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Androgens-Testosterone=Heart Disease??

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  1. #1
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    Androgens-Testosterone=Heart Disease??

    Just read an article from Australia that male sex hormones(testosterone) cause heart disease because it activates the genes that accelerate deposition of cholesterol in the arteries.They also included strokes and vascular diseases as high risk factors.
    It stated that Androgens were found to stimulate 27 male genes related to heart disease.
    This research was based on natural testosterone levels in males.So where does it leave us if we are doing pro hormones etc.??
    I really gotta wonder what we are doing on a genetic level with our blood and organs.
    Any of you guys do blood tests? Concerned? I am.
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    Most androgens will raise cholestorol levels. They do in me. I have blood work done at least every 6 months.




    Disclaimer: All health, fitness, diet, nutrition, anabolic steroid & supplement information posted here is intended for educational and informational purposes only, and is not intended as a substitute for proper medical advice from a medical doctor. We do not condone the use of anabolic steroids (AAS), all information about AAS is for educational and entertainment purposes only. If you choose to use AAS it's your responsibility to know the laws of the country that you live in. Consult your physician or health care professional before performing any of the exercises, or following any diet, nutrition or supplement advice described on this website.

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    What kind of test results do you get? Anything to worry about DG? I know that's the main idea behind cycling,to avoid these negative sides.I suppose it depends on how much cholesterol is in our diets also.I think long term use could be dangerous.But then whta is long term?
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    They lower HDL and raise LDL, that has been known for a long time which is why you would be advised not to abuse the stuff. You can get blood tests, but most normal people I believe are fine with a healthy diet and sufficient rest time between cycles.

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    Do the levels return to normal after a cycle? And would 1-Test be safer than 1-AD or same?Tks
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    If I get a test done while on cycle or right after, my total cholesterol can be 30-40 points higher.




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    Originally posted by kdwa1
    Do the levels return to normal after a cycle? And would 1-Test be safer than 1-AD or same?Tks
    It should not take very long for a normally healthy person to have thier levels return to normal.

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    Thanks I feel better.The article freaked me a bit but still wonder about long term cycling effects.
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    Worst side of AAS use and how to counter
    Why is it that users don't realize that the worst side of steroid use is a VERY shitty lipid profile. Well I think it's because one cannot SEE a shitty lipid profile and you don't feel bad with it.

    I would venture to say that it is universal with men that are taking even half decent doses of gear.

    Total cholesterol usually doesn't go up that much with roids, although it can climb, and triglycerides sometimes go down but usually stay about the same. What makes steroid use so scarry is the TERRIBLE affect it have on hdl. Hdl(good cholesterol) really takes a dive. Hdl to total cholesterol ratio's are OFTEN as bad as 15 or 20 to 1 and that is very significant indeed. The last time I had my lipid profile checked my doc had a COW!! I don't know if I will ever do test and tren again for a long eight week cycle.
    People with a low hdl have a significantly higher risk for heart disease.
    There is plenty of evidence to suggest that heart disease doesn't happen in a few years in old or middle age. It is most often though to be the result of a slow build up of aterial plaque over many many years and perhaps starting in childhood!

    So with all this in mind it makes sence to limit androgen use as much as possible and to take plenty of time off between cycles.
    Testosterone singled out as heart attack culprit

    Coronary heart disease remains the number one killer in Australia.

    Today, researchers revealed new information about why men are so susceptible to the disease.

    Doctors have long tried to discover why men suffer five times more heart attacks than women.

    Now, new research has singled out the male sex hormone testosterone as the culprit.

    "What the current study has shown is if you take cells that gobble up cholesterol and you expose them to testosterone, the boy cells go crazy, gobble up much more cholesterol than the boy cells, which perhaps explains why men get so much more heart disease than women," Professor David Celemajer from Sydney's Royal Prince Alfred hospital said.

    Researchers from the RPA and the Heart Research Institute looked at the genes of a group of men and women under 35.

    They found testosterone switched on 30 heart disease promoting genes in men, but none in women.

    "Its the equivalent of saying men are from Mars and women from Venus, from a cardiological point of view," Dr Martin Ng said.

    Doctors say the findings mean its even more important that men follow a healthy lifestyle, exercising, not smoking and keeping their weight, cholesterol and blood pressure in check.

