Super-DMZ rx~Dimethazine (updated 2011)

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    Super-DMZ rx~Dimethazine (updated 2011)

    Super-DMZ rx by heavyiron

    Super-DMZ rx
    , is an over the counter legal product that contains 10mg of Superdrol and 10mg of Dimethazine per capsule. Dimethazine is two steroid molecules bound together by a nitrogen atom. Upon ingestion, stomach acid separates the two steroid molecules that closely resemble methyldrostanolone (Superdrol) Therefore Super DMZ contains both Superdrol and Dimethazine. Dimethazine once broken down is similar to Superdrol though.

    Dimethazine was a prescribed steroid at one time therefore we have human trials in which this steroid was used. This medication has been around since 1962 when it was presented in the literature. Early on it was sold under the Roxilon brand name. Dimethazine is basically an oral Masterone (drostanolone propionate). Published reports indicate that Dimethazine possesses an androgenic rating of 96 and an anabolic rating of 210. Furthermore it seems to possess little to no estrogenic or progestational activity. The reason I feel this is not identical to Superdrol is because Superdrol has a different androgenic/anabolic rating of 20/400 respectively. However Dimethazine is a strong steroid on its own. The addition of Superdrol makes Super DMZ rx an even stronger steroid.

    Dimethazine is an oral c-17alpha alkylated steroid that is liver toxic to a degree. Note that in studies administering 20mg daily to female patients for 45-95 days, dimethazine was shown to induce modest to moderate bilirubinemia (excess bilirubin in the blood, indicative of hepatic stress) in close to 50% of patients. Approximately 25% of the patients noticed substantial increases in serum transaminases. These results suggest this steroid has significant hepatoxicity and should therefore be limited to shorter durations of use. Superdrol is also known for hepatoxicity so care must be taken when using Super DMZ rx.

    Super DMZ is a potent oral steroid that should illicit solid gains in lean body mass with little water or fat gain depending on diet. Most users can tolerate between 20-40 mg (1-2 capsules) daily for 4-6 weeks however more adventuresome users may use up to 60mg (3 capsules) daily for shorter durations like 2-3 weeks. What struck me the most about this steroid is how rapid and dry my gains were. It reminded me of a faster acting, dryer Dianabol. However Super DMZ rx is much stronger mg for mg than Dianabol. Users of Super-DMZ can expect to add 8-12lbs of lean body mass in just 3-4 weeks. I personally had no noticable side effects from Super-DMZ at 2 capsules daily for 4 weeks. Super DMZ rx is a strong, clean steroid that can be used to increase lean mass, strength and power with little to no water retention in short periods of time.

    Lipid and Organ Support

    Because of the liver toxicity of Super DMZ rx I strongly recommend using liver supporting supplements such as ADVANCED CYCLE SUPPORT™ - Complete 'On Cycle' Prohormone Support and/or Liv 52 before and during administration of this designer steroid. Proper hydration is also recommended to lower stress on organs. Alcohol and other liver stressing medications like acetaminophen should be avoided during Super DMZ administration. Oral steroids often times negatively affect lipids therefore lipid supporting supplements should also be employed such as omega 3 fish oils, fiber and plant sterols. High blood pressure is another concern so that should be monitored regularly. Consult your health care professional before using any dietary supplements.

    Post Cycle Therapy

    Since Super DMZ rx will cause interruption of the
    Hypothalamic-Pituitary-Testicular Axis, post cycle therapy is strongly recommended. Bulbine natalensis or ProLensis™ is a amazing over the counter testosterone recovery supplement. It stimulates the production of GNRH and also increases cholesterol in the testes. Prolensis causes production of LH, which in turn signals the testis to produce testosterone. Evidence shows that ProLensis™ can stimulate LH 169% compared to study controls. Research further shows Testosterone is boosted a whopping 347%! This natural compound is a main ingredient in IronMagLabs Bodybuilding Supplements & Prohormones: Ultra Male Rx. Ultra male Rx also has pro sexual effects as well as boosting Testosterone. Some Testosterone boosting compounds may increase Estrogen but in rodent studies it was confirmed the the main ingredient in Ultra Male Rx actually decreases Estrogen by 35%. Ultra Male Rx is a legal way to significantly boost testosterone, control Estrogen and raise libido.

