as for physiological effects... I don't really know .
I have read that a splenda packet is roughly the equivalent of one gram of sugar, so if you use a shit load, it would probably have an effect... I don't really know how significant though.
That stuff is crap and can actually have the opposite effect. Your eyes just told your system 'sweet food', your nose just told your system 'sweet food', your tastebuds etc just told your system 'sweet food'.
So where's the &%$&$$ sweet food?
You just geared your body up for sugar that isn't there.
Seriously, just looking at food can trigger physiological reactions. On the occasional basis something like that won't do much harm but if anything you're likely to get fatter using that stuff. That's actually a patented technique to make lab rats fat; give em large doses of aspartame.
There's a lot of peeps out there that say it damages the part of the brain that regulates hunger. That certainly seems to be the case with mega-doses on rats but I've heard of at least one study that found such 'slimming' products make people fatter. I'll find a link, 'old up..
Calorie-conscious consumers who opt for diet sodas may gain more weight than if they drank sugary drinks because of artificial sweeteners contained in the diet sodas, according to a new study.
A Purdue University study released Sunday in the journal Behavioral Neuroscience reported that rats on diets containing the artificial sweetener saccharin gained more weight than rats given sugary food, casting doubt on the benefits of low-calorie sweeteners.
"There's something about diet foods that changes your metabolic limit, your brain chemistry," said ABC News' medical contributor Dr. Marie Savard.
Though Savard said more research needs to be done to uncover more information, the study does hint at the idea that the sweeteners alter a person's metabolism.
Savard said another recent study, which included more than 18,000 people, found healthy adults who consumed at least one diet drink a day could increase their chance for weight gain.
In the Purdue study, the rats whose diets contained artificial sweeteners appeared to experience a physiological connection between sweet tastes and calories, which drove them to overeat.
"The taste buds taste sweet, but there's no calorie load that comes with it. There's a mismatch here. It seems it changes your brain chemistry in some way," Savard said. "Anything you put in your mouth, your body has a strong reaction to it. It's much more than counting calories. It seems normally with sweet foods that we rev up our metabolism."