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Melanotan 2 for summer

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    Melanotan 2 for summer

    Melanotan II

    Melanotan 2 (MT2) is a synthetic cyclic heptapeptide that is mainly used to increase tanning. It stimulates a natural increase in melanin production. Melanin is the main determinant of skin color in humans. Melanin is a brown pigment which causes skin to become darker in appearance when exposed to UV rays.

    Melanotan II was first synthesized at the University of Arizona when looking at possible ways to treat skin cancer. They hypothesized that an effective way to reduce skin cancer rates in people would be to induce the body's natural pigmentary system to produce a protective tan prior to UV exposure.

    Clinical trials have shown that Melanotan 2 safely promotes melanogenesis. This is a process were melanocytes produce melanin. Lighter-skinned people have low base levels of melanogenesis. Exposure to UV-B radiation causes an increased melanogenesis. The purpose of the melanogenesis is to protect the hypodermis, the layer under the skin, from the UV-B light that can damage it. It does this by absorbing all the UV-B light and blocking it from passing the skin layer.

    I have conducted my own research on the tanning effects of MT2. My own clinical trials have displayed the fast and pronounced effects MT2 has on promoting melanogenesis. MT2 is a very powerful drug in this regard and results have been seen with as alittle as 100mcg daily injected subcutaneously. Results increased in a dose dependent manner during my experiments. However side effects were seen in my testers at higher dosages. As a result I feel the optimal dosing range for future clinical trials would be 250-500mcg daily.

    MT2 has also been shown to have aphrodisiac effects. Giuliano F et al. (2006) showed MT2 exerting a dose-dependent effect on erections in anesthetized rats. They went on to show MT2 having inducer and facilitator activities on erection depending upon delivery route of the peptide. There are various studies showing similar results in both animals and humans. Wessells H et al. (2000) highlighted the positive effect MT2 has on sexual desire and erections in men suffering with erectile dysfunction and various organic risk factors.

    Through clinical research it has been shown MT2 has excellent fat burning effects. It was previously thought that it assisted weight loss indirectly due to its appetite-reducing effect. However, it now appears that MT2 has direct fat burning effects. Strader AD et al. (2007) is a great example of the direct fat burning effect. They conducted a series of tests including one that shown MT2 treatment led to a general reduction in both visceral and subcutaneous fat tissue in high-fat-fed mice. Choi YH et al. (2003) also showed in addition to reducing food intake and inhibiting body weight gain, administration of MT2 reduces fat mass. They concluded this was most likely by accelerated lipid mobilization, but not by apoptosis (cell death).

    A very interesting effect MT2 brings about is it's ability to increase insulin sensitivity during researchers trials. Heijboer AC et al (2005) studied the effects MT2 has on hepatic and whole-body insulin sensitivity. Results showed administration of MT2 increased insulin-mediated glucose disposal but did not affect the capacity of insulin to suppress EGP. MT2's acute effect on insulin sensitivity was further highlighted during studies done by the Nagoya University Graduate School of Medicine. Banno R et al. (2007) examined the effects MT2 had on insulin sensitivity in diet-induced obese rats. The insulin tolerance test showed that insulin sensitivity was significantly improved in the MT2 group compared to the pair-fed group. Furthermore, MT2 treatment increased the number of small-sized adipocytes in epididymal white adipose tissues, suggesting that MT2 increased insulin sensitivity through action on the white adipose tissues.

    Side effects are usually observed when MT2 is researched. The most common noticed usually in the early stages of clinical trials are:
    Nausea and decreased appetite, flushing of the face, tiredness and yawning, spontaneous erections (males).
    These should disappear over a short space of time. Although I recommend bed time dosing to minimize certain side effects. An anti histamine is very useful 1 hour before injection. Ginger root is a natural anti-histamine and anti-emetic so is great for this purpose.

    Less common side effects during longer trials include:
    Darkening of lips, darkening of freckles, increased libido (females).
    If you wanted to minimize these effects I would recommend using a lower dose. For the darkening of lips a high strength sun block should be used as a preventative measure.