    Sample Cycle

    Weeks 1-4 Super DMZ RX-2 capsules per day
    Weeks 1-8
    Advanced Cycle Support-2 capsules per day (organ and lipid support)
    Weeks 5-8
    Ultra Male RX-1 capsule per day (post Cycle Therapy)

    Super-DMZ rx is currently available for purchase without a prescription. Super-DMZ Rx™ Pro-Anabolic (Superdrol Dymethazine)

    Chemical Name(s): Dimethazine

    17beta-hydroxy 2alpha,17alpha-dimethyl 5alpha-androstan 3-one azine


    Chemical Name(s): Superdrol
    2a,17a-dimethyl-5a-androst-3-one-17b-ol
    2a,17a-dimethyl-etiocholan-3-one-17b-ol



    Referrences


    1. Biological activity of dimethazine in the protein-anabolic field.

    2. Protracted action of protein anabolism in gynecological oncology and its effect on hepatic function.
    3. A new steroid with protein anabolic activity: dimethazine.
    4. Biological determination of the secondary hormonal activities of dimethazine.
    5. Antigonadotropic action of a new steroid with anabolizing activity studied in the anterior pituitary gland of the castrated rat
    6.
    Methasteron-Associated Cholestatic Liver Injury: Clinicopathologic Findings in 5 Cases”
    7.
    Anabolic and androgenic activities of Bulbine natalensis stem in male Wistar rats
    8. Effect of aqueous extract of Bulbine natalensis (Baker) stem on the sexual behaviour of male rats.
    Attached Images Attached Images
    Last edited by heavyiron; 12-29-2011 at 06:30 PM. Reason: 2011 update

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  2. #2
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    I found an old i-force article on the web with some interesting claims about Dymethazine.

    About Dymethazine:

    In only 4 years since the Pro-Hormone ban of 2005 countless products have claimed to be as strong as or even stronger than the over the counter hormones once sold. After considerable time, energy, and research performed by i-Force's product formulation team, we are proud to announce the hormonal product everyone has been waiting for.

    Featuring unheard of anabolic and myotropic effects, Dymethazine was compared to Methyltestosterone, Oxymethalone, Androstanazole and Testosterone Propionate in their protein-anabolic activity. Dymethazine was shown to have the HIGHEST myotropic (muscle building) effects out of any of the previously named steroids (Methyl-Test, Anadrol, Winstrol, and Testosterone Propionate)! In addition to this, it also displayed an ability to induce a higher rate of Nitrogen retention than Methyl-Test.(1)

    In another study performed on Dymethazine, patients were administered Dymethazine for 45+ days. Liver values did not change for 50% of patients, while the other 50% noticed only modest to moderate increases in liver values(2). So, Dymethazine can increase liver values, however nowhere near the current methyl monsters on the market today. This means Dymethazine can be run for 4-6 weeks without the need of expensive liver support supplements.

    Hormonal products that give huge strength/weight gains are usually associated with watery or wet gains due to large amounts of aromatization resulting in high levels of estrogen in the body. Too much estrogen can cause severe bloating, fat gain, and even potential growth problems. Dymethazine features 0% ability to aromatize and expresses an extremely weak androgenic activity (3). This means Dymethazine will produce intense gain, has very little to no liver impact, and will cause absolutely no estrogen related side effects.

    Move beyond the pro-hormones of yesterday, and step into the future of Designer Steroids with Dymethazine. Consume 1-3 capsules, evenly spaced throughout the day. Do not use Dymethazine for longer than 6 weeks. Immediately begin PCT dosing protocol upon finishing Dymethazine. Wait at least 90 days before running Dymethazine again.

