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Research Stop letrozole

Muscle Gelz Transdermals
IronMag Labs Prohormones
well this is disappointing. i've always thought researchstop was pretty much the only 100% trustable research chem site that we can all go to when we get bunk chems from other sites. it's the only site i've heard absolutely no negative reports about until now.

looks like no research company's are 100% trustworthy now....
 
It may be a personal thing that I don't respond to the liquid versions? Idk I'm on tabs now well see in a few weeks.
 
heavyiron said:
I would estimate you are at maximum aromatization potential with your doses/compounds. Letro can lower E2 about 50% in males, maybe a bit less in young males. E2 can easily be in the 200-300's with your compounds/doses but this can be individualistic. Go off the Letro and see if your E2 raises significantly and you will know if its bunk or not.
Click to expand...

Is there any conclusive research on this? I have seen some knowledgeable people say that E2 can only be lowered by AIs by about 50% in males, which maybe explains why on 500mg of Test E my E2 was 58 on 0.5mg of ManPowers Adex EOD but only down to 53 on 2.5mg of his letro ED?

But then I see other posts like....
Buckeye Fan said:
I honestly think the liquid degrades the potency. I know plenty of guys taking 1mg arimidex tabs on 1500mg of test with estro at 10.
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johnthejello said:
well this is disappointing. i've always thought researchstop was pretty much the only 100% trustable research chem site that we can all go to when we get bunk chems from other sites. it's the only site i've heard absolutely no negative reports about until now.

looks like no research company's are 100% trustworthy now....
Click to expand...

Definitely disappointing. They were the only company I had yet to see anything bad about. ChemOne I hear good things about but have seen 1 bad review. I hear ResearchStops aromasin is good and a friend of mine had pretty low E while taking it so who knows, maybe the letro was a bad batch or was losing potency. Sucks that we can't really know for sure with these things
 
Yeah it's hard to tell whether it was bad or if I just got the most of it at the beginning bc it was mixed well. I'm sticking with tabs from here on out.
 
Buckeye Fan said:
Yeah it's hard to tell whether it was bad or if I just got the most of it at the beginning bc it was mixed well. I'm sticking with tabs from here on out.
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Where'd you get your tabs from? and how do they seem to be working so far?
 
Pumped340 said:
Is there any conclusive research on this? I have seen some knowledgeable people say that E2 can only be lowered by AIs by about 50% in males, which maybe explains why on 500mg of Test E my E2 was 58 on 0.5mg of ManPowers Adex EOD but only down to 53 on 2.5mg of his letro ED.
Click to expand...

Yes, we have various studies that demonstrate this E2 reduction in males. The OP did not follow any proven protocol so the info provided is basically useless. If he had used the Letro without steroids and had before and after labs we would have decent evidence. Unfortunately this section has become a huge bro-science section where guys are running all kinds of untested and irrelevent tests.
 
heavyiron said:
Yes, we have various studies that demonstrate this E2 reduction in males. The OP did not follow any proven protocol so the info provided is basically useless. If he had used the Letro without steroids and had before and after labs we would have decent evidence. Unfortunately this section has become a huge bro-science section where guys are running all kinds of untested and irrelevent tests.
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I agree that it's harder to come to conclusions without true scientific testing, but the OP has shown that his E2 levels were 100+, so now that they're ~14 while on 1000mg Test how do you explain that if studies demonstrate only 50-60% max reduction from AIs?
 
Pumped340 said:
I agree that it's harder to come to conclusions without true scientific testing, but the OP has shown that his E2 levels were 100+, so now that they're ~14 while on 1000mg Test how do you explain that if studies demonstrate only 50-60% max reduction from AIs?
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The AI studies were done in males NOT using steroids. These were controlled studies with properly dosed AI's. This is my point. If a guy runs an AI without steroids and gets before and during labs it will prove the AI.

J Clin Endocrinol Metab. 2005 Oct;90(10):5717-22. Epub 2005 Jul 26.

Comparative assessment in young and elderly men of the gonadotropin response to aromatase inhibition.

T'Sjoen GG, Giagulli VA, Delva H, Crabbe P, De Bacquer D, Kaufman JM.
Department of Endocrinology, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium. guy.tsjoen@ugent.be

Abstract

CONTEXT: Aging in men is associated with a decline in serum testosterone (T) levels.
OBJECTIVE: Our objective was to assess whether decreased T in aging might result from increased estradiol (E2) negative feedback on gonadotropin secretion.
DESIGN AND SETTING: We conducted a comparative intervention study (2004) in the Outpatient Endocrinology Clinic, Ghent University Hospital.
PARTICIPANTS: Participants included healthy young and elderly men (n = 10 vs. 10).
INTERVENTIONS: We used placebo and letrozole (2.5 mg/d) for 28 d, separated by 2 wk washout.
MAIN OUTCOME MEASURES: We assessed changes in serum levels of free E2, LH, and FSH, free T, SHBG, and gonadotropins response to an i.v. 2.5-microg GnRH bolus.
RESULTS: As assessed after 28 d of treatment, letrozole lowered E2 by 46% in the young men (P = 0.002) and 62% in the elderly men (P < 0.001). In both age groups, letrozole, but not placebo, significantly increased LH levels (339 and 323% in the young and the elderly, respectively) and T (146 and 99%, respectively) (P value of young vs. elderly was not significant). Under letrozole, peak LH response to GnRH was 152 and 52% increase from baseline in young and older men, respectively (P = 0.01).
CONCLUSIONS: Aromatase inhibition markedly increased basal LH and T levels and the LH response to GnRH in both young and elderly men. The observation of similar to greater LH responses in the young compared with the elderly does not support the hypothesis that increased restraining of LH secretion by endogenous estrogens is instrumental in age-related decline of Leydig cell function.


