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Oxytocin(Oxitocyn)

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  1. #1
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    Oxytocin(Oxitocyn)






    I have a botle Oxytocin(Oxitocyn) hormone 10 ml and i will use it with anabolics cycle.
    but i dont know in what doses or how often .
    I search to find it but i didnt find anything.Anyone know something about this stuff?

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    http://arbl.cvmbs.colostate.edu/hboo.../oxytocin.html

    http://en.wikipedia.org/wiki/Oxytocin

    oxytocin stimulates myoepithelial cells, causing milk to be ejected into the ducts of the mammary glands. Sucking by the infant at the nipple stimulates oxytocin release.
    Or did you mean oxycontin? Oxycontin is addictive and has killed a few known lifters, it has no purpose at all as an anabolic.

  3. #3
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    Mudge
    Thanks for the links......and
    No i didnt mean oxycontin.
    I check the links but i still have many questions
    about if Oxytocin worth to try it .I cant see any benefits from it.
    How Oxytocin suppose to help to build muslce?


    Thanks for your time.....

    Mudge

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    its not...its not a muscle building substance...just because something is a horomone or a steroid, dosent mean its going to build muscle...Its a very big misconception among many people

    most horomones supplied these days in the medical arena are for girls and thier fertility probs etc....hell, Some steroids are designed to actually to eat muscle

    In short dude, you have a horomone that will make you babies healthier and your boobs produce better milk.(let me know how the cycle goes. And post pics )

  5. #5
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    Power Rabbit,
    Maybe you are right,that its not a muscle building substance but i read somewhere that is raise the pgf2a and inhibit the cortisol some kind.Anyway iam not going to try it until i find some more info for side effects or anything else about this hormone.
    Any comments or info is very welcome.
    Attached Images Attached Images

  6. #6
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    I read an article where two guys broke into a pharmacy to steal oxycontin and got oxytocin instead. They got caught after taking large amounts trying to get high, I guess it increases estrogen or something because they cried like girls. So good luck, I guess. Nice pic though probably wound't try to screw it up trying new things.

  7. #7
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    Seems to me it would give you some nice puffy nipples, give you the urge to lick little babies and rev up the speed of your seedlings(sperm)
    Coarse edged youth, the irish pendants string from their smiles
    not yet plucked as to slacken the seams
    and drag down the features of age,
    no folds or creases from unkempt wear
    eyes of tranquilty, crystalline-beads
    no sign of despair in their hair, nor their hearts
    but oh they have yet to be experienced and that makes aging so very worth it...ML circa2012

  8. #8
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    I find this.............
    If you have time you can read it.


    The present observations of an OT(Oxytocin) effect on steroid and
    IGF-I release by porcine follicles confirm previous reports
    of an OT action on the granulosa cells of pigs and other
    species (Wathes 1989, Schaeffer & Sirotkin 1995, Sirotkin
    1995, 1996b, Sirotkin et al. 1996). On the other hand, this
    is the first report of an OT influence on porcine IGF-I,
    IGFBP-3, PGF and PGE.

    Attachment: 1590313.txt

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    .

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    .