    References

    1. Giuliano F, Clément P, Droupy S, Alexandre L, Bernabé J (2006) Melanotan-II: Investigation of the inducer and facilitator effects on penile erection in anaesthetized rat. PMID: 16360286 [PubMed - indexed for MEDLINE]
    2. Choi YH, Li C, Hartzell DL, Lin J, Della-Fera MA, Baile CA (2003) MTII administered peripherally reduces fat without invoking apoptosis in rats. PMID: 12834806 [PubMed - indexed for MEDLINE]
    3. Strader AD, Shi H, Ogawa R, Seeley RJ, Reizes O (2007) The effects of the melanocortin agonist (MT-II) on subcutaneous and visceral adipose tissue in rodents. PMID: 17567964 [PubMed - indexed for MEDLINE]
    4. Banno R, Arima H, Hayashi M, Goto M, Watanabe M, Sato I, Ozaki N, Nagasaki H, Ozaki N, Oiso Y (2007) Central administration of melanocortin agonist increased insulin sensitivity in diet-induced obese rats. PMID: 17321524 [PubMed - indexed for MEDLINE]
    5. Heijboer AC, van den Hoek AM, Pijl H, Voshol PJ, Havekes LM, Romijn JA, Corssmit EP (2005) Intracerebroventricular administration of melanotan II increases insulin sensitivity of glucose disposal in mice. PMID: 15971058 [PubMed - indexed for MEDLINE]
    6. Wessells H, Gralnek D, Dorr R, Hruby VJ, Hadley ME, Levine N (2000) Effect of an alpha-melanocyte stimulating hormone analog on penile erection and sexual desire in men with organic erectile dysfunction. PMID: 11018622 [PubMed - indexed for MEDLINE].
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    When I start MT2 I start with as little as 50mcg. The way I look at it is it means no horrible nausea etc. Even 100mcg can bring about a dark tan. I would stay around 100mcg for at least a week. Then slowly move up to a max of about 250-400mcg. 250mcg will give you a dark tan and if you move up slowly side effects should be minimal. Obviously the higher you go the darker you go but the chances of side effects increase. No one needs to be injecting 1mg... throwing away money.
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    Bump for anyone interested
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    yes people are really wrong about how potent this stuff is if i high dose it yes i get dark fast like black person dark but i look like shit. but if i super low dose it i can look great yes it takes longer but it is still fast.i take .5 -100mcg maybe 3 or 4 days a week and only lay in tanning bed 1 week for like 15mins.i am super dark.a vial last forever and after a couple vials and you get super dark you stay dark for months and months after you stop taking it.all so it makes you a porn star or better really and it cutts you up stuff is great.

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    Quote Originally Posted by BIGBEN2011 View Post
    yes people are really wrong about how potent this stuff is if i high dose it yes i get dark fast like black person dark but i look like shit. but if i super low dose it i can look great yes it takes longer but it is still fast.i take .5 -100mcg maybe 3 or 4 days a week and only lay in tanning bed 1 week for like 15mins.i am super dark.a vial last forever and after a couple vials and you get super dark you stay dark for months and months after you stop taking it.all so it makes you a porn star or better really and it cutts you up stuff is great.
    Good stuff Yeah smaller doses are best and gradually getting darker as opposed to blasting this stuff. I use 100-250mcg ed. If I go on a sunbed I only stay on for 6-9mins.
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    I get massive erections from melanotan2. When I also use tadalafil it feels like my dick is going to explode!!!
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    100-250 ed is to much i think like i say maybe 300mcg a week or so you dont have to take it ed 100mcg a couple times a week is plenty for me.and yes the erection part is all most to much for me. test,mt2 and cialis will make her jaw and her panties drop to the floor.

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    Quote Originally Posted by BIGBEN2011 View Post
    100-250 ed is to much i think like i say maybe 300mcg a week or so you dont have to take it ed 100mcg a couple times a week is plenty for me.and yes the erection part is all most to much for me. test,mt2 and cialis will make her jaw and her panties drop to the floor.
    That why I take it ed haha Barbie needs to be pleased. JJ no one knows Barbie on here... might have to post a pic
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    On mt2 now and had a sunbed today and starting to go dark which is good
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    I've read that you should load this for ten days, then only once or twice a week to maintain. How true is this? I'm a brown person, only looking for a slight tan, was thinking 100mcg for 10 days, then 100mcg a week to maintain. Does that sound about right?