PMID: 16046582 [PubMed - indexed for MEDLINE]
 
heavyiron said:
The AI studies were done in males NOT using steroids. These were controlled studies with properly dosed AI's. This is my point. If a guy runs an AI without steroids and gets before and during labs it will prove the AI.

J Clin Endocrinol Metab. 2005 Oct;90(10):5717-22. Epub 2005 Jul 26.

Comparative assessment in young and elderly men of the gonadotropin response to aromatase inhibition.

T'Sjoen GG, Giagulli VA, Delva H, Crabbe P, De Bacquer D, Kaufman JM.
Department of Endocrinology, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium. guy.tsjoen@ugent.be

Abstract

CONTEXT: Aging in men is associated with a decline in serum testosterone (T) levels.
OBJECTIVE: Our objective was to assess whether decreased T in aging might result from increased estradiol (E2) negative feedback on gonadotropin secretion.
DESIGN AND SETTING: We conducted a comparative intervention study (2004) in the Outpatient Endocrinology Clinic, Ghent University Hospital.
PARTICIPANTS: Participants included healthy young and elderly men (n = 10 vs. 10).
INTERVENTIONS: We used placebo and letrozole (2.5 mg/d) for 28 d, separated by 2 wk washout.
MAIN OUTCOME MEASURES: We assessed changes in serum levels of free E2, LH, and FSH, free T, SHBG, and gonadotropins response to an i.v. 2.5-microg GnRH bolus.
RESULTS: As assessed after 28 d of treatment, letrozole lowered E2 by 46% in the young men (P = 0.002) and 62% in the elderly men (P < 0.001). In both age groups, letrozole, but not placebo, significantly increased LH levels (339 and 323% in the young and the elderly, respectively) and T (146 and 99%, respectively) (P value of young vs. elderly was not significant). Under letrozole, peak LH response to GnRH was 152 and 52% increase from baseline in young and older men, respectively (P = 0.01).
CONCLUSIONS: Aromatase inhibition markedly increased basal LH and T levels and the LH response to GnRH in both young and elderly men. The observation of similar to greater LH responses in the young compared with the elderly does not support the hypothesis that increased restraining of LH secretion by endogenous estrogens is instrumental in age-related decline of Leydig cell function.


PMID: 16046582 [PubMed - indexed for MEDLINE]
Click to expand...

Its likely that letrozole only decreases estradiol by ~50% in normal males, but not in males taking supraphysiological levels of aromatizing steroids. for example, if a normal male has an estradiol level of ~20 pg/ml, letrozole obviously cannot lower that to 0, rather it might lower it ~50%, like you said. probably because there are areas of the body where high rates of aromatization happens, but letrozole cannot penetrate/diffuse into well or the body's homestatic response to the high androgen:estorgen ratio, thus an increase in aromatase. however, if a person is on very high levels of aromatizing steroids, their estrogen levels will obviously be high because aromatase has more substrate to catalyze into estrogens and because higher concentrations of substrate allow for a greater probability of a molecule "hitting" and binding to the enzyme, though, aromatase levels usually remain steady (though, theorized that high levels of androgen MAY slightly upregulate aromatase), so if letrozole is taken, it will still bind to the same aromatase and prevent the aromatizing steroids from being converted throughout most of the body. even with all the homeostatic variables favoring estrogen which i mentioned (which is very unlikely), estradiol should not be 163 pg/ml, even with a rise from his previous 109 pg/ml. that is just ridiculous and researchstops letro is probably EXTREMELY underdosed/fully bunk or OP is a female.
 
Last edited:
johnthejello said:
Its likely that letrozole only decreases estradiol by ~50% in normal males, but not in males taking supraphysiological levels of aromatizing steroids.
Click to expand...

Obviously, that's why the younger males (with higher T) had a lower response than the older males. =)
 
OK so AIs can only lower E2 about 50% in normal males, but more in those on a test cycle? I mean clearly the OP got a huge reduction in E2 from his AI or whatever it was.
 
Muscle Gelz Transdermals
IronMag Labs Prohormones
Not to call anyone a liar or not saying theres a possibility of a bad batch but researchstop's arimidex, clen and cialis were g2g for the past couple years. Clen makes me tremble, cialis speaks for itself and arimidex although with no labs my slight gyno(unoticeble by eye just touch) has never gotten worse in years, and I blast and cruise so I never really am "off". Now as for the rest of products or ones I just mentioned that were just purchased I can't speak of, just only from my experiences.
 
Farewell said:
Just another update researchstop was definalty crap
Got some Letro from mpresearchsupply.com (great deals, lots of possessive up to date reviews)
Im on 3rd week, pain is gone thank god and is shrinking and def feeling side.
Sore joints, feeling lethargic no drive.
Click to expand...

Interesting, thats for the update....I just ordered more AI and decided on Letro from PurchasePeptides, they seem to have gotten a lot of good reviews.

Regarding MPs Letro, I had some and on 500mg of Test E my E2 was 53 while taking 2.5mg letro per day for the prior 2 weeks, which is about the same as it was on 0.5mg of his adex every other day so I'm thinking the letro was either very underdosed or bunk, although if it was completely bunk my e2 probably would have been significantly higher. He gave me 2 more packs though which were obviously newer, hopefully those will be more properly dosed. What is the expiration date on your letro? My old one is 3/13, the new ones are 2/14
 
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