Dave, Charles Staley talks a lot about the preference towards multiple sets. I think his materials can answer your question. Check www.integratedsportsolutions.com.
As I remember, 1 set with maximum intensity is enough to recruit much muscle fibers, but is not enough to fatique them all and trigger hyperthrophy. It's not enough to just recruit the fibers, you also need to recruit them a number of times to affect hyperthrophy (thus multiple sets). I am sure others can explain better.
- Josh



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