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12-23-2010, 09:45 AM

Tadalafil Citrate

What Is Cialis (Tadalafil)

Cialis is a brand name for a substance with the chemical name tadalafil. It is used to treat men who experience difficulty having and maintaining an erection to orgasm.

It was first introduced in February 2003 and it was approved by the FDA on November 21, 2003. Cialis was first marketed by Lilly ICOS, a joint venture between Eli Lilly and ICOS Corporation.

The standard starting dose size is 10 milligrams. In some cases a 20 milligram dose is necessary. Cialis should be taken orally 30 minutes or longer before sexual activity.

Medical testing has shown that cialis is effective in 60%-80%, of cases when used to treat erectile dysfunction in men. Most failure cases are from men that have had some form of surgery that made getting or maintaining an erection physically impossible. During PCT a man may find it more difficult to have or maintain an erection so Cialis is a possible solution to that problem.

Cialis produces results similar to viagra, but the effects of cialis last longer than viagra. In addition, cialis can be taken on an empty stomach or with a meal. When Cialis and Viagra were compared in a study Cialis allowed for more sexual frequency and that in turn raised Testosterone levels higher in the Cialis group.

Viagra should not be taken with high fat foods because these foods reduce absorption of viagra in the human body. Cialis on the other hand may be used even when dining on high fat foods, with no decrease in effects.

How Does Cialis Work

Medications like cialis, viagra, and levitra work by inhibiting a chemical called phosphodiesterase type 5. Because of their mode of action, these drugs are commonly referred to simply as PDE5 inhibitors.

When a man gets sexually excited, it triggers cells in the penis to produce nitric oxide. The increase in nitric oxide will in turn cause production of cyclic guanosine monophosphate (cGMP). The cGMP causes arteries in part of the penis to relax and allow more blood to flow through them. The increase in blood flow causes an erection.

If the enzyme phosphodiesterase type 5 (PDE5) is of sufficient quantity, it will attack the cGMP and erection will not be maintained. Cialis and other PDE5 inhibitors reduce the amount of PDE5 available to attack cGMP. With a reduction of PDE5, most men are able to maintain an erection to orgasm.

How Long Do the Effects of Cialis Last

The effects of cialis have been shown to last 24 to 36 hours in a majority of users. The effects of viagra have been shown to last 4 to 6 hours in a majority of users.

Some men like the fact that cialis works for up to 36 hours and allows the user and his partner to relax, forget about planning intimacy and let things happen when the moment is right.

24 to 36 hours might seem ideal but some men report they switched back to viagra because 6 hours or less was what they preferred. I have personally have had good results from Cialis anywhere from 1-36 hours after taking it but 24 hours seems to be a peak time for me.

Taking cialis does not increase sexual desire directly and it will not give you an erection for 36 hours. Most men who take cialis report that for up to 36 hours after taking cialis, an erection can be sustained when the penis was stimulated by touch. After orgasm, the penis will usually return to its pre-aroused state.

Some men may be able to have one or more orgasms after the first but this an exception. In most cases, within 36 hours of taking 20 milligrams of cialis, you will be able to get and maintain an erection to orgasm one time.

Most men that have had more than one orgasm from a single dose say they had the first orgasm within 60-180 minutes of taking cialis then were able to have one or more orgasms by waiting 60 minutes or longer before any more penis stimulation was attempted. This is something the user will have to experiment with to find out their own particular climax capacity.

12-23-2010, 09:47 AM
Cialis vs. Viagra

Cialis (Tadalifil citrate) is the second-generation Viagra, more or less. While the little blue pill may work to give you an erection for 6-8 hours, Cialis is good for 36-48 hours. This obviously makes it much more practical. Why are we talking about this? Well I doubt anyone using endogenous testosterone would need to consider the use of such a compound, this drug can still have some uses during post-cycle therapy. A lot of men find that once they go off steroids and begin post cycle therapy (PCT), they suffer reduced libido as well as erectile dysfunction. Well, Cialis may be useful for helping this, at least during PCT.

The efficacy and safety of Tadalafil for the treatment of erectile dysfunction was assessed in a 6-month study. Men with mild, moderate or severe ED were given tadalafil (20 mg) as needed or placebo ("any minute now, baby no, really& ").

Tadalafil significantly improved erectile function compared with placebo (which only succeeded in embarrassing the men who took it and tried to get laid). At the end of the study, sexual intercourse attempts success rate for those using Cialis was 73.5% (this only refers to the ability to achieve erection and have intercourse, not the actual success rate of those attempting to get laid on a given night)(1).

