Potassium regulates plasma testosterone and renal ornithine decarboxylase in mice.
Sanchez-Capelo A, Cremades A, Tejada F, Fuentes T, Penafiel R.
Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Murcia, Spain.
Potassium deficiency produced different effects in the kidney of male or female mice. While in female, potassium deficiency caused a marked renal hypertrophy with no significant changes in testosterone-regulated enzymes, such as ornithine decarboxylase and beta-glucuronidase, in the male the same treatment provoked a marked fall of these enzymes owing to a dramatic decrease in plasma testosterone. Potassium replenishment restored plasma testosterone and renal enzymatic activities. These results show for the first time, that potassium modulates circulating testosterone and suggest that this cation could exert an important regulatory role in controlling androgen actions.
"Estrogens are conjugated with glucaric acid in the liver for excretion via bile. An enzyme called beta-glucuronidase from intestinal bacteria can convert conjugated excreted estrogen back into an active form that can be reabsorbed. A diet high in vegetable fiber provides a substrate for optimal bacterial growth with reduced levels of beta-glucuronidase, and encourages a rapid transit time and enhanced elimination of excretory substances."
Note that magnesium counteracts beta glucuronidase, and also ornithine decarboxylase - an enzyme that causes cell death in the absence of magnesium. Silymarin also counteracts beta-glucuronidase.
Pretty cool, eh?
For female forum readers who have PMS problems:
"It may also be that the ovaries are functioning fine, but hepatic metabolism and excretion of estrogens is impaired. Dr Morton Biskind in the 1940s showed that B vitamin deficiencies caused liver impairment and accumulation of estrogens that contribute to PMS, fibro-cystic breast disease and menorrhagia. B vitamins, in particular B6, are required for the hepatic metabolism of estrogens prior to excretion and it is reasonable to extrapolate that B vitamin deficiency contributes to estrogen loading and PMS in a significant way.
This is one of the reasons I recommend glucuronolactone, from BN. Beyond this estrogen removal action in the liver, its one of three typies of bile acid conjugation mechanisms (along with NAC and taurine).
Estrogen therapy and the birth control pill are known to contribute to cholestasis (the so-called sluggish liver) and so there may be a vicious cycle where B vitamin deficiency causes diminished estrogen clearance and elevated estrogen impairs liver function. Bitter hepatic stimulants and cholagogues are called for here (Taraxacum off., Berberis vulgaris, Fumaria off., Arctium lappa, Curcuma longa), along with nutritional co-factors such as B vitamins, methionine, phosphatidyl choline, inositol, N-acetyl-cysteine and glutathione. "
Note: these are the agents of the transsulfuration cycle.
Speaking of menstruation. My girlfriend has insanely painfull menstruation cramps. It's so bad that she's considering to be on the contraceptives again.
I'm gathering all the possible data on it but everytime I read something I have a stupid feeling that it's again very badly understood (well look who's talking again ). No solutions for the cause (not even the cause).. just blah blah blah...
So it's only up to the proper regime to fix the problems for good. Diathermy is said to help releive the pain.
GF may have developing endometriosis. She needs to be seen by a physician; they can evaluate her for this possibility. She should not go on bc pills. She has a PGE2 amd PGF2A abnormality, with elevated estrogen and unusually high aromatase expression (if she has endometriosis). Grapefruit, eaten daily, will help reduce this enzyme activity. She needs to control the ratio between estrogen and progesterone, and between estrogen and estrone.
We both know that pills are a fucked up idea which doesn't solve anything and will cause more problems in the future. The problem is she's very desperate when the pain strikes. She's having these very painfull cramps since she started having periods. From now on I'll be driving her to the diathermy procedure everytime she'll be having her period to eliminate the pain.
She has undergone diagnostics for endometriosis but none was found. But from what I've heard from her, her doctor has been sleeping on the job. As a start she should go for some ultrasound tests for things like fibroids (there are cases of young women having them) and all other possibilities.
She'll go for a serious welness program like I have. 2 last months I've been reading&practicing the stuff on Qi-qong and some Taoist practices. Sounds like mumbo-jumbo but it really covers the way how the brain/thought/feel works. I was looking into it from fun but when i had my first success i realized there is really something to it. Not scientificaly explained but explained in a natural "feel" way that every human can understand by simply feeling it. Anyone who wold explain it from the deep scientific way would probably score a nobel in no time
Many many many benefits on having control over your nerve system. Redirecting stress from gut and scattering it into the nerve impulse exits, transforming stress into positive feelings or even sexual energy. Once you try it and have the first success with it you never come back. Start with the Bruce Kumar Frantzis's book : Opening the energy gates of the body, and after knowing how to develop the downward currents you can continue with more specific things by authors like Mantak Chia. Have fun with it
She needs to have her diet modified to help with glutathione issues. I helped a member on M2 whose gf had very similar issues (she was also under a lot of self imposed family stress). This member was already very knowledgable, we just discussed some additional supplements and relaxation therapy. His gf has IBS as well. Both conditions have responded well.
I advocate qigong elsewhere. I read Bruces book (Energy Gates) couple years ago and then began reading on parallels, which he candidly discusses, in yoga practices as well. They are coincident in their ability to re-estabilish soft tissue, muscle, connective and bone structure alignment that allow normalized flow of nerve brain/body feedback signal pathways.
This is fundamental to health. Understood in the East for nearly 1000+ yrs, and widely practiced. At Iron Addicts, I have begun to discuss these principles (you can find my references to Bruces books there) - I am moving slowly - these are very foreign ideas to the Western experience. I advocate Tai Chi for regularized maintenance of alignments, and yoga and qigong for major realignment - must be done under the direction of a specialist, not for the novice. Understood?
