Two women found with HIV-immune mutant gene

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    Two women found with HIV-immune mutant gene

    http://www.chinadaily.com.cn/english...ent_379267.htm

    Two women found with HIV-immune mutant gene
    Wang Zhuoqiong
    2004-10-01 05:17



    SHENZHEN: Two women have been identified as carrying a mutant gene that is immune to HIV/AIDS, the first such cases uncovered in China, a researcher said.

    The finding is the joint effort of a research programme, "Association of Human Genetic Polymorphisms with HIV Affections," jointly conducted by the University of Washington in the US State of Washington and local Infectious Disease Hospitals and medical institutions in Guangdong Province.

    Tuofu Zhu, associate professor of University of Washington and associate director of the Clinical Core at the Centre for AIDS Research (CFAR), introduced the programme to China a year ago as a part of his global research in nations in Europe, the Americas, Africa and Asia.

    "Before, such mutant genes were only found in Caucasians. The finding has encouraged us to do further research in China, with the aim of developing medicines to prevent and cure HIV/AIDS for different races,"said Zhu.

    China is now at a key moment in adopting effective measures to control and prevent HIV/AIDS as the disease moves from high risk populations to the general population, in most cases though sexual transmission, Zhu pointed out.

    Zhu said that setting up a research centre in Guangdong Province is appropriate as its population has made it the best platform for collecting diversified samples.

    "With the largest mobile population in China, we can get samples from migrants who are from other parts of the country," said Zhu.

    Since a greater number of patients infected with sexual transmitted disease in particular are reported in Guangdong Province, sample collections are more efficient than other regions in China, Zhu added.

    So far, according to Zhu, his programme in Shenzhen has identified 11 Exposed Seronegatives (ES) since January.

    Zhu explained that the immune systems of some individuals may be capable of resisting HIV infection. These individuals who do not appear to be infected with HIV despite multiple sexual encounters with HIV infected partners are referred to as exposed seronegatives (ES).

    To be specific, any one who has conducted sexual activities at least twice weekly in four consecutive months with an HIV-infected partner might be identified as ES.

    Of 11 ES cases, two cases have later been identified as carrying the mutant genes.

    In Zhu's opinion, if medicine functioning similarly with the genes was put in the vagina and rectum, the HIV virus couldn't find its carrier to enter the human body and thus would be expelled.

    In Shenzhen, both confirmed samples are women who have been exposed to HIV for many years but remained uninfected.

    One of them, in her 40s, has kept a regular sexual life with her husband without any protection measures for nine years. Her husband, who was infected with the deadly virus by blood transfusion in 1994, was hospitalized in Shenzhen's Donghu Hospital in July last year.

    However, due to the limited qualified samples, Zhu said it is still too early to draw any conclusion from the programme, adding "we definitely need more support from the local hospital, medical institutions and government to collect more data from ES people."

  2. #2
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    It could be a big step ...

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    Interesting. I don't think they will find a cure though, maybe a vaccination?
    P-side Inc.

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    Quote Originally Posted by PreMier
    Interesting. I don't think they will find a cure though, maybe a vaccination?
    Lol, Id love to see that conversation.
    "Alright Eddy, Heres what we're going to do. We've given weakened HIV cells to other people, and they didnt get infected.. but they also didnt develop an immunity.. So, we're going to give you less weakened HIV and see what happens.. ready?"





















    "Almost forgot, Heres your sign."

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    happy sumo
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    Quote Originally Posted by Chain Link
    "Almost forgot, Heres your sign."
    What does this mean?
    P-side Inc.

    "the post-workout high is more profound than any drug-induced rush imaginable." -Dante B.

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    Quote Originally Posted by PreMier
    What does this mean?
    Well, I guess the best definition would be that it means,"You're stupid."

    Its one of Bill Engvall's joke series. He says things like instead of putting warnings on products ect, we should just have the stupid people wear signs, and we just wouldnt sell them the product.

    Stupid people should have to wear signs that just say, "I'm Stupid". That
    way you wouldn't rely on them, would you? You wouldn't ask them
    anything. It would be like, "Excuse me...oops, never mind. I didn't see
    your sign."
    A couple of months ago I went fishing with a buddy of mine, we pulled his
    boat into the dock, I lifted up this big 'ol stringer of bass and this
    idiot on the dock goes, "Hey, y'all catch all them fish?" "Nope. Talked
    'em into giving up. Here's your sign."
    I was watching one of those animal shows on the Discovery Channel. There
    was a guy inventing a shark bite suit. And there's only one way to test
    it. "Alright Jimmy, you got that shark suit on, it looks good... They want
    you to jump into this pool of sharks, and you tell us if it hurts when they
    bite you." "Well, all right, but hold my sign. I don't wanna lose it"
    So I was saying whoever voulenteered to test out the vaccine would be pretty stupid. Of course we dont really test vaccines that way.. but theres always got to be a first person..

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    Ok, thanks
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    Quote Originally Posted by PreMier
    maybe a vaccination?
    I don´t see that happening any time soon, the virus acts the same way of the flu virus.

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    Quote Originally Posted by Vieope
    I don´t see that happening any time soon, the virus acts the same way of the flu virus.
    I dunno how things are in brazil, but we have a flu vaccine in the US

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    Gene therapy
    "If you're not part of the solution, you're the precipitate."

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    Quote Originally Posted by Chain Link
    I dunno how things are in brazil, but we have a flu vaccine in the US
    We have that too but it is not 100% efficient. The virus changes a lot.

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    Quote Originally Posted by Luke9583
    Gene therapy
    This is what I was wondering also.. could stem cell research cure AIDS?
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    Quote Originally Posted by PreMier
    This is what I was wondering also.. could stem cell research cure AIDS?
    No, stem cell will be used to generate new cells. Since the infected cells of AIDS is in the whole body it can´t be done. Damn, I am such a geek.

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    Couldnt anti viral cells(like found in the above mentioned people) be created? I mean it might be limited to blood/ethnicity, but could it work?

    Learn me G33K
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    I don´t think so. I guess rejection of the anti-viral cells would happen.

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