    Referrences

    1. Biological activity of dimethazine in the protein-anabolic field. Matscher, R.; Lupo, C.; De, P. Ruggieri. Lab. Ric. Ormonoter. Richter, Milan, Bollettino - Societa Italiana di Biologia Sperimentale (1962), 38 988-90. CODEN: BSIBAC ISSN: 0037-8771. Journal language unavailable. CAN 58:34623 AN 1963:34623 CAPLUS
    2. Protracted action of protein anabolism in gynecological oncology and its effect on hepatic function. Dambrosio, F.; Donatelli, G. Fontana. Univ. Milan, Cancro, Il (1963), 16(5), 553-604. Journal language unavailable. CAN 62:11656 AN 1965:11656 CAPLUS
    3. A new steroid with protein anabolic activity: dimethazine. De Ruggieri, P.; Matscher, R.; Gandolfi, C.; Chiaramonti, D.; Lupo, C.; Pietra, E.; Cavalli, R. Ormonoterap. Richter, Milan, Archivio di Scienze Biologiche (Bologna) (1963), 47(1), 1-19. CODEN: ASBIAL ISSN: 0004-0169. Journal language unavailable. CAN 60:46973 AN 1964:46973 CAPLUS

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  3. #3
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    Comparisons with methyltest, winny, anadrol and test prop showed better mytropic effect (muscle building) on the castrates with Dimethazine. In other words, mg for mg Dimethazine outperformed the above listed steroids for building muscle.

    Biological activity of dimethazine in the protein-anabolic field.

    Matscher, R.; Lupo, C.; De, P. Ruggieri. Lab. Ric. Ormonoter. Richter, Milan, Bollettino - Societa Italiana di Biologia Sperimentale (1962), 38 988-90. CODEN: BSIBAC ISSN: 0037-8771. Journal language unavailable. CAN 58:34623 AN 1963:34623 CAPLUS

    Abstract

    Dimethazine (I), 2,17-dimethyl-5-androstan-17-ol-3,3'-azine, was compared to methyltestosterone, oxymethalone, androstanazole and testosterone propionate in its protein-anabolic activity. The tests were made on castrated rats with a single hypodermic injection of 250 , on young male and female rats with increasing daily oral doses from 100 to 1000 for 30 days, and on adult male rats with daily oral doses of 1000 for 25 days. It was shown that I did not interfere with the growth of young animals; that adult rats treated with I gained, on an av., 20 g. more in wt. than the controls; and that I had a greater myotropic effect on castrates than the other steroids, and induced a higher N retention than methyltestosterone in adult males.

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  4. #4
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    Here is an abstract where females took 20mg for 45+ days...and it appears that less than half had any liver issues.

    Protracted action of protein anabolism in gynecological oncology and its effect on hepatic function.

    Dambrosio, F.; Donatelli, G. Fontana. Univ. Milan, Cancro, Il (1963), 16(5), 553-604. Journal language unavailable. CAN 62:11656 AN 1965:11656 CAPLUS

    Abstract

    Twenty mg. of dimethazine, an anabolizing steroid, was administered daily for 45-95 days to 11 gynecological patients. More than 50% of the cases showed no change in the bilirubinemia, the others showed modest to moderate increases. The glutamic-oxalacetic and the glutamic-pyruvic transaminases of the serum increased greatly in 3 patients. The albumins concn. usually decreased in the course of the treatment, while the globulins concn. did not change.

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    This seems to support published reports that Dimethazine possesses a lower androgenic rating which would mean less androgenic sides and more anabolic muscle building effects.

    A new steroid with protein anabolic activity: dimethazine.

    De Ruggieri, P.; Matscher, R.; Gandolfi, C.; Chiaramonti, D.; Lupo, C.; Pietra, E.; Cavalli, R. Ormonoterap. Richter, Milan, Archivio di Scienze Biologiche (Bologna) (1963), 47(1), 1-19. CODEN: ASBIAL ISSN: 0004-0169. Journal language unavailable. CAN 60:46973 AN 1964:46973 CAPLUS

    Abstract

    Dimethazine (I) was evaluated for the following biol. activities: androgenic, N retaining, P retaining, and Ca retaining. The increase in uptake of -aminoisobutyric acid-1-14C and the increase in body wt. were also investigated. Data obtained, tabulated, and compared to those obtained with methyltestosterone established that I is a protein anabolic steroid with weak androgenic activity.