    Now scientists have identified why men are more at risk of heart attacks, they are developing treatments which could modify male hormones just in the heart.

    "And that's a possibility that might be three to five years down the track, that we can block heart disease in men or at least prevent its rapid progression without having side effects that make them look more like women," Professor Celemajer said.

    Researchers will now investigate the effect of testosterone in larger groups of men and women.
    WHAT IS CHOLESTEROL
    Cholesterol is a waxy, fat-like compound that belongs to a class of molecules called steroids. It's found in many foods, in your bloodstream and in all your body's cells. If you had a handful of cholesterol, it might feel like a soft, melted candle. Cholesterol is essential forFormation and maintenance of cell membranes (helps the cell to resist changes in temperature and protects and insulates nerve fibers)
    Formation of sex hormones (progesterone, testosterone, estradiol, cortisol)
    Production of bile salts, which help to digest food
    Conversion into vitamin D in the skin when exposed to sunlight.

    Excess cholesterol in the Blood collects on the walls of certain blood vessels decreasing their ability to provide proper blood flow to the tissues fed by these blood vessels. For example, a heart attack occurs when the heart receives insufficient blood flow. High levels of cholesterol also increase the risk of high blood pressure, stroke, and circulation problems.
    Cholesterol can be affected by consuming foods high in fat, but the body also synthesizes cholesterol. Some people that adhere to a low fat diet still have high cholesterol levels because their body synthesizes an excess amount. There are several forms in which cholesterol is present in the body, LDL (the harmful form) and HDL (the helpful form). Depending on the relative levels of these forms, along with the concentration of triglycerides (another type of body fat), certain drugs are more effective then others in correcting the abnormalities. For example, a person with elevated LDL levels and normal triglycerides may be treated with different medications than someone with only elevated triglycerides.

    Drveejay’s RULES to improve over-all Lipid Profiles.

    RULE # 1) Eat a High Fiber Diet

    HIGH FIBER DIETS are great for reducing cholesterol levels and reducing soft arterial plaque. Water soluble fibers (guar gum, citrus pectin, locust beans, etc.) are very viscous, slimy and sticky. Bacteria in the large bowel breakdown the water soluble fibers into short chain fatty acids. It is the fatty acids we believe are responsible for lowering LDL-C and interfere with the adhesive characteristics of plaque promoting regression of atherosclerosis (blockage). It also poses qualities which enable lowering LDL (Bad) Cholesterol thereby reducing total cholesterol, improves GI Motility, and improves Glucose Tolerance.

    RULE # 2) Avoid Fats and Carbs in the same meal. This one’s kind of a no-brainer! As fatty acids and carbs compete as energy sources. Gluconeogenesis mediates and prioritizes this competition in favor of carb utilization. The fatty acids that are NOT needed at this time facilitate cholesterol synthesis and lipogenesis (not in the absence of carbs!). This is a recipe for disaster.

    RULE #3) Eat a diet RICH in Omega 3 Fatty Acids Fish oil supplements are dietary supplements that contain oil from cold water fish such as mackerel, salmon, black cod, albacore tuna, sardines, and herring. The active ingredients in fish oil supplements are essential fatty acids known as omega-3 fatty acids. They typically include eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA).
    Fish oils are noted for their effects in people with high cholesterol and heart disease. Medical research supports that large amounts of fish oil—five to 20 grams daily—may lower the amount of triglycerides, or dissolved fat, in the blood. For more...http://www.dcnutrition.com/fattyacids/.

    RULE#3) LOWER SATURATED FATSNot all saturated fat is linked to elevated cholesterol levels; only a subset of saturated fatty acids have this effect. The effect of saturated fat intake on cardiovascular disease incidence is only mediated through its effect on raising LDL levels. If cholesterol levels are controlled for, then saturated fat has no independent effect. What this means is that if the LDL and HDL levels are adequate, then adjustment of saturated fat intake will have little benefit. This is an important concept because earlier; it was thought that saturated fat intake was an independent factor, but more recently, it has become accepted fact that much of this effect was due to failure to account for fiber intake which typically declines as saturated fat intake increases.