  11. #11
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    Isolated porcine ovarian follicles as a model for the study of
    hormone and growth factor action on ovarian secretory activity
    A V Sirotkin, A V Makarevich, J Kotwica1, P-G Marnet2,
    H B Kwon3 and L Hetenyi
    Research Institute of Animal Production, 949 92 Nitra, Slovak Republic, 1Institute of Animal Reproduction and Food Research, 10–718 Olsztyn-Kortowo,
    Poland, 2Laboratoire de Recherches sur la Traite, INRA/ENSAR, 35042 Rennes Cedex, France and 3Department of Biology, Chonnam National University,
    Kwangju 500–757, Korea
    (Requests for offprints should be addressed to A V Sirotkin)
    Abstract
    The aim of our in vitro experiments with isolated
    porcine ovarian follicles was to study the effects of
    gonadotropins, GH, IGF-I and oxytocin (OT) on release
    of ovarian steroid, OT, IGF-I, insulin-like growth factorbinding
    protein-3 (IGFBP-3), prostaglandin F (PGF),
    prostaglandin E (PGE) and cAMP.
    It was found that quarters of ovarian follicles cultured for
    8 days produced significant amounts of progesterone,
    estradiol-17 beta, OT and IGFBP-3 with peaks of accumulation
    from the 3rd to the 8th day of culture. Addition
    of serum promoted progesterone, estradiol and OT release,
    whilst accumulation of IGFBP-3 was maintained to a
    greater extent in serum-free medium.
    GH (10 ng/ml or above) was able to inhibit androstenedione,
    OT, PGF and IGFBP-3, to stimulate IGF-I and
    cAMP, and to alter testosterone and PGE release by
    follicles cultured in serum-supplemented and/or serumfree
    medium. IGF-I (10 ng/ml or more) inhibited androstenedione
    and PGF secretion, stimulated testosterone,
    estradiol, OT and cAMP production, but did not influence
    progesterone, IGFBP-3 or PGE output in these conditions.
    -------- >>>>>>OT (100 ng/ml) was able to inhibit androstenedione
    and to stimulate testosterone, IGF-I, PGF and PGE,
    but not estradiol or IGFBP-3 release. A stimulatory effect
    of LH on progesterone and OT and an inhibitory
    influence of LH on estradiol secretion in the serumsupplemented
    medium were observed. FSH in these
    conditions stimulated OT, but not progesterone or
    estradiol secretion. <<<<<<<<<<<<<<----------------
    The use of this experimental model suggests the involvement
    of gonadotropins, OT, GH and IGF-I in the
    control of ovarian steroid and nonapeptide hormone,
    growth factor, growth factor-binding protein, prostaglandin
    and cyclic nucleotide production. The stimulatory
    effect of GH on IGF-I, and the stimulatory influence of
    IGF-I on OT, as well as coincidence of the majority of
    effects of IGF-I and OT, suggest the existence of a
    GH–IGF-I–OT axis. On the other hand, the different
    patterns of action of GH and IGF-I on OT, estrogen and
    IGFBP-3 suggest that part of the GH effect on ovarian
    cells is IGF-I independent.
    Journal of Endocrinology (1998) 159, 313–321
    Introduction
    There is a growing body of evidence that ovarian function
    is controlled not only by gonadotropins (Hillier 1991,
    Sirotkin & Nitray 1994b, Sirotkin et al. 1994, Erickson
    1995, Erickson & Danforth 1995), but also by other
    substances of hypophysial or extra-hypophysial origin. In
    particular, growth hormone (GH) ( Jia et al. 1986, Sirotkin
    & Nitray 1994a, Sirotkin & Schaeffer 1995, Sirotkin
    1996a), insulin-like growth factor-I (IGF-I) (Giudice
    1992, Paton & Collins 1992, Spicer & Echternkamp 1995,
    Sirotkin & Makarevich 1996), oxytocin (OT) (Wathes
    1989, Schaeffer & Sirotkin 1995, Sirotkin 1995, 1996b,
    Sirotkin et al. 1996) and prostaglandin (Dennfors et al.
    1983, Satoh et al. 1984, Michael et al. 1994) can regulate
    gonadotropin receptors, secretion of growth factors, steroid
    and nonapeptide hormones, prostaglandin F2-alpha (PGF)
    and cyclic nucleotides by rodent, bovine and human
    ovarian cells.
    In pigs, effects of gonadotropin (Hillier 1991, Sirotkin
    & Nitray 1994b, Sirotkin et al. 1994, Erickson 1995,
    Erickson & Danforth 1995), OT (Schaeffer & Sirotkin
    1995, Sirotkin 1995, 1996b, Sirotkin et al. 1996) and
    prostaglandin (Dodson & Watson 1979, Michael et al.
    1994) on ovarian secretions have been reported. On the
    other hand, there is very little information on the effects of
    GH and IGF-I on ovarian secretion in this species. Only
    an increase in IGF-I production after GH treatment, as
    well as a stimulatory influence of both GH and IGF-I
    on porcine ovarian steroidogenesis, has been reported
    (Giudice 1992, Spicer & Echternkamp 1995). These data
    suggest indirectly that IGF-I is a mediator of GH action on
    313
    Journal of Endocrinology (1998) 159, 313–321 ? 1998 Society for Endocrinology Printed in Great Britain
    0022–0795/98/0159–313 $08.00/0