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    Little to no progestenic/estrogenic activity...

    Biological determination of the secondary hormonal activities of dimethazine.

    Lupo, C.; Matscher, R.; Ruggieri, P. De. Lab. Ric. Ormonoter. Richter, Milan., Bollettino - Societa Italiana di Biologia Sperimentale (1962), 38 990-4. CODEN: BSIBAC ISSN: 0037-8771. Journal language unavailable. CAN 58:34624 AN 1963:34624 CAPLUS

    Abstract

    Expts. with rats and rabbits showed that dimethazine, 2,17-dimethyl-5-androstan-17-ol-3,3'-azine has, in contrast to its protein-anabolic properties, practically no estrogenic, progestational, and corticoid activity. Similarly, it has no effect on liver glycogen, and no antiinflammatory action on the anaphylactoid edema.

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    Antigonadotropic action of a new steroid with anabolizing activity studied in the anterior pituitary gland of the castrated rat

    Author Beghelli, V.; Mavrulis, A. Organization Univ. Bologna, Italy Publication Source Biochimica Applicata (1962), 9(No. 4), 179-88 Identifier-CODEN BIALAY ISSN 0006-298

    Abstract:

    Seventy-five female rats were divided into 5 groups; 15 served as controls; 60 were castrated and among these, 15 were treated with 17.alpha.-ethyl-19-nortestosterone (I), 15 with 17.alpha.-methyl-17.beta.-hydroxyandrosta-1,4-dien-3-one (II), and 15 with 2.alpha.,(Dimethazine) (III). With each of these steroids, treatment began 48 hrs. after the operation, with 1 mg. of the drug suspended in 0.5 ml. of saline (1% Tween 80 as suspending agent) once daily for 20 days by gavage. The last 15 received the vehicle only, according to the same schedule. The rats were sacrificed 24 hrs. after the last dose, and their pituitary glands and uteri examined. The castrates which received the vehicle only showed very pronounced gonadotropic pituitary hyperfunction, such as formation of castration cells and an increase in basophilic cells. Animals treated with I showed no castration cells at all, and only a small increase in basophilic cells. Those given II had some castration cells, and only a moderate redn. of basophilic cells compared with the untreated rats. The effect of III on the pituitary was almost negligible. In uterotropic activity, measured as the ratio of uterus wt. to body wt., I was most effective; III was intermediate; II showed almost no activity.


    Conclusion:

    This study showed little to no impact on the HPTA. This means that you will likely not experience the ‚??shutdown‚?Ě effect that is common to anabolics. This may make it easier to keep your gains in size and strength when your cycle is over.

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    Clin Gastroenterol Hepatol. 2008 Feb;6(2):255-8. Epub 2008 Jan 9.

    Methasteron-associated cholestatic liver injury: clinicopathologic findings in 5 cases.


    Shah NL, Zacharias I, Khettry U, Afdhal N, Gordon FD.

    Source

    Department of Gastroenterology, Lahey Clinic Medical Center, Burlington, Massachusetts 01805, USA.

    Abstract

    BACKGROUND & AIMS:

    Methasteron is a nutritional supplement used to increase weight or accelerate the build-up of muscle mass. The aim of this study was to describe 5 cases of hepatotoxicity in patients using methasteron seen at tertiary-care medical centers.

    METHODS:

    A case report design was used.

    RESULTS:

    Five previously healthy patients who used methasteron developed jaundice 2 weeks after discontinuation; they presented to a tertiary-care medical center 2 weeks later. Within another 2 to 3 weeks, bilirubin levels peaked. About 12 weeks after initial presentation, all cases resolved with no identifiable residual hepatic dysfunction.

    CONCLUSIONS:

    Methasteron use can result in severe hepatotoxicity. Liver failure can worsen after initial presentation, especially within 2 weeks. With close observation and supportive care, acute hepatic injury should resolve.

    PMID:18187367 [PubMed - indexed for MEDLINE]

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