likelihood that it is under-diagnosed. It is a complex condition with many physical and psychological components, making management complicated. It is important to develop treatments for PE as it adversely affects quality of life for individuals and partners. Dapoxetine is a short-acting selective serotonin reuptake inhibitor (SSRI) that has been developed principally for the treatment of PE. It is considered more suitable for the treatment of PE than other SSRIs as it can be used as an 'on demand' treatment to be taken a few hours before an expected sexual encounter, reducing the possibility of adverse effects. Dapoxetine may represent a breakthrough in the treatment of PE as it is the first drug to be licensed for this indication. This review attempts to present a balanced benefit-risk assessment of dapoxetine by examining the evidence from phase III clinical trials, focusing on its efficacy in prolonging intravaginal ejaculatory latency time (IELT), patient sexual satisfaction and safety in patients with PE. The benefits and risks of other therapies that are used to treat PE off-licence are also reviewed. There has only been one study to date that directly compares dapoxetine to another therapy, paroxetine, for this indication. It was found that dapoxetine is most effective at a dose of 60 mg in increasing IELT compared with placebo. All studies have also found that dapoxetine is well tolerated as an 'on-demand' therapy and with continual dosing; however, there are little data regarding possible long-term adverse effects. Findings of the dapoxetine development programme demonstrated that dapoxetine is associated with vasovagal-mediated (neurocardiogenic) syncope. No other associated significant cardiovascular adverse events were identified. Further research is needed to directly compare dapoxetine with other therapies and to investigate the outcomes of dapoxetine used in conjunction with behavioural therapies, and other non-pharmaceutical therapies.
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    Dapoxetine appears to improve personal distress and interpersonal difficulties associated with premature ejaculation

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    An overview of pharmacotherapy in premature ejaculation.


    Authors
    Porst H.
    Journal
    J Sex Med. 2011 Oct;8 Suppl 4:335-41. doi: 10.1111/j.1743-6109.2011.02451.x.


    Affiliation
    Abstract
    INTRODUCTION: With increasing interest and clinical research in male sexual disorders, it has become clear that not only psychological but also organic, neurobiological, and genetic factors may play an important role in premature ejaculation (PE).


    AIM: This article provides an overview of the different treatment options both for lifelong (primary, "congenital") and acquired (secondary) PE.


    METHODS: Review of the literature.


    MAIN OUTCOME MEASURES: Currently used treatment options for PE.


    RESULTS: Treatments reviewed include psychological/behavioral/sexual counseling therapy, topical anesthetics, dapoxetine, and other selective serotonin reuptake inhibitors (SSRIs), tricyclic antidepressants, and phosphodiesterase-5 (PDE-5) inhibitors.


    CONCLUSIONS: Before starting any therapy for PE, correct diagnosis has to be made considering the patient's reported intravaginal ejaculatory latency time (IELT) and the duration and type of PE. Concomitant erectile dysfunction (ED) should be either ruled out or proven by appropriate means. In uncomplicated cases of PE with stable partnerships, medical treatment represents the first-choice option with a high likelihood of success. Dapoxetine, where available, or other SSRIs provide suitable therapeutic options with a good risk/benefit profile for patients. In complicated ("difficult-to-treat") PE patients, a combination of medication and sexual counseling should be considered the first treatment option. Combination therapies of PDE-5 inhibitors and PE-related medications should be offered to patients suffering from comorbid PE and ED, with ED treatment starting first. In those patients with severe PE-IELTs of <30-60 seconds or anteportal ejaculation-combination therapy of topical and oral medications can be offered and may considerably increase IELT, compared with either monotherapy.
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    Post from another forum....


    "I've used this a few times, if you need to absolutely punish her, dapox is perfect!"
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    Here is a post from a SuperiorPeptide customer at another forum:


    "Used it last night and all I can say it wow. The stuff definitely works. Made me last a hell of a lot longer than I thought it would, which helped with confidence. Went at it a couple times last night and a couple times this morning. All I did was take one dose of 30mg then 5mg about 5 hours later, don't know why. I felt like it even worked this morning, either that, just the confidence boost itself helped that much. Great product!"
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    This is a post from a Superior customer on another forum regarding Superior dapoxetine:


    "I just wish I knew about this stuff before I slept with her the first time. Lol. I think I've redeemed myself."
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    With Dapoxetine, you can focus on enjoying better sex instead of being distracted by trying to hold back long enough to satisfy your partner.
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    Post from another forum...




    "Met a very fun and open minded girl, took a 10mg dose of Cialis and a 30mg dose of Dapoxetine before sex, this time instead of having to slow down and risk losing my erection, I was able to just keep going, and going, and going. It was the first time in about 7 or 8 years that I've really been able to knock a woman's socks off sexually."
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    i have tried this from 2 diff company not working for me.do you think there stuff was just bunk or under dosed or it just dont work for me.i would like to try some of yours but dont want to waste my money if it is not going to work but if yours worked and others did not that would look good on yall for sure.all so does yall stuff taste really bad what i have taste like acid.

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    where can we buy this stuff?

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    Quote Originally Posted by Patmuscle View Post
    where can we buy this stuff?
    Just click on our banners and use the code MBOGOF to get buy one get one free. So add 2 bottles of dapoxetine and apply the code and you pay for only one. Not long to go on the BOGO promo though.
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    i bought some of yalls dapo. others have not worked well for me hoping yalls does. do you know if it taste really bad most do.i all so got some t3 this will be my first time with this company so we will see how they compare because i have used lots of pep company so we will see.

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    Quote Originally Posted by BIGBEN2011 View Post
    i bought some of yalls dapo. others have not worked well for me hoping yalls does. do you know if it taste really bad most do.i all so got some t3 this will be my first time with this company so we will see how they compare because i have used lots of pep company so we will see.
    Good stuff. Let us know how you get on with your items I imagine it will taste like crap but it will be worth it!
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    man it taste like shit why does it have to taste so bad i can handle something tasting bad but this burns your mouth like acid or something and it last for 30- or a hr where you can not taste nothing and you sure and hell can not have sex all you can think about is how you might die from the burning it is bad but other company i have used where worse and i will say this company does work i have to take a lot of it to work for me.like 60- 90 mg which means three full squirts the only way i can take it is with oj to chase it like i say it is not just oh this taste bad it is like drinking acid.they really need to add something to help cover the taste and the burn that just last forever.but besides that it works well and there shipping was super fast and everything was good and with the bogo you can not beat the price.i am saying all good things about this shop it just the dapo just taste bad thats all.

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