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Thread: Selank

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    Selank

    Selank Benefits:


    Reduced Level Of Emotional Tension, Anxiety and Fear


    Optimizes The Higher Cortical Functions Of The Brain (Speech, Thought, Movement Coordination)


    Improves Memory (Storing, Processing / Structuring, Recalling)


    Improves Focus & Concentration, (i.e. Student Exams, Long Work Hours)


    Reduces Mental Fatigue


    Improves Stress Tolerance


    Elevates & Stabilizes Mood


    Improves Sleep Quality


    Improve Physical & Mental Function


    Enhances Immune System


    PLUS


    NO Significant Side Effects


    NO Allergic Reactions


    NO Interactions With Other Drugs


    NO Addiction Or Withdrawal


    NO Motor Skill Impairment
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    From what I've found on other sites, the best dosing protocol for Selank is subQ injection of 250 mcg twice a day.
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    I have read a lot about selank in the last year and it sounds like it would be incredible for general/social anxiety and stress in general
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    SELANK FOR DEPRESSION




    [Effects of heptapeptide selank on genetically-based and situation-provoked symptoms of depression in behavior in WAG/Rij and Wistar rats, and in BALB/c mice].


    AuthorsSarkisova KIu, et al. Show all Journal
    Zh Vyssh Nerv Deiat Im I P Pavlova. 2008 Mar-Apr;58(2):226-37. Article in Russian.


    Affiliation
    Abstract
    A synthetic derivative of the endogenous peptide tuftsin heptapeptide selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro) possesses an anxiolytic and psychostimulant effect, and represents a working element of a new peptide drug having completed the third phase of the clinical testing as a selective anxiolytic. The neurobiochemical spectrum of selank action combines mechanisms which are characteristics of antidepressants and psychostimulants: activation of the brain monoaminergic systems, dopamine synthesis and turnover, and modulation of the tyrosine hydroxylase activity. The aim of this study was to investigate the effect of selank in a new model of inherited (genetically-based) symptoms of depression in behavior of inbred WAG/Rij rats in comparison with its effect on situation-provoked symptoms of depression in behavior of BALB/c mice. Outbred Wistar rats constituted control group. Selank in high doses (1000-2000 microg/kg), after repeated injection counteracted symptoms of depression in behavior of WAG/Rij rats (increased immobilization in the forced swimming test and decreased sucrose intake or preference (anhedonia)). Selank in low doses (100 and 300 microg/kg) after single injection reduced the duration of immobility of BALB/c mice in the forced swimming test, but did not exert significant effect after repeated injection or after injection in high doses (600 and 900 microg/kg). Selank did not affect the level of general locomotor activity and anxiety in WAG/Rij rats, and did not exert substantial effect on the behavior of control Wistar rats. The results demonstrate the presence of antidepressant component in the spectrum of neuropsychotrophyc activity of selank and indicate the higher reliability of a new experimental model of depression (the WAG/Rij rats) as compared to the standard forced swimming test for the determination of antidepressant activity of a pharmacological drug
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    This medical study shows Selank has applications in anti viral medicine with regards to the flu. Wish I had this last week.


    [Antiviral activity of immunomodulator Selank in experimental influenza infection].


    AuthorsErshov FI, et al. Show all Journal
    Vopr Virusol. 2009 Sep-Oct;54(5):19-24. Article in Russian.


    Affiliation
    Abstract
    The main objective of this study was to evaluate the antiviral properties of the glyproline Selank in both in vitro and in vivo against the influenza virus strain A/Aichi 2/68 (H3N2). The pronounced antiviral effect of the agent was detected in both systems. Selank added to the cell culture 24 hours before inoculation (a preventive use scheme) showed the highest efficiency, by completely suppressing viral reproduction. The in vivo studies also demonstrated that the highest survival of laboratory animals was observed when the agent was administered by the prevention scheme. The use of Selank in vivo induced the gene expression of interferon-alpha (IFN-alpha), without affecting that of interleukin (IL)-4, IL-10, or tumor necrosis factor-alpha (TNF-alpha). The findings suggest that the mechanism of the antiviral action of Selank may be due to its ability to modulate Th1/Th2/Treg cytokine equilibrium both directly and indirectly via the central nervous system. This is particularly promising if that the agent is synthesized on the basis of an endogenous peptide and that it has no negative effects is kept in mind.