    ovarian steroid secretion. On the other hand, the influence
    of GH and IGF-I on porcine ovarian growth factorbinding
    protein, OT, prostaglandin and cyclic nucleotides,
    which may be also mediators of hormone and growth
    factor action, has not yet been studied.
    To understand the role of various peptide hormones and
    related substances in the control of ovarian secretory
    activity, as well as to obtain indirect evidence on their
    possible inter-relationships, a comparison of their effects on
    the secretion of various substances by porcine ovarian cells
    is necessary.
    Most in vitro studies of the ovary have been performed
    on cultured granulosa cells. It is known, however, that the
    complete, long-term production of ovarian secretions
    requires functional integrity of the theca and granulosa
    compartments of the follicle (Hillier 1991, Erickson 1995).
    In an attempt to find an adequate model for the study of
    ovarian steroidogenesis during follicular development and
    after gonadotropin treatment, several procedures for the
    culture of whole mouse (Boland et al. 1993, Spears et al.
    1996), bovine (Staigmiller et al. 1982, Kruip & Dieleman
    1989), sheep (Terlou et al. 1988, Mann et al. 1992) and
    porcine (Dodson & Watson 1979) ovarian follicles have
    been developed. In these systems, short-term (3 h to 2
    days) perfusion with oxygenated serum-supplemented
    medium is usual. These perfusion systems have been used
    to study inter-relationships between gonadotropin, steroid
    hormones and prostaglandins within the ovary. Follicles do
    not appear to have been used previously for the study of
    GH, growth factors and their binding proteins, OT or
    intracellular messengers.
    The aims of our study were: (1) to determine the value
    of isolated quarters of porcine ovarian follicles for longterm
    culture in serum-free or serum-supplemented
    medium and the production of hormones and other
    biologically active substances, and (2) to study the influence
    of GH, IGF-I, OT, luteinizing hormone (LH) and
    follicle-stimulating hormone (FSH) on growth factor,
    growth factor-binding protein, steroid and nonapeptide
    hormones, eicosanoid and cyclic nucleotide secretion by
    these follicles.
    Materials and Methods
    Isolation and culture of ovarian follicles
    Ovaries from non-cycling, Slovakian white gilts, 180 days
    old, without visible reproductive abnormalities, were
    obtained at a local slaughterhouse. Ovarian follicles
    were collected and processed according to Golubev &
    Zavertjajev (1989) with several modifications. Briefly, 1 h
    after slaughter the tissues surrounding the ovary were
    removed and the ovaries opened with scissors at the site of
    entry of blood vessels. The connective tissues inside the
    opened ovary were gradually broken with large surgical
    forceps in order to access the follicles. Follicles 3 mm in
    diameter without visible signs of atresia were pressed down
    and separated from the surrounding connective tissues
    with small forceps. They were collected in a Petri dish and
    washed four times in sterile Dulbecco’s modified Eagle’s
    medium/F-12 1:1 mixture (Sigma, St Louis, MO, USA)
    supplemented with 10% heat-inactivated fetal calf serum
    (FCS, University of Veterinary Medicine, Brno, Czech
    Republic), and 1% antibiotic–antimycotic solution
    (Sigma). The follicles were then cut with small scissors into
    four equal parts, and washed gently, avoiding detachment
    of granulosa cells from the follicular wall. Quarters of
    follicles were placed individually in 24-well plates
    (Beckton Dickinson GmbH, Heidelberg, Germany) with
    2 ml medium. In the first series of experiments (studies of
    hormone accumulation in follicle-conditioned medium)
    follicles were cultured for 8 days with or without FCS at
    37·5 )C in humidified air. The incubation medium was
    collected on days 0, 1, 2, 3, 4, 6 and 8 of culture.
    Microscopical examination of the cultures after 8 days
    showed that granulosa cells remained attached to the
    follicular wall; only insignificant numbers of cells started to
    grow away separately. In the second series of experiments
    (studies of hormone and growth factor effects on secretory
    activity) follicles were cultured for 4 days in serumsupplemented
    and, in some cases, also in serum-free
    medium in the presence of recombinant porcine GH
    (rpSTH, Research and Development, Pittman-Moore
    Inc., Terre Haute, USA; 0, 10 or 0, 10, 100 or
    1000 ng/ml), recombinant IGF-I (Calbiochem, Lucerne,
    Switzerland; 0, 10 or 0, 1, 10 or 100 ng/ml), porcine
    LH (National Hormone and Pituitary Program, Ogden
    BioService Corp., Rockville, USA; 0 or 10 ng/ml),
    porcine FSH (SPOFA, Prague, Czech Republic; 0 or
    10 ng/ml) or synthetic OT (Sigma; 0 or 100 ng/ml). The
    blank control was represented by medium cultured without
    follicular tissue. After culture, the follicle quarters were
    weighed and the medium stored at "20 )C until analysis.
    Immunoassay
    Hormone, growth factor-binding protein and prostaglandin
    concentrations in 25–100 µl incubation medium were
    determined in duplicate without extraction. Progesterone,
    androstenedione, testosterone, estradiol and insulin-like
    growth factor-binding protein-3 (IGFBP-3) were analyzed
    using commercial IRMA kits from DSL (Webster,
    TX, USA). The RIA kit for cAMP assay was from
    Immunotech (Marseille, France). PGF and prostaglandin
    E (PGE) were determined using an RIA kit from the
    Institute of Isotopes (Budapest, Hungary) or the RIA
    described previously (Cetta & Goetz 1982, Chang et al.
    1995). IGF-I was measured according to the method of
    Furlanetto et al. (1977). OT was determined using our
    RIA or EIA described previously (Kotwica & Skarzynski
    1993, Marnet et al. 1994). The characteristics of these
    assays are presented in Table 1.
    A V SIROTKIN and others · Hormone action on ovarian follicles 314
    Journal of Endocrinology (1998) 159, 313–321

  12. #12
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    Originally posted by mikey_7777
    Isolated porcine ovarian follicles as a model for the study of
    hormone and growth factor action on ovarian secretory activity
    Since your name is Mikey I think we figured you were a man. Do you have ovaries you haven't told us about?

  13. #13
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    if ya want to raise your igf-1 levels...get a igf kit and jab it

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    Hey...Oxytocin...that's the cuddle hormone! It's produced by your body when you cuddle with someone...it's associated with being empathetic, falling in love, all that stuff.

    I guess that makes sense that you'd cry like a teenage girl if you had too much of it...but I figure, it's probably perfectly healthy in smaller doses, especially if you aren't getting cozy very often.

    I've read it also has something to do with male sexual function, ejaculation, something like that. And...it is good for the immune system.

    Tell me if you notice any changes after taking it, especially in your mood. I would be very curious. I can't believe that you wouldn't...
    Eat Papayas!

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