In the East, we can presuppose that the standard ethinic diet is healthy. Not so here in the West. Other, more recent changes in lifestyle are encroaching on health status as well (brain excitatory activities in excess). This is now, ironically, becoming an issue within younger generations in both the East and West, due to the effects of the internet and cultural globalization.
So, a total package of heathy practices must be adopted for people of any culture, to ensure health and wellness and avoid undue risks, where they are preventable by the average person. Due to deteriorating environmental conditions, additional protective measures are necessary - these are foreign to Eastern medicine, but have some parallels in their enthobotantical pharmacia (holistic medical use of herbs and minerals).
This is quite an advanced topic (body nerve meridian and node alignment) for Iron Magazine forums.
Wish I had read about all the health things ages ago. Would have much more time to bring me to balance. And balance is the key. The balance will bring in the most intensive and long lasting hapiness. Nature rewards balance.
But knowing too much can be a real burden. Knowing too much brings in imbalance. I see it how I insanely overdone it in the sexuality&psychology field. I could write up a big paper exposing all the myths in which this foolish society lives. But existence of these myths is actually essential for the society to survive. Again there has to be a balance between knowing and not knowing. What it ussualy means is that there's almost no way that an individual would look for the truth unless he had to save his own skin. Just another of nature's mechanisms. We're just toys in the hands of the nature.
When certain practices become ingrained into daily practice, and when use of certain corrective techniques are considered as valuable tools alongside standard medicine and herbal pharmacopea, then you have a holistics lifestyle.
This is the thousand-plus tradition of the East.
The West is slowly becoming aware of these practices and adopting them as their functional importance becomes evident, aside from Eastern dogma used for millenia to protect and encourage strict adherence in teaching to tradition (the intent of this dogmatic teaching is to keep these techniques pure..of course, they have varied, and these specialized variations have become "Schools" of Eastern philosophical beliefs and innovative technical practices, including martial arts, meditative methods, chircopractic and alignment science, and herbal/native plant based medicine).
We are not toys of nature, Hybah.
We are nature.
As are all living things, we are plastic in our functional (pheonotypic) expression, and therefore, we have a heretofore unrecognized (in the West) power and control over this gene expression. Proscribed by daily habit. Expression that can be guided within the span of our lives - not over many many generations, as previously thought. That is the beauty behind the emerging information on nuclear receptor molecular chemistry.
Control of plastic expression capacity, sir, is what these holistic practices of the East do - they maintain plastic response of genes to environmental conditions within specific norms - that is, to keep within a range of normalized functional expression OR restraint of gene expression, as is the case with oncogenes and other expression control elements that are part of the mechanisms of gene expression plasticity.
The reason for this plasticity capacity?
Simple. Its the primary mechanism of adaptive survival which has guided the evolutionary development of life on Earth for approximately 3.5-4 billion years.
Let that plastic capcity slip out of line, slip the bounds of normal control, and you have hyper-expression of proteins and structural elements and fast cell division and turnover.
Thats degenerative/proliferative disease and cancer, respectively. The rest of the molecular fuckups can be straightforwardedly attributed to a lack of control of oxidative stress damage.
A very simple equation, when the confounding details are set aside.
With the toy&nature thing I meant that we are what we are just because of genetics and external influences. Our freedom from not being total toys, lies in the abbility to logicaly evaluate the possible outcome of a future situation. The more free we are the more effective is the outcome of our future steps. We can take reasonable steps in future without having previous experience with it. But still there had to be something in our life (external influence) that taugh us to think like this. So we are complete fakes. I can take to look at myself like a "fake". My to a certain degree independent will was also simply shaped by genetics and external influences. If it weren't for those factors I would never be the one who I am. The problem with the feeling of "fake" is that i'm not sure if it's just my "positive mirage" or it comes from nature itself. A mechanism that helps us give us ego.
Somehow people are trying to be gods, to be foolishly independent. They even break the rules of instincts. They act the thing instinct made them to do but disobey the rules of the instinct itself. When they hit problems they do seem helpless. Like I was with my health problems. But still the mind is level 2 of nature and that means subordinate of the nature. Nature designed us.. we haven't yet completly designed ourselves.. it's going to be possible in the far future ... to design our instincts.. but when we finaly do it.. we still have to go along certain rules. Physical laws. They seem to have a logical sense too just as nature does. Even if we will be able to create a smaller universe with physical laws that are different. We still have to use the power of this universe to create it. And that again is somehow fake.
So again we're still the ones who have to follow something. Subordinates, toys, children.. name it as you will. This feeling is a burden and a gift at the same time. But more of a gift than a burden. It's a burden to the foolish ones and the ticket to freedom for the smart ones.
banana potassium - Google that and you'll see all about bananas.
When i was a kid and my parents took me sleigh riding, everytime we broke for lunch they fed me a banana. I always got a terrible stomach ache when we went sleigh riding. Years later i put 2&2 together and learned bananas give me a bad stomach ache.
Now being im trying hard to get strong again, looks like its time to start eating a lil every day and hope i can get used to them. My aunt has same problem.
My pops is 72, can outwork a 18 yr old, left puddles of sweat every day while working outside down here (florida) and the guy cant live without a fruit bowl on the counter stocked. Time for me to pick up those habbits.
Two potential culprits, one is a latex type compound. If you've ever had a banana tree as a houseplant, you know that it exudes a white latex material the plant tissue is damaged (say, a leaf is removed).
The other potential allergen is a lectin that is particular to bananas. People who have gluten allergies are allergic to lectins, a structural protein class found in most grains, some vegetables and many condiments and oils.
Folk who have problems with carbs in their diets (say, more than 200g) causing bloating and indigestion often have lectin or gluten allergies, sometimes allergies to casein as well.