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The luck was a natural product called gossypol. ???Gossypol occurs in cottonseed, and it???s been a known anti-viral and anti-fertility drug,??? Deck explained. Chinese men who used cottonseed oil became infertile and gossypol was identified as the causative agent. The men regained fertility three months after discontinuing use of the oil.??? The literature indicated that gossypol worked by inhibiting one particular enzyme: sperm-specific lactate dehydrogenase (LDH).
Cottonseed oil's contraceptive effect in men was first discovered in China when men became infertile after eating food cooked in the oil.