    RULE #4) AVOID TRANS FATTY ACIDSFinally, the role of trans fatty acids needs clarification. Trans fatty acid, although they are technically classified as polyunsaturated fats because of their chemical structure, in general behave more along the lines of saturated fats with regard to their effects on cholesterol. In addition to this property, they also appear to have negative effects on hormonal regulation by interfering with eicosanoids due to their similarity with polyunsaturated fats. Since nutrition labels typically do not list trans fatty acid amounts, look for term "partially hydrogenated" to disclose its presence

    RULE #5) RUN Nolvadex with every cycle (w/ or w/out other anti-E’s)The selective estrogen receptor modulators (SERMs) act like estrogen in bone and cardiovascular tissue and block estrogenic effects in the breast SERMs decrease LDL and cholesterol levels. GREAT TRICK when used with highly androgenic gear!


    RULE #6) USE LIVER DETOXIFIERS year round even if NOT on orals! (Ala, thistle, tylers, liv 52, NAC, etc) are NO-BRAINERS here. Enabling your liver to function optimally, proper cholesterol metabolism and emulsification can take place.


    RULE #7) EXERCISE (cardio/whatever) just be sure to “stay active” other than JUST bodybuilding. Cardiovascular exercise is GREAT for keeping the heart healthy and strengthening circulation.“Reducing the risk of heart attack and other complications of heart disease, cholesterol-lowering drugs are good, but a combination of medications, diet and exercise is better, new research suggests. In a study of people with heart disease, those who took cholesterol-lowering drugs called statins, stuck to a very-low-fat diet and exercised regularly were 67% less likely to have a heart attack or stroke or to die during the 5-year study than people who only took statins.”SOURCE: Journal of the American College of Cardiology 2003;41:263-274.
    For MORE...: http://www.lbl.gov/Science-Articles...rs-runners.html

    Drveejay’s SUPPLEMENT LIST (in order of importance)

    SUPP # 1) Policosanol It is a natural supplement derived from sugar cane. The main ingredient is octacosanol. Octacosanol is an alcohol found in the waxy film that plants have over their leaves and fruit. The leaves and rinds of citrus fruits contain octacosanol, and so does wheat germ oil.

    Policosanol has been shown to normalize cholesterol as well or better than cholesterol-lowering drugs, without side effects such as liver dysfunction and muscle atrophy.Efficacy and safety have been proven in numerous clinical trials, and it has been used by millions of people in other countries. Policosanol lowers harmful LDL-cholesterol and raises protective HDL-cholesterol. HDL-cholesterol removes plaque from arterial walls.

    Policosanol also inhibits the oxidation of dangerous LDL-cholesterol4 which promotes the destruction of blood vessels by creating a chronic inflammatory response. Oxidized LDL can also provoke metalloproteinase enzymes. These enzymes promote blood vessel destruction, partly by interfering with HDL’s protective effect. Studies show that rats treated with policosanol have fewer foam cells, reflecting less inflammatory response causing less blood vessel destruction.

    Healthy arteries are lined with a smooth layer of cells so that blood can race through with no resistance. One of the features of diseased arteries is that this layer becomes thick and overgrown with cells. As the artery narrows, blood flow slows down or is blocked completely. Policosanol can stop the proliferation of these cells in much the same was as lipid-lowering drugs.

    Policosanol also inhibits the formation of clots, and may work synergistically with aspirin in this respect. In a comparison of aspirin and policosanol, aspirin was better at reducing one type of platelet aggregation (clumping together of blood cells). But policosanol was better at inhibiting another type. Together, policosanol and aspirin worked better than either alone.
    Thromboxane is a blood vessel-constricting agent that contributes to abnormal platelet aggregation that can cause a heart attack or stroke. Significant reductions in the level of thromboxane occur in humans after two weeks of policosanol.

    www.lifeextension.com/references.)

    SUPP # 2) Red yeast rice. It is one of the better studied of these cholesterol-lowering supplements. There have been a number of clinical studies both in China, where it originated, and in the United States, showing that people who consume this red yeast rice along with a sensible diet can see a reduction in their cholesterol levels. It’s pretty powerful stuff because it contains a chemical called lovastatin. The same active ingredient found in a popular prescription drug used to lower cholesterol. That similarity has caused the FDA to take action against one company (go figure!). Red yeast rice also seems to have very few side effects.