Cialis Side Effects

Of particular interest to those considering the use of Cialis is that Lack of sexual activity due to erectile dysfunction actually decreases testosterone (T) levels through a central effect on the hypothalamic-pituitary axis.(2) Cialis was given to men for a month, and at the end, they had considerably higher testosterone levels, because they got laid more(2), as it is unlikely that the drug has a different direct effect on the pituitary-testis axis.

This stuff is actually very safe, and was even given 3x a week to men (1) for an extended length of time, and was well tolerated, had very few sides, and was very effective (1). Thus, it could be another potential compound for inclusion in PCT. Tadalafil (20 mg) significantly improves erectile function, could increase testosterone, and is well tolerated (3), certainly something to think about after your next cycle.

A 6-month study of the efficacy and safety of tadalafil in the treatment of erectile dysfunction: a randomised, double-blind, parallel-group, placebo-controlled study in Australian men. Int J Clin Pract. 2005 Feb;59(2):143-9.
Type V phosphodiesterase inhibitor treatments for erectile dysfunction increase testosterone levels. Clin Endocrinol (Oxf). 2004 Sep;61(3):382-6.
Efficacy and treatment satisfaction with on-demand tadalafil (Cialis) in men with erectile dysfunction. Eur Urol. 2004 Sep;46(3):362-9; discussion 369.

12-23-2010, 09:48 AM
Cialis outperforms Viagra in sexual frequency and in raising testosterone.

Type V phosphodiesterase inhibitor treatments for erectile dysfunction increase testosterone levels.

Carosa E (http://forums.rxmuscle.com/pubmed?term=%22Carosa%20E%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_RVAbstract), Martini P (http://forums.rxmuscle.com/pubmed?term=%22Martini%20P%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_RVAbstract), Brandetti F (http://forums.rxmuscle.com/pubmed?term=%22Brandetti%20F%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_RVAbstract), Di Stasi SM (http://forums.rxmuscle.com/pubmed?term=%22Di%20Stasi%20SM%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_RVAbstract), Lombardo F (http://forums.rxmuscle.com/pubmed?term=%22Lombardo%20F%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_RVAbstract), Lenzi A (http://forums.rxmuscle.com/pubmed?term=%22Lenzi%20A%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_RVAbstract), Jannini EA (http://forums.rxmuscle.com/pubmed?term=%22Jannini%20EA%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_RVAbstract).
Department of Experimental Medicine, University of L'Aquila, L'Aquila, Italy.

OBJECTIVE: Lack of sexual activity due to erectile dysfunction (ED) decreases testosterone (T) levels through a central effect on the hypothalamic-pituitary axis. In this paper we studied the effect of different type V phosphodiesterase (PDE5) inhibitor treatments for ED on the reversibility of this endocrine pattern. DESIGN: Open-label, retrospective study. PATIENTS: Seventy-four consecutive patients were treated on demand with sildenafil (Sild) (50 mg) and tadalafil (Tad) 20 mg. MEASUREMENTS: The success in sexual intercourse was recorded and total (tT) and free testosterone (fT) levels were studied before and after 3 months of treatment. RESULTS: Basal level of tT and fT were at the bottom of the normal range and LH levels were at the top of the high normal range. After treatments, this endocrine pattern was reversed in both groups. However, the T increase in Sild-treated patients was significantly lower than in those treated with Tad (4.7 +/- 2.7 vs. 5.1 +/- 0.9, P < 0.001). fT levels followed a directly proportional pattern, while the inverse was found when LH production was studied. The intercourse rate reflected this effect: in fact, the Sild group showed a 4.9 +/- 2.9/month full sexual intercourse rate while in the Tad group a significantly higher rate of sexual intercourse was found (6.9 +/- 4.6/month, P = 0.04). However, drug consumption was comparable between the groups (Sild 4.9 +/- 2.9 vs. Tad 4.4 +/- 2.8 pills/month, P = 0.72). CONCLUSIONS: As it is unlikely that the two drugs have a different direct effect on the pituitary-testis axis, this effect is probably due to the higher frequency of full sexual intercourse in the Tad-treated group, because of the drug's longer half-life.

PMID: 15355456 [PubMed - indexed for MEDLINE]

12-23-2010, 09:48 AM
Five-year experience with tadalafil in the UK: an effective treatment for erectile dysfunction.

