Despite having little to no knowledge on this, with regard to science, I still would not run on an empty stomach (2). I also do not believe there is much impact on which time of the day you choose to run (3).
I know in the mornings your cortisol levels are at their highest, unless of course you exercise that day for hours. On an empty stomach, after you body has not had anything to digest for 7+ hours, the enviroment is catabolic. Sure fat will be burned quicker through oxidative sources, as there are no carbs there to burn, but the hard earned muscle you have worked for will deteriorate nearly at the same rate. You will also likely feel like shit. At least IMO. Exercising without fuel is like trying to study after staying awake for 2 days straight...
I would think that running in the AM/PM doesn't really madder. Once you begin at a certain time of the day, you tend to get used to it.. at least I do. Depending on your lifestyle, you might like the AM better. After work, you could be exhausted and ready for a nap. Not a good running mood!



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