Pcushion
Registered
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- Jul 26, 2019
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I have been running a hormone profile thread under the sources thread for the company I rep for. It hasn?t had the activity I would like to I am posting it here to see how it goes.
This Pro hormone brought Mark McGuire a head headache.
ANDROSTENEDIONE
(none) 4-androsten-3, 17-dione
o
Formula: Cl9Hz60z MW: 286
Androstenedione, known popularly as Andro, was the first "prohormone" to be put on the market. It
has little androgen receptor binding affinity and undergoes conversion to testosterone via 17BHSD.
Androstenedione is normally produced by the testes and adrenals at a rate of about 3.2 mg/day and
circulates at a concentration of about 5.4 nmol/L ? Of this, only about 7.5% circulates in a free,
unbound state with 6.6% bound to SH BG and 85% bound to albumin. Only about 7% of the androstenedione produced in the body is converted to testosterone while 1.7% is converted to
estrone ? Estrone is a weaker estrogen than estradiol, but can be directly converted to estradiol as
well. Soon after it was put onto the market, people began to realize that androstenedione was not very anabolic and tended to produce unwanted side effects (such as gynecomastia) quite easily most likely due to its high affinity for albumin and the fact that high doses were necessary to see any anabolic effect. Androstenedione is known to be a fairly potent aromatase inhibitor but either because it was metabolized quickly or some other reason; it still produced significant estrogenic side effects. Andro could be metabolized to more potent androgenic 5-alpha reduced metabolites and as such, could produce side effects such as acne, hair loss, prostate enlargement and others. Andro was targeted by the media after Mark Macguire admitted to using it during the time when he broke the home-run record. Andro was removed from the market as a consequence of this attention but other products were quickly produced to fill the vacuum. It has been theorized that one could use androstenedione with testosterone to interfere with 17-beta hydroxysteroid dehydrogenase to to decrease the metabolism oftestosterone.ANABOLIC PHARMACOLOGY
This Pro hormone brought Mark McGuire a head headache.
ANDROSTENEDIONE
(none) 4-androsten-3, 17-dione
o
Formula: Cl9Hz60z MW: 286
Androstenedione, known popularly as Andro, was the first "prohormone" to be put on the market. It
has little androgen receptor binding affinity and undergoes conversion to testosterone via 17BHSD.
Androstenedione is normally produced by the testes and adrenals at a rate of about 3.2 mg/day and
circulates at a concentration of about 5.4 nmol/L ? Of this, only about 7.5% circulates in a free,
unbound state with 6.6% bound to SH BG and 85% bound to albumin. Only about 7% of the androstenedione produced in the body is converted to testosterone while 1.7% is converted to
estrone ? Estrone is a weaker estrogen than estradiol, but can be directly converted to estradiol as
well. Soon after it was put onto the market, people began to realize that androstenedione was not very anabolic and tended to produce unwanted side effects (such as gynecomastia) quite easily most likely due to its high affinity for albumin and the fact that high doses were necessary to see any anabolic effect. Androstenedione is known to be a fairly potent aromatase inhibitor but either because it was metabolized quickly or some other reason; it still produced significant estrogenic side effects. Andro could be metabolized to more potent androgenic 5-alpha reduced metabolites and as such, could produce side effects such as acne, hair loss, prostate enlargement and others. Andro was targeted by the media after Mark Macguire admitted to using it during the time when he broke the home-run record. Andro was removed from the market as a consequence of this attention but other products were quickly produced to fill the vacuum. It has been theorized that one could use androstenedione with testosterone to interfere with 17-beta hydroxysteroid dehydrogenase to to decrease the metabolism oftestosterone.ANABOLIC PHARMACOLOGY