    PMID 19882898 [PubMed - indexed for MEDLINE]
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    Selank regulates inflammation invivo.


    Expression of inflammation-related genes in mouse spleen under tuftsin analog Selank.


    AuthorsKolomin T, et al. Show all Journal
    Regul Pept. 2011 Oct 10;170(1-3):18-23. doi: 10.1016/j.regpep.2011.05.001. Epub 2011 May 24.


    Affiliation
    [B]Abstract/B]
    Previous studies have shown that synthetic tuftsin analogue Selank causes a transcriptomic response in the rat hippocampus and in spleen cells and may participate in the regulation of inflammatory processes in the body. In this work we studied the effect of Selank and two of its fragments on the expression of genes involved in processes of inflammation. We analyzed the expression of 84 genes involved in processes of inflammation (e.g., chemokines, cytokines, and its receptors) in mouse spleen 6 and 24 h after Selank single intraperitoneal injection (100 μg/kg) using real-time PCR method. We found significant changes in the expression of 34 genes involved in inflammation processes. The detailed analysis of quantitative data showed that the Bcl6 gene, which plays a main role in the formation and development of the immune system, exhibited significant changes in its expression levels in response to injection of each of the peptides. Also, we observed expression changes for Bcl6 target and corepressor genes under the influence of Selank and its fragments. Our results showed that Selank and its fragments caused a number of alterations in the expression of genes involved in inflammation. The data obtained confirmed the participation of Selank in the processes of regulation of inflammation in the body. The complex biological effect of Selank may be partially determined by the systematic effect of this peptide on genomic expression.
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    In clinical trials, the drug has shown to provide a sustained nootropic and anxiolytic effect, which is useful for the treatment of generalized anxiety disorder (GAD).[1] Selank has an advantage over traditional anxiety treatments, such as benzodiazepines, as it has no sedating or cognitive side effects and no associated addiction or withdrawal syndrome. Selank also has very low toxicity with an overdose proving harmless even up to 500 times the effective dose. When released, the drug will be used as a 0.15% aqueous solution which is applied to the nasal mucosa in drops. It is thought that this is the best method for absorbing peptide based drugs. The drug can be used to suppress feelings of fear and anxiety in people with anxiety disorders and to stimulate learning and memory in healthy people.
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    In clinical trials, the drug has shown to provide a sustained nootropic and anxiolytic effect, which is useful for the treatment of generalized anxiety disorder (GAD).[1] Selank has an advantage over traditional anxiety treatments, such as benzodiazepines, as it has no sedating or cognitive side effects and no associated addiction or withdrawal syndrome. Selank also has very low toxicity with an overdose proving harmless even up to 500 times the effective dose. When released, the drug will be used as a 0.15% aqueous solution which is applied to the nasal mucosa in drops. It is thought that this is the best method for absorbing peptide based drugs. The drug can be used to suppress feelings of fear and anxiety in people with anxiety disorders and to stimulate learning and memory in healthy people.
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    Selanks’ method of action is entirely unique of most other nootropics. It is thought to modulate the concentration of monoamine neurotransmitters. This may have incredible benefits for cognition. Another recognized benefit is its alleged effects on brain-derived neurotropic factor (BDNF)
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    Selank is able to influence the release of both the neurotransmitter Dopamine and Serotonin.
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    Selank considered to be immunomodulatory, or capable of improving and changing the immune system for the better.
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    [Compensatory and antiamnestic effects of heptapeptide Selank in monkeys].

    Authors
    [No authors listed]
    Journal
    Zh Evol Biokhim Fiziol. 2008 May-Jun;44(3):284-90. Article in Russian.

    Affiliation
    Abstract
    The work presents results of study of role of heptapeptide Selank--an anxiolytic from group of biologically active peptides--in compensation of disturbed psychic and homeostatic functions in monkeys. New data have been obtained which indicate that an intranasal administration of Selank produces long-term changes of the monkeys' behavior disturbed during neurosis: elimination of fear and aggression and an increase of orientational-explorative activity as well as facilitation of handling reactions and communicational relations. It has been established that on the background of the Selank there occurs a long compensation of disturbed psychic functions (processes of memory) and of homeostatic parameters. It has been shown that unlike the earlier studied neurohormones (thyroliberin and ACTH4-10), the antistressor Selank effects do not depend on the type of neurotic disturbances and have long-term compensatory character. Comparison of the data obtained on monkeys with results of similar studies on the more low-organized mammals (rodents) allow suggesting that the new peptide preparation Selank is a promising agent for correction of various psychoemotional disturbances (alarm- and depression-like disorders).

