Once I did a 50 rep squat set. I didn't get that sore the next day, but it peaked by the third day and I had the same thing you describe. My quads sometimes just would not fire. My knees would buckle when I was walking and I almost fell over ~10 times that day, sometimes just standing. I did fall over once.
If the soreness is that bad I may take the day off, it is really up to you though. Sometimes the soreness is so bad it makes it hard to maintain form, especially when the muscles are not firing properly. On the same note, you may want to continue training to adapt to that sort of situation better in the future. It is up to you. You could do a combination and train lighter for that one day.
Oh yeah, I am not certain, but I find that when I stretch heavily after a workout it increases DOMS. That is just my personal experience.



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And I didn't do step-ups that workout I skipped them just because I had done a leg workout 2 days before. It was a good thing I was the only one working out that day, everyone else had basketball games.

