How arginine enhances the effect of GABA

Results 1 to 1 of 1
  1. #1
    The Purple One
    ADMINISTRATOR
    Prince's Avatar


    Join Date
    Nov 2000
    Gender
    Male
    Posts
    72,729

    Thanks Thanks Given 
    459
    Thanks Thanks Received 
    1,058
    Thanked in
    825 Posts
    Rep Points
    2147483647


    Post How arginine enhances the effect of GABA

    How arginine enhances the effect of GABA

    GABA improves sleep and increases the release of growth hormone, but the effect of supplementation is often modest. This is mainly because it is difficult for GABA to pass to blood brain barrier, and to reach the brain. In 2002, researchers from the University of Madras in India published an animal study showing that L-arginine increases GABA uptake by the brain.

    Study
    The researchers experimented with rats. They gave their test animals injections with compounds such as L-arginine and GABA in their small intestine. To some degree, this form of administration imitates the effect of oral administration.

    Results
    Both L-arginine and GABA increased the GABA concentration in the brain of the rats. The combined addition of L-arginine and GABA, however, caused an even greater increase in GABA concentration.

    L-Arginine is a precursor of nitric oxide [NO]. The arginine analog N-nitro-L-arginine methyl ester [L-NAME] blocks the conversion of L-arginine to NO. Administration of L-NAME ensured that L-arginine no longer increased GABA uptake by the brain.

    Conclusion
    "Our study shows that L-arginine increases blood-brain barrier permeability to GABA and that L-NAME completely abolishes this", write the researchers. "We believe that these effects are mediated by NO and that NO contributes to increased blood-brain barrier permeability to GABA."

    If that's right, then supplements like beet juice or L-citrulline could also improve the effect of GABA. And probably those combinations work even better than the combination with L-arginine.

    Source: Brain Res Bull. 2002 Jan 15;57(2):231-6.
    Attached Images Attached Images
    • File Type: gif 1.gif (35.9 KB, 4 views)
    • File Type: gif 2.gif (37.7 KB, 4 views)
    CONTACT ME BY Private Message or Email FOR ADVERTISING OPPORTUNITIES!



Similar Threads

  1. BPC-157 enhances HGH
    By JJB1 in forum Research Chemicals
    Replies: 1
    Last Post: 06-02-2015, 09:56 AM
  2. Garlic enhances slimming effect of running
    By Prince in forum Muscle Central
    Replies: 0
    Last Post: 03-26-2013, 09:20 PM
  3. Replies: 0
    Last Post: 08-22-2012, 10:40 AM
  4. Bacopa Formula Enhances Cognition
    By Prince in forum Muscle Central
    Replies: 0
    Last Post: 06-27-2011, 12:57 PM

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •  
Copyright© 2001-2019 IronMag® Bodybuilding Forums