Omega 6 is in olive oil, avocados, natural peanut butter, raw nuts... no need to supplement with it.
Omega 3 on the other hand, is important. Flax oil has it, but the body must first convert it into EPA and then DHA. This conversion is dependent upon an enzyme - delta 6 desaturase - and this conversion process pretty much sucks, particularly for males and for older females. Estrogen seems to be a mitigating factor. For me, beyond this point there be dragons, but I do know that the EPA/DHA in fish oil is bioavailable so that's why I consume 10g fish oil daily, for the 3g combined EPA/DHA the AHA suggests is safe to take without a doctor's supervision.
Outside of this, I tend to avoid PUFAs, as they tend to promote inflammation in the body.
So no safflower oil for me, thanks. I'll stick with butter, egg yolks, avocados, olive oil, nuts...