Dinsmore W (http://forums.rxmuscle.com/pubmed?term=%22Dinsmore%20W%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_RVAbstract).
Royal Victoria Hospital, Grosvenor Road, Belfast, UK. wallace.dinsmore@royalhospitals.n-i.nhs.uk (wallace.dinsmore@royalhospitals.n-i.nhs.uk)

BACKGROUND: Erectile dysfunction (ED) is a common medical condition. In the UK, approximately 2.3 million men suffer from moderate-to-severe ED, many of whom do not consult a healthcare professional about the problem. Phosphodiesterase-type 5 (PDE5) inhibitors have revolutionised treatment for ED and three such drugs are currently available: sildenafil citrate, tadalafil and vardenafil HCl. METHODS: This article reviews available information on the efficacy and safety of tadalafil for the treatment of ED, with a focus on clinical experience in the UK. RESULTS: The clinical effects of tadalafil have been shown to last for up to 36 h after administration, longer than the other PDE5 inhibitors, which are effective for only 4-5 h after dosing. Extensive clinical experience with tadalafil, worldwide and in the UK, supports its efficacy and tolerability in many patient populations, including those with comorbidities often associated with ED. CONCLUSIONS: Studies have shown that tadalafil is an effective ED treatment, regardless of disease severity and cause, patient age and presence of comorbid conditions. As the treatments for ED have evolved, patient preference has emerged as an important aspect of ED therapy.

PMID: 19624790 [PubMed - in process]

12-23-2010, 09:49 AM
A 6-month study of the efficacy and safety of tadalafil in the treatment of erectile dysfunction: a randomised, double-blind, parallel-group, placebo-controlled study in Australian men.

McMahon CG (http://forums.rxmuscle.com/pubmed?term=%22McMahon%20CG%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_RVAbstract), Stuckey BG (http://forums.rxmuscle.com/pubmed?term=%22Stuckey%20BG%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_RVAbstract), Lording DW (http://forums.rxmuscle.com/pubmed?term=%22Lording%20DW%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_RVAbstract), Wittert GA (http://forums.rxmuscle.com/pubmed?term=%22Wittert%20GA%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_RVAbstract), Murphy A (http://forums.rxmuscle.com/pubmed?term=%22Murphy%20A%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_RVAbstract), Shin J (http://forums.rxmuscle.com/pubmed?term=%22Shin%20J%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_RVAbstract), Sutherland PD (http://forums.rxmuscle.com/pubmed?term=%22Sutherland%20PD%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_RVAbstract), Palmer NR (http://forums.rxmuscle.com/pubmed?term=%22Palmer%20NR%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_RVAbstract), Lowy MP (http://forums.rxmuscle.com/pubmed?term=%22Lowy%20MP%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_RVAbstract), Jesudason DR (http://forums.rxmuscle.com/pubmed?term=%22Jesudason%20DR%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_RVAbstract), Fredlund P (http://forums.rxmuscle.com/pubmed?term=%22Fredlund%20P%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_RVAbstract).
Australian Centre for Sexual Health, St Leonards, Sydney, New South Wales 2011, Australia. cmcmahon@acsh.com.au (cmcmahon@acsh.com.au)

The efficacy and safety of tadalafil for the treatment of erectile dysfunction (ED) were assessed in a 6-month, randomised, double-blind, placebo-controlled study. Australian men with mild, moderate or severe ED of organic, psychogenic or mixed aetiology were randomised to tadalafil 20 mg as needed (n = 93) or placebo (n = 47). Efficacy assessments included the international index of erectile function (IIEF) and the sexual encounter profile (SEP) diary. Tadalafil significantly improved erectile function compared with placebo (p < 0.001, all measures). At the end of the study, the mean per-patient proportion of successful sexual intercourse attempts (SEP question three) was 73.5% for patients treated with tadalafil and 26.8% for placebo-treated patients. Improved erections were reported by 78% of tadalafil-treated patients compared to 12.8% of placebo-treated patients. The most common treatment-emergent adverse events--headache and dyspepsia--were generally mild or moderate. Tadalafil was effective and well tolerated in Australian men with mild to severe ED.

PMID: 15854188 [PubMed - indexed for MEDLINE]

07-01-2013, 05:09 PM
J Am Coll Cardiol. (http://www.ncbi.nlm.nih.gov/pubmed/22818063#) 2012 Aug 21;60(8):768-74. doi: 10.1016/j.jacc.2012.05.004. Epub 2012 Jul 18.

