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Etizolam[SUP][1][/SUP] (marketed under the brand name Etilaam, Etizola, Sedekopan, Pasaden or Depas) is a thienodiazepine drug which is a benzodiazepine analog. The etizolam molecule differs from a benzodiazepine in that the benzene ring has been replaced by a thiophene ring.[SUP][2][/SUP] It possesses amnesic, anxiolytic, anticonvulsant, hypnotic, sedative and skeletal muscle relaxant properties.[SUP][3][/SUP]
Etizolam a thienodiazepine derivative, is absorbed fairly rapidly with peak plasma levels achieved between 30 minutes and 2 hours and has a mean elimination half life of about 3 and a half hours. However, its pharmacologically active metabolitealpha-hydroxyetizolam which has the same potency as etizolam is eliminated more slowly with a mean half life of just over 8 hours. So it can be classified as a short-medium action benzodiazepine.[SUP][11][/SUP] Etizolam possesses potent hypnoticproperties.[SUP][12][/SUP] Etizolam acts as a full agonist at the benzodiazepine receptor to produce its range of therapeutic as well as adverse effects.[SUP][13][/SUP] Similar to other benzodiazepines etizolam binds unselectively to benzodiazepine receptor subtypes.[SUP][14]
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In addition etizolam unlike most other benzodiazepines (some of which can increase levels of estradiol) has prolactogenic effects leading to an increase in prolactin blood levels.[SUP][15]
[/SUP]
According to the Italian P.I. sheet etizolam belongs to a new class of diazepines, thienotriazolodiazepines. This new class is easily oxidized, rapidly metabolized, and has a lower risk of accumulation, even after prolonged treatment. Etizolam has an anxiolytic action about 6 times greater than that of diazepam. Etizolam produces, especially at higher dosages, a reduction in time taken to fall asleep, an increase in total sleep time and a reduction in the number of awakenings. During tests there were not substantial changes in deep sleep. There is a reduction of REM sleep. In EEG tests of healthy volunteers Etizolam showed some characteristics of tricyclic antidepressants.[SUP][5]
[/SUP]Dosage
[SUP]Its also easier to get than xanax or valium. [/SUP]
Etizolam a thienodiazepine derivative, is absorbed fairly rapidly with peak plasma levels achieved between 30 minutes and 2 hours and has a mean elimination half life of about 3 and a half hours. However, its pharmacologically active metabolitealpha-hydroxyetizolam which has the same potency as etizolam is eliminated more slowly with a mean half life of just over 8 hours. So it can be classified as a short-medium action benzodiazepine.[SUP][11][/SUP] Etizolam possesses potent hypnoticproperties.[SUP][12][/SUP] Etizolam acts as a full agonist at the benzodiazepine receptor to produce its range of therapeutic as well as adverse effects.[SUP][13][/SUP] Similar to other benzodiazepines etizolam binds unselectively to benzodiazepine receptor subtypes.[SUP][14]
[/SUP]
In addition etizolam unlike most other benzodiazepines (some of which can increase levels of estradiol) has prolactogenic effects leading to an increase in prolactin blood levels.[SUP][15]
[/SUP]
According to the Italian P.I. sheet etizolam belongs to a new class of diazepines, thienotriazolodiazepines. This new class is easily oxidized, rapidly metabolized, and has a lower risk of accumulation, even after prolonged treatment. Etizolam has an anxiolytic action about 6 times greater than that of diazepam. Etizolam produces, especially at higher dosages, a reduction in time taken to fall asleep, an increase in total sleep time and a reduction in the number of awakenings. During tests there were not substantial changes in deep sleep. There is a reduction of REM sleep. In EEG tests of healthy volunteers Etizolam showed some characteristics of tricyclic antidepressants.[SUP][5]
[/SUP]Dosage
- For anxiety: 0.50-1 mg two or three times per day (maximum 2 mg per day)
- For insomnia: 1-2 mg before bedtime
[SUP]Its also easier to get than xanax or valium. [/SUP]
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