    PMID 18727417 [PubMed - indexed for MEDLINE]
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    [Experimental optimization of learning and memory processes by selank].


    AuthorsSemenova TP, et al. Show all Journal
    Eksp Klin Farmakol. 2010 Aug;73(8):2-5. Article in Russian.


    Affiliation
    Abstract
    The effect of selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro), which is a synthetic derivative of the endogenous tetrapeptide tuftsin (stable with respect to tissue peptidases), on the learning and memory processes and metabolism of serotonin (5-HT) have been experimentally studied on Wistar rats. The animals were trained with food reward in 30 trials per day. Selank (300 microg/kg) or saline were injected after the 10th trial. Elaboration of conditioned reflex with food reward was continued 30 min later. Retention was tested 24 h, 7 and 30 days after treatment. A single injection of selank activated the metabolism of 5-HT in the hypothalamus and caudal brain stem for 30 min to 2 h. It was established that selank induces an increase in memory trace stability during 30 days. These findings provide direct evidence that selank, when injected during consolidation phase, can enhance memory storage processes. Nootrope activity of the selank is probably caused by its obvious effect on the level of serotonin and its metabolite in the brain.
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    I interpret this study to be one of those old studies where they give a rat certain choices and if the rat makes the incorrect choice he is punished. This is what they mean by "conditined active avoidance reflex", if I'm not mistaken. This study shows that rats with below normal learning abilities improve rapidly post selank administration.




    The optimizing action of the synthetic peptide Selank on a conditioned active avoidance reflex in rats.


    AuthorsKozlovskii II, et al. Show all Journal
    Neurosci Behav Physiol. 2003 Sep;33(7):639-43.


    Affiliation
    Abstract
    The actions of the synthetic heptapeptide preparation Selank on learning and memory processes in rats with initially low levels of learning ability were compared with those in normal rats, using a method based on acquisition of a conditioned active avoidance reflex, with repeated administration of peptide 15 min before the start of training sessions for four days. The effects of Selank (300 microg/kg) were compared with the effects of the nootrope piracetam (400 mg/kg). These experiments showed that Selank significantly activated the learning process in rats with initially poor learning ability, with effects apparent after first dose on training day 1. The effect progressively increased on repeated administration of Selank: the total number of correct solutions increased and the number of errors decreased (p < 0.05). The maximum optimizing activity of Selank on learning in normal rats was seen on day 3 of repeated administration and training, i.e., after formation of the initial consolidation phase. The dynamic features of the development of the activating action of Selank and piracetam were described. Comparison of the results obtained here with data on the anti-anxiety actions of Selank suggested potential for its use in optimizing mnestic functions in conditions of elevated emotional tension.


    PMID 14552529 [PubMed - indexed for MEDLINE]
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    [Effects of the new peptide anxiolytic drug selank on the cardiovascular system functioning and respiration in cats].


    AuthorsGan'shina TS, et al. Show all Journal
    Eksp Klin Farmakol. 2005 Jul-Aug;68(4):33-5. Article in Russian.


    Affiliation
    Abstract
    The effects of the new heptapeptide anxiolytic drug selank (300 mg/kg, i.v.) on the arterial pressure (AP), cerebral blood flow, heart rhythm, respiration, and the AP depression induced by acetylcholine injections was recorded in narcotized male cats. Selank produced a 32 +/- 4.3% decrease in the AP for the first 1-3 min after injection. The drug also induced a 24 +/- 2.8% increase in the cerebral blood flow for the first 5 - 10 min upon injection and then the blood flow was gradually restored on the initial level. The heart rate and the respiratory rate were not affected by the drug injections. Nor did selank influence the AP depression in response to the acetylcholine introduction.


