Anyone tried the HGH frag 176-191? I've had some from naps for around 6+ months and haven't used it yet because the reviews are so hard to find. Any new info would be appreciated
I have no experience with hGH Frag 176 191 however, it seem ( I wont say for sure as I have yet to verify this) that the Monash University, of Clayton, Victoria, Australiaid did a study of hGH frag 176 191 aka AOD9604. A portion follows and the link to where I found it is
HGH Fragment & little R&D
"OBJECTIVE: To observe the chronic effects of human growth hormone (hGH) and AOD9604 (a C-terminal fragment of hGH) on body weight, energy balance, and substrate oxidation rates in obese (ob/ob) and lean C57BL/6Jmice. In vitro assays were used to confirm whether the effects of AOD9604 are mediated through the hGH receptor, and if this peptide is capable of cell proliferation via the hGH receptor."
"RESULTS: Both hGH and AOD significantly reduced body weight gain in obese mice. This was associated with increased in vivo fat oxidation and increased plasma glycerol levels (an index of lipolysis). Unlike hGH, however, AOD9604 did not induce hyperglycaemia or reduce insulin secretion. AOD9604 does not compete for the hGH receptor and nor does it induce cell proliferation, unlike hGH.
CONCLUSIONS: Both hGH and its C-terminal fragment reduce body weight gain, increase fat oxidation, and stimulate lipolysis in obese mice, yet AOD9604 does not interact with the hGH receptor. Thus, the concept of hGH behaving as a pro-hormone is further confirmed. This data shows that fragments of hGH can act in a manner novel to traditional hGH-stimulated pathways."
"...We have also examined the ability of AOD9604 to act through the hGH receptor in vitro, and shown that there is no competition between AOD9604 and 125I-hGH for this receptor. In addition, we have found that AOD9604 is incapable of inducing cell proliferation via the hGH receptor, a response that hGH induces with high potency. Together this data suggests that this new analogue of an hGH fragment, has similar actions on lipid metabolism to hGH, yet works independently to hGH on carbohydrate metabolism, receptor recognition, and cell proliferation. Hence, AOD9604 is a novel peptide, which works through its own effector-mediated pathway to induce some of the lipid mobilizing effects performed by the parent hormone , hGH. Our data provides strong support for the concept that hGH's diverse functions are mediated by specific domains of the hormone , and raises the possibility that some of these domains may have potential in the treatment of obesity.
Chronic administration of both hGH and AOD9604 blunts weight gain and reduces fat mass in obese (ob/ob) mice.14,20 Although we have previously shown an acute stimulatory effect of AOD9604 on resting energy expenditure,12 we did not find a significant effect of chronic treatment of AOD9604 on resting energy expenditure in the present study even when we examined this data as a change from pre-treatment. From these observations, we may conclude that AOD9604 exerts acute stimulatory effects on fat and glucose oxidation and energy expenditure, whereas chronic treatment increases fat oxidation alone. The differences may be attributed to duration and mode of administration of AOD9604.
The effect of AOD9604 and hGH on adiposity also does not appear to be mediated by a reduction in caloric intake. The decrease in body fat is, however, associated with a marked increase in fat oxidation and, based on the circulating glycerol levels, a marked increase in lipolysis. The increases in fat oxidation in lean mice were much smaller than observed in the obese mice, and had no significant impact on body weight, presumably because there is less adipose tissue for the compounds to target in the lean mice. It should also be noted that the leptin-deficient ob/ob mouse has an inherently low rate of fat oxidation (Table 1) which may make this animal more receptive to agents which promote fat oxidation.
The actions of hGH on adipocyte metabolism are varied, complex and not yet fully elucidated...."
It seems as if it will help burn adipos fat to some extent. It will not really build strength and size but help with some lean muscle.
EDIT: I am looking into this a lot in the last few minutes. I was planing on trying HGH but am now leaning towards getting some ADO instead. It seems that it may be quite a good thing.