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    Quote Originally Posted by rambo99 View Post
    I've read that you should load this for ten days, then only once or twice a week to maintain. How true is this? I'm a brown person, only looking for a slight tan, was thinking 100mcg for 10 days, then 100mcg a week to maintain. Does that sound about right?

    Sent from my SGH-M919 using Tapatalk
    Please do not load mt2. Start at 100mcg per day and gradually move up to 250mcg per day. Do this for a few weeks. Then maintain on 100-250mcg twice weekly. Let me know how you get on with it
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    I don't want to get super tan that's why I wanted to stay at 100mcg a day, will that not work well?

    Sent from my SGH-M919 using Tapatalk

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    Where can you get it

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    Quote Originally Posted by Elvia1023 View Post
    Please do not load mt2. Start at 100mcg per day and gradually move up to 250mcg per day. Do this for a few weeks. Then maintain on 100-250mcg twice weekly. Let me know how you get on with it

    Why do you recommend this over other protocols?

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    Quote Originally Posted by OfficerFarva View Post
    Why do you recommend this over other protocols?
    Id like to know the same

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    Quote Originally Posted by rambo99 View Post
    I don't want to get super tan that's why I wanted to stay at 100mcg a day, will that not work well?

    Sent from my SGH-M919 using Tapatalk
    Sorry... yes 100mcg is more than enough. Just do it ed till you get to the colour you want. I would carry on for a few days extra (ed) then start maintenance of 100mcg twice weekly.

    Quote Originally Posted by AvA182 View Post
    Where can you get it
    The company I work for sells it. We have just started a BOGO promo tonight so just click on my banner and use the code if you want.

    Quote Originally Posted by OfficerFarva View Post
    Why do you recommend this over other protocols?
    I recommend different protocols. But this is the best one for results with minimum side effects. Many protocols are based on weight and that is nonsense. MT2 when used at say 500mcg for the first time can cause severe nausea. By doing this you're just ensuring you minimize any risk of basically feeling like crap. It will work just as good. Moreover it is cheaper doing it this way. Additionally sometimes when guys take too much (1mg and over ed) they can go a weird colour and the possibility of new moles and freckles is increased. Moles and freckles are always a possibility but by gradually moving up slowly you are helping your chances. The way I look at it you just wait another week for it to build up. Plus you want to have it build up slowly in your system. I have gone super dark from as little as 100mcg per day. But I think 250mcg is more than enough for most. At my highest I will do 250mcg twice daily if I want to basically change race!
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    Someone mentioned to me about it making their flaccid penis bigger so I will put my reply in here... MT2 has been shown to increase erection ability and quality in numerous studies. By reason of the pathways it works within I would say a larger flaccid penis is highly probable. That's a common side effect with most drugs that help with erection (cialis etc). If it gives better erections it would make sense better blood flow etc so a bigger flaccid penis. Check the study below it gave 17/20 men with ED problems an erection with one dose (and no sexual stimulation)!

    Melanocortin receptor agonists, penile erect... [Int J Impot Res. 2000] - PubMed - NCBI
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    Here is another study (this time on rats) were it improves glucose tolerance and increases slin sensitivity

    The melanocortin agonist melanotan II increases ins... [Peptides. 2004] - PubMed - NCBI
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    Quote Originally Posted by Elvia1023 View Post
    Here is another study (this time on rats) were it improves glucose tolerance and increases slin sensitivity

    The melanocortin agonist melanotan II increases ins... [Peptides. 2004] - PubMed - NCBI

    I'm honestly trying to get a long evans rat to have as a pet. I've done some research on them and sent them to the mini rat guillotine lol.

