Effective Dose: Most people need to be careful to start with a low dosage, about 25 mcgs. per day and increase by about one tab or 25 mcgs. per day every 5-6 days. Make sure that you don't go over 100 mcgs. per day at the very most. On days that you take multiple tabs, divide the tabs evenly across the day (i.e. 100 mcgs. would be 4 doses of 25 mcgs. apiece spread evenly across the day.) You also need to make sure that you cycle down off this product as well to keep the thyroid functioning properly as well. Don't take for more than 5 weeks at a time as well. After doing a cycle of this drug, make sure you go at least 8 weeks before doing it again as to allow normal thyroid functioning to return.