    PMID 16193654 [PubMed - indexed for MEDLINE]
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    It was posted on another forum that Selank is helping remove withdrawal symptoms from a chronic pain suffer who is prescribed opiates. That's very interesting as anyone who has ever withdrawn from opiates knows it's pure hell!!!
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    [Efficacy and possible mechanisms of action of a new peptide anxiolytic selank in the therapy of generalized anxiety disorders and neurasthenia].


    AuthorsZozulia AA, et al. Show all Journal
    Zh Nevrol Psikhiatr Im S S Korsakova. 2008;108(4):38-48. Article in Russian.


    Affiliation
    Abstract
    Sixty-two patients with generalized anxiety disorder (GAD) and neurasthenia were studied. The effect of selank (30 patients) was compared to that of medazepam (32 patients). Patient's state was assessed with psychometric scales (Hamilton, Zung, CGI). Enkephalin activity in the blood serum was measured as well. The anxiolytic effects of both drugs were similar but selank had also antiasthenic and psychostimulant effects. The clinical-biological study revealed that patients with GAD and neurasthenia had the decreased level of tau(1/2) leu-enkephalin which was correlated with disease duration, severity of symptoms related to anxiety and asthenia and autonomic disorders. The increase of this parameter and stronger positive correlations with anxiety level were observed during the treatment with selank mostly in patients with GAD.
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    Selank-induced normalizing effects on the integrative brain activity and biogenic amine level disorders due to antenatal hypoxia.


    AuthorsSemenova TP, et al. Show all Journal
    Ross Fiziol Zh Im I M Sechenova. 2006 Nov;92(11):1332-8. Article in Russian.


    Affiliation
    Abstract
    The effects of Selank synthetic analog of Tuftsin, representing the heptapeptide forming Thr-Lys-Pro-Arg-Pro-Gly-Pro, on behavior and serotonin/noradrenalin concentrations in brain were investigated in adult rats exposed to hypoxia during 14-16 days of gestation. It was revealed that injection of Selank (300 mkg/kg, i/p) increased 2--3-fold (p < 0.01) the sensory attention, facilitated 1.5-fold the learning capacity (p < 0.01), normalized exploratory activity in the open field and hole board, and recovered the balance of serotonergic and noradrenergic brain system activity. The data obtained demonstrate the possibility of Selank to compensate for long-lasting negative effects of antenatal hypoxia on integrative brain activity and brain monoamine level.


    PMID 17385425 [PubMed - indexed for MEDLINE]
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    The inhibitory effect of Selank on enkephalin-degrading enzymes as a possible mechanism of its anxiolytic activity.

    Zozulya AA1, Kost NV, Yu Sokolov O, Gabaeva MV, Grivennikov IA, Andreeva LN, Zolotarev YA, Ivanov SV, Andryushchenko AV, Myasoedov NF, Smulevich AB.



    Abstract

    Examination of patients with various forms of anxiety and phobic disorders (according to DSM-4 criteria) demonstrated a considerable shortening of enkephalin half-life and reduced total enkephalinase activity in the blood during generalized anxiety, but not during panic disorders and agoraphobia. This was probably related to low blood concentration of endogenous inhibitors of enkephalin-degrading enzymes in patients with generalized anxiety disorders. Heptapeptide Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro), which attenuates behavioral anxiety reactions and does not cause side effects typical of most anxiolytics, dose-dependently inhibited enzymatic hydrolysis of plasma enkephalin (IC50 15 microM). Selank was more potent than peptidase inhibitors bacitracin and puromycin in inhibiting enkephalinases. These results suggest that high efficiency of Selank in the therapy of anxiety and phobic disorders, including generalized anxiety, is due to its ability to inhibit enkephalin hydrolysis.


    PMID: 11550013 [PubMed - indexed for MEDLINE]
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    P-1114 - Rapid and slow response during treatment of generalized anxiety disorder with peptide anxiolytic selank


    Introduction
    Heptapeptide Selank approved for the treatment of Generalized Anxiety Disorder (GAD). Studies revealed that Selank acts as an anxiolytic with stimulatory and cognitive enhancing properties. Though time to treatment response significantly varied in patients and this issue has not been studied.


    Objectives
    Individual treatment response analysis in Selank-treated patients with GAD.