Tadalafil for the treatment of pulmonary arterial hypertension: a double-blind 52-week uncontrolled extension study.

Oudiz RJ (http://www.ncbi.nlm.nih.gov/pubmed?term=Oudiz%20RJ%5BAuthor%5D&cauthor=true&cauthor_uid=22818063), Brundage BH (http://www.ncbi.nlm.nih.gov/pubmed?term=Brundage%20BH%5BAuthor%5D&cauthor=true&cauthor_uid=22818063), Gali? N (http://www.ncbi.nlm.nih.gov/pubmed?term=Gali%C3%A8%20N%5BAuthor%5D&cauthor=true&cauthor_uid=22818063), Ghofrani HA (http://www.ncbi.nlm.nih.gov/pubmed?term=Ghofrani%20HA%5BAuthor%5D&cauthor=true&cauthor_uid=22818063), Simonneau G (http://www.ncbi.nlm.nih.gov/pubmed?term=Simonneau%20G%5BAuthor%5D&cauthor=true&cauthor_uid=22818063), Botros FT (http://www.ncbi.nlm.nih.gov/pubmed?term=Botros%20FT%5BAuthor%5D&cauthor=true&cauthor_uid=22818063), Chan M (http://www.ncbi.nlm.nih.gov/pubmed?term=Chan%20M%5BAuthor%5D&cauthor=true&cauthor_uid=22818063), Beardsworth A (http://www.ncbi.nlm.nih.gov/pubmed?term=Beardsworth%20A%5BAuthor%5D&cauthor=true&cauthor_uid=22818063), Barst RJ (http://www.ncbi.nlm.nih.gov/pubmed?term=Barst%20RJ%5BAuthor%5D&cauthor=true&cauthor_uid=22818063); PHIRST Study Group (http://www.ncbi.nlm.nih.gov/pubmed?term=PHIRST%20Study%20Group%5BCorporate%20A uthor%5D).

Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA. roudiz@labiomed.org


The aim of this study was to evaluate the long-term safety and durability of efficacy of tadalafil for pulmonary arterial hypertension.

Tadalafil is an oral phosphodiesterase-5 inhibitor approved for PAH treatment. In the multicenter, placebo-controlled, randomized, 16-week PHIRST (Pulmonary Arterial Hypertension and Response to Tadalafil) study, tadalafil 40 mg improved exercise capacity and delayed clinical worsening.

Eligible patients from PHIRST received once-daily tadalafil 20 mg (T20 mg) or 40 mg (T40 mg) (n = 357) in the double-blind, 52-week, uncontrolled extension study (PHIRST-2); 293 patients completed PHIRST-2. Durability of efficacy was explored using the 6-min walk distance (6MWD) test. Clinical worsening and changes in World Health Organization functional class were evaluated.

The safety profile of tadalafil in PHIRST-2 was similar to that in PHIRST, with typical phosphodiesterase-5 inhibitor adverse events. The 6MWDs achieved in PHIRST for the subset of patients receiving T20 mg and T40 mg in both PHIRST and PHIRST-2 (406 ? 67 m [n = 52] and 413 ? 81 m [n = 59] at PHIRST-2 enrollment, respectively) were maintained at PHIRST-2 completion (415 ? 80 m [n = 51] and 410 ? 78 m [n = 59], respectively). Numerically fewer patients who were on T40 mg in PHIRST and PHIRST-2 experienced World Health Organization functional class deterioration (6% [n = 5]) compared with those randomized to T20 mg (9% [n = 7]) across both studies. Post hoc analyses showed that background bosentan use and higher 6MWD at PHIRST baseline were associated with fewer clinical worsening events.

Long-term treatment with tadalafil was well tolerated in patients with pulmonary arterial hypertension. In patients receiving either T20 mg or T40 mg, the improvements in 6MWD demonstrated in the 16-week PHIRST study appeared sustained for up to 52 additional weeks of treatment in PHIRST-2. (Pulmonary Arterial Hypertension and Response to Tadalafil Study; NCT00549302).

Copyright 2012 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

PMID: 22818063 [PubMed - indexed for MEDLINE]

07-06-2013, 12:39 PM
Cialis is also very effective for bph....and ED and BPH are both found in many men...

Kill two birds with one stone...

In research the Cialis from Purchase Peptides even at just 5mg was found effective...