    SUPP # 3) Phyto-Sterol Complex It is 100% vegetable derived and provides naturally-occurring sterols including: Beta Sitosterol, Campesterol, and Stigmasterol. Similar in action to the SERMS (nolvadex) Phytoestrogens are plant substances that have weak estrogenic activity in some tissues and block the effects of estrogen in others. They are found in herbs and plant foods, especially soybeans. Soybeans are rich in isoflavones, particularly genistein and daidzein. The FDA stated that foods containing soy protein included in a diet low in saturated fat and cholesterol may reduce the risk of CHD by lowering blood cholesterol levels. The FDA has authorized use of labeling health claims about the role of plant sterol or plant stanol esters in reducing the risk of coronary heart disease (CHD) for foods containing these substances. This interim final rule is based on FDA's conclusion that plant sterol esters and plant stanol esters may reduce the risk of CHD by lowering blood cholesterol levels.

    SUPP # 4) Vitamin E (tocopherol). It seems to interfere with the liver's ability to make cholesterol. Vitamin E is an anti-oxidant that protects cell membranes and other fat-soluble parts of the body, such as LDL Cholesterol (the “bad” cholesterol), from damage. Only when LDL is damaged does cholesterol appear to lead to Heart disease and vitamin E is an important antioxidant protector of LDL. Several studies have reported that 400 to 800 IU of natural vitamin E per day reduces the risk of heart attacks.

    SUPP # 5) Lecithin It is a lipotropic (a fat emulsifier). Its primary function is to metabolize fat and cholesterol, so that it does not settle in the artery wall or in the gall bladder. Many of the positive effects of lecithin consumption are based on the fact that lecithin is a major source of choline. Choline is a lipotropic substance… As choline increases fat metabolism it has been shown that it lowers blood cholesterol.

    Other “Maybe’s” with “good potential”

    Garlic I’m slowly becoming skeptical after reading MANY well documented studies conveying that Garlic/Allicin is “decent at first” but essentially USELESS After 90 days! But until I read more CONCLUSIVE evidence, I will not totally dismiss its benefits. Here’s ONE example: http://www.berkeleywellness.com/htm...GarlicPills.php

    Guggul Is a resin from the guggul tree, has been used for more than 2,000 years in India to treat a range of disorders. In the 1980s, an extract of the resin--dubbed gugulipid--began to be marketed as a cholesterol-lowering agent. The plant compound's mode of action is quite different from that of cholesterol-lowering statin drugs. This means that it or other compounds that work similarly could potentially be used in combination with statins. Some of guggul's active components, guggulsterones, work by blocking a substance that stops the body from getting rid of cholesterol. Statins, on the other hand, block the body from making more cholesterol.In addition to lowering cholesterol, guggul has anti-inflammatory activity. The dosage of guggulsterones is 25 mg two or three times daily. Most extracts contain 2.5–5% guggulsterones and can be taken daily for 3 to six months as a cholesterol lowering agent.

    Alfalfa leaf Animal studies show that alfalfa leaf reduces blood cholesterol and plague deposits on artery walls.

    Green barley has been used for centuries because of its high content of vitamins, minerals, essential fatty acids, enzymes, chlorophyll, various antioxidants, and many unknown natural substances with powerful properties. Has been shown to lower LDL (bad cholesterol) levels. Known to lower blood sugars and insulin levels in clinical studies.

    Selenium It is the oxidized form of low-density lipoproteins (LDL, often called "bad" cholesterol) that promotes plaque build-up in coronary arteries. Selenium is one of a group of antioxidants that may help limit the oxidation of LDL cholesterol and thereby help to prevent coronary artery disease.

    Inositol-Hexaniacinate is a form of Vitamin B-3 (but more superior). It assists in the breakdown and utilization of fats, proteins, and carbohydrates. It also reduces serum lipids. Unlike niacin which may cause flushing, headaches, and stomachaches, Inositol-Hexaniacinate is almost always safe although some rare liver problems have occurred at amounts in excess of 1,000 mg per day. Due to possible hepatotoxic effects, I do NOT recommend straight Niacin. High doses of Niacin can also be responsible activating peptic ulcers, impairing glucose tolerance, and precipitating gouty attacks. And many niacin-takers suffer from flushing, headaches, nausea, heartburn, and diarrhea. There are better choices—above.
    I had something (I think) on how long it took for cholesterol levels to return to normal, but can't seem to locate it, I will try to look later.

  10. #10
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    Excellent read,Alot to think about.What do you think is safest for us to use or are all test boosters the same?
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    Test is test once inside the body.

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