    Aims
    To compare clinical state and EEG changes in patients with different time to treatment response to Selank.


    Methods
    20 patients aged 24–52 y.o. with GAD according to DSM-IV were included. Selank was administered at the dose 2700 μg/day intranasally. Study utilized valid clinical scales and pharmaco-EEG.


    Results
    40% of patients were rapid responders (RR) and characterized by abrupt reduction of whole set of symptoms in first 1–3 Days. At the Day 3 Hamilton Anxiety Rating Scale (HARS) mean total score [SD] reduced from 20.3[11.9] to 7.0[2.9] (p < 0.01). 60% of patients responded gradually (conventional responders - CR). Clinically significant changes of mean HARS total score from 16.1[7.2] to 6.2[4.7] were achieved at Day 14, p < 0.01. In contrast to CR, RR demonstrated obvious EEG-reaction after single dose (900 μg) with increase of beta-rhythm, decrease of theta- and low frequencies of alpha-rhythm (all p < 0.05). Initially RR and CR significantly differed by the score of asthenic and cognitive symptoms (p < 0.05).


    Conclusions
    Data that peptide anxiolytic drug Selank in patients with GAD exert significant individual variability of therapeutic effect, including rapid effectiveness, confirmed. RR had more asthenic and cognitive symptoms and characterized by a higher EEG-reactivity than CR.
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    Selank and its derivatives had a significant antiulcer effect by increasing the resistance of the gastric mucosa to the factors that contributed to the formation of ulcers.
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    The neurobiochemical spectrum of selank action combines mechanisms which are characteristics of antidepressants and psychostimulants: activation of the brain monoaminergic systems, dopamine synthesis and turnover, and modulation of the tyrosine hydroxylase activity.
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    Is anyone else using selank now? How are you finding it?
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    [Comparison of the effects of selank and tuftsin on the metabolism of serotonin in the brain of rats pretreated with PCPA].


    [Article in Russian]
    Semenova TP, kozlovskiĭ II, Zakharova NM, Kozlovskaia MM.


    Abstract


    Effects of the peptide drugs selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro) and tuftsin (Thr-Lys-Pro-Arg) on the metabolism of serotonin (5-hydroxytryptamine, 5-HT) in the brain of Wistar rats preliminarily treated with the 5-HT-synthesis inhibitor p-chlorophenylalanine (PCPA, 320 mg/kg, i.p., 4 days before experiment) have been studied on a group of 87 matured rats. It is established that selank enhances the 5-HT metabolism in the brain stem 30 min after injection to animals pretreated with PCPA. In contrast to selank, tuftsin induced no changes in the 5-HT metabolism in the brain stem and decreased it in the neocortex on the same time scale. The data obtained suggest that the peptide drug selank can be used for the correction of disturbances induced by a decrease in 5-HT metabolism.
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    Selank has no sedating or cognitive side effects and no associated addiction or withdrawal syndrome.
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    Selank Has An Advantage Over Traditional Anxiety Treatments, Such As Benzodiazepines, As It Has No Sedating ... NO Addiction Or Withdrawal ...
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    [Protective effect of selank on the model of mnestic function violation induced by pharmacological blockade of protein synthesis].


    AuthorsKozlovskiĭ II, et al. Show all Journal
    Eksp Klin Farmakol. 2013;76(12):3-7. Article in Russian.


    Affiliation
    Abstract
    We have studied the ability of peptide anxiolytic selank (Thr-Lyz-Pro-Arg-Pro-Gly-Pro) to compensate for mnestic dysfunction caused by the administration of actinomycin D, which inhibits protein synthesis by blocking DNA-dependent RNA polymerase. The experiments were performed on white rats with acquired adaptive ability of spatial visual orientation in a 16-door labyrinth. The learning was based on the avoidance of electric skin irritation at alternating sites of escape reaction (site reflex). Selank (0.5 mg/kg, i.p.) prevented or compensated for actinomycin D (250 mg/kg, i.p.) induced violation of the process of acquisition, improvement, and consolidation of memory trace during the development of a complex site reflex. The drug administration also reduced the time required for acquisition of the adaptive ability of spatial visual orientation in the labyrinth and restored the actinomycin D violated process of re-learning upon a change in the alternation of escape sites under free-choice conditions.
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