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    I just started mt2 today for the first time. We will see how it goes. I started today at 500mcg but after reading some more I may drop it down a little bit and see what happens.. From what I understand it works best when you hop in the tanning bed a couple times a week. Got mine from elitepeptides.com
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    Quote Originally Posted by Elvia1023 View Post
    Someone mentioned to me about it making their flaccid penis bigger so I will put my reply in here... MT2 has been shown to increase erection ability and quality in numerous studies. By reason of the pathways it works within I would say a larger flaccid penis is highly probable. That's a common side effect with most drugs that help with erection (cialis etc). If it gives better erections it would make sense better blood flow etc so a bigger flaccid penis. Check the study below it gave 17/20 men with ED problems an erection with one dose (and no sexual stimulation)!

    Melanocortin receptor agonists, penile erect... [Int J Impot Res. 2000] - PubMed - NCBI
    That's wild. The test group was basically given 2.5mg's (2,500mcg), to receive those results. That's 1/5th of a 10mg vial. I might want to order a case of these! Lol

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    Quote Originally Posted by SuperLift View Post
    I just started mt2 today for the first time. We will see how it goes. I started today at 500mcg but after reading some more I may drop it down a little bit and see what happens.. From what I understand it works best when you hop in the tanning bed a couple times a week. Got mine from elitepeptides.com
    SuperLift, keep us posted, I'm interested to hear your results and progress, thanks Riles

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    Quote Originally Posted by Riles View Post
    SuperLift, keep us posted, I'm interested to hear your results and progress, thanks Riles
    Will do! Today is only day 5 I believe, so I haven't noticed to much yet.. More frequent erections but that's about it. Not a bad side effect! Haha
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    Quote Originally Posted by SuperLift View Post
    Will do! Today is only day 5 I believe, so I haven't noticed to much yet.. More frequent erections but that's about it. Not a bad side effect! Haha
    500mcg should make you feel ill first time. I took 100mcg Superior's MT2 the other night and could feel it big time. I have took up to 1mg per night before so no stranger to high doses. Over the years I have found the higher post inj flush and nausea usually equates to better tanning abilities later in a cycle. On the purest stuff I go so red post inj it looks weird... like a tomatoe. 250mcg is more than enough for fantastic results so I would half your dose to that for now. Don't go on a sunbed for now and let it build up in your system more before you do. Good luck with your cycle
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    So I've been running 80mg/day of accutane and just started using mt2 @ around 300mg/day. I went in the booth once for 8 minutes, burnt pretty good, but holy fuck I'm brown already. Tomorrow I'll go for 6 minutes but damn, this is unreal.

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    Since this has to be refrigerated, I'm assuming it comes in solid form and you have to add bacteriostatic water? Farva, please keep posting your results, you're one of the guys I trust around here.

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    Quote Originally Posted by OfficerFarva View Post
    So I've been running 80mg/day of accutane and just started using mt2 @ around 300mg/day. I went in the booth once for 8 minutes, burnt pretty good, but holy fuck I'm brown already. Tomorrow I'll go for 6 minutes but damn, this is unreal.
    I wouldn't go on sunbed straightaway. Once it builds up you shouldn't burn at all. Please don't go on 2 sun beds in 2 days.. too much. Wait 4 days or so and go on for 6 mins. Little and fairly often is best for now.

    Quote Originally Posted by G3 View Post
    Since this has to be refrigerated, I'm assuming it comes in solid form and you have to add bacteriostatic water? Farva, please keep posting your results, you're one of the guys I trust around here.
    MT2 shouldn't be about trust as there are 1000's of detailed threads about it all over the net. Yes you add in bac water...3ml is best for a 1st vial.
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    I have used superiors MT2 a few times at 100mcg and it is super strong. Even at that dose I get flushed and nauseous and I was taking another brand before this. I have got darker in the last few days but no sun exposure. I will let it build up for a few more days then go on a 6 min sunbed on the w/e
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    I love MT2. I go tanning everyday for 5 days, then go 1 or 2 times a week. I get incredibly dark in the first two weeks. Most think I lived on a beach for 3 months in the dead of winter here because of MT2.
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    how many mL's bac water do people usually use for the 10mg melanotan ?

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