The one word that would describe Proviron is "unique." Proviron is an oral anabolic steroid of the generic compound mesterolone , but behaves as an anti-aromatase agent Thus, Proviron is classified as an androgenic steroid and anti-aromatization prescription drug.
Speculations abound on how Proviron exerts this activity. Some steroid experts say it may be attributed to estrogen receptor downregulation. There is a generally accepted theory, however, which says that Proviron's anti-estrogenic characteristics are due to its ability to prevent the production of estrogens . And since Proviron is considered a weak anabolic, it is more popular for its ability to prevent gyno and fluid retention. In fact, if you're to take a look at Proviron's history you'd know that this has always been the case with Proviron. Bodybuilders during the 1970s to 1980s used Proviron mostly for its anti-aromatase properties. Drugs like Arimidex and Aromasin were not yet available at that time.
Proviron binds well with androgen receptors, but it has also strong affinity for the hydroxysteroid dehydrogenase (3HSD), an enzyme that downgrades steroids by removing their 3-keto group. This is the reason why this steroid displays weak anabolic effects.
Proviron , however, is well known as a "helper" steroid. This compound has high affinity for the sex hormone-binding globulin (SHBG), which is why it is often stacked in a cycle to potentiate the efficacy of the other steroids being used. SHBG, particularly those produced by the testes, have high affinity for androgens thus they are sometimes called androgen-binding protein. Consequently, when Proviron binds with SHBG, androgens are free to exert their anabolic effects.
Proviron is preferred in a cycle wherein highly aromatizable agents are used. Aromatizable drugs are notorious for causing excessive water retention and gynecomastia. Proviron is also used post cycle since it is effective in inhibiting the activity, as well as preventing the production of estrogen. Remember that even when you stop taking exogenous androgens, aka steroids, your body is still unable to produce its own androgens. As such, there are more circulating estrogens in your body than androgens. This is why Proviron is also a good drug to use in post-cycle therapy as it can hasten sperm production to restore sexual functions.
This is not to say, however, that estrogen is the baddest of all hormones. This hormone is also necessary for muscle growth to occur. A moderately elevated estrogen level is, in fact, much desired by bodybuilders who are after a more pronounced muscle mass. And it is not only estrogen that can cause gynecomastia and fluid retention; progestin can also exhibit side effects similar to those observed with excessive estrogen level.
The most common complaint with Proviron by male users is erectile dysfunction, specifically prolonged and frequent erections. The potential side effect for female users with Proviron use is disruption of menstrual cycles.
Liver damage, the most talked-about side effect of steroid use, will not be a problem with Proviron since it has not been modified at the 4th ring; meaning, it is not alpha-alkylated. Most orals have this alteration for them to survive the first-pass metabolism.
Recommended daily dosage of Proviron is 25mg-200mg daily for males and 25